PubMed Health⌕ Search

Biomedical subjects

B Clay

Publications and source records attributed to B Clay.

10 recordsLinked to original sources

Systematics of the enigmatic kathablepharids, including EM characterization of the type species, Kathablepharis phoenikoston, and new observations on K. remigera comb.nov.

The colorless flagellate Kathablepharis has consisted of five species based on light microscopic studies, and the ultrastructure of the type species, Kathablepharis phoenikoston, is described for the first time. The heterotrophic, marine flagellate Leucocryptos consisted of two species, but additional ultrastructural details for one of these, Kathablepharis remigera comb. nov. (= Leucocryptos remigera Vørs), indicates that it should be transferred to Kathablepharis. The cellular structure of these two species is similar to previously studied kathablepharids. However, there is variation in the feeding apparatus and cytoskeleton. The feeding apparatus of both species has a cytostome, a cytostomal ring, and cytopharyngeal rings. The cytoskeleton consists of inner microtubular arrays and outer or sub-pellicular microtubular arrays. In addition, several features of the flagellar apparatus are described for K. phoenikoston and K. remigera. The ultrastructure of these two species is compared with other kathablepharids to evaluate their taxonomy and phylogeny. We classify Kathablepharis and Leucocryptos in the family Kathablepharididae incertae sedis.

Animals↗

Medical workforce and the gender shift.

The future medical staffing for the NHS needs to take account of the demands of doctors for a humane lifestyle and the service demands of all groups of patients. The increasing numbers of female practitioners and the reduction in hours required by new legislation will be important influences. Suggestions are made about possible future working patterns.

Ethnicity↗

Nonradiographic assessment of enteral feeding tube position.

OBJECTIVE: To determine whether a clinical, nonradiographic criterion can be used to predict when the tip of a blindly placed feeding tube is in the small intestine. DESIGN: Prospective sample. SETTING: Pediatric intensive care unit at a tertiary care children's hospital. PATIENTS: Critically ill children requiring transpyloric feeding. INTERVENTIONS: The small bowel was intubated, using a blind, bedside transpyloric feeding tube placement protocol. The feeding tube was considered to be in the small bowel when <2 mL of a 10- mL aliquot of insufflated air could be aspirated from the feeding tube. This clinical criterion was confirmed with an abdominal radiograph. MEASUREMENTS AND MAIN RESULTS: Patient age ranged from 1 month to 19 yrs (median 6 months). Weight ranged from 2.2 to 60 kg (median 4.9). Median time to feeding tube placement was 10 mins (range 5 to 60). Eighty-nine percent of the patients were mechanically ventilated, while 28% of these patients were pharmacologically paralyzed. Seventy-five feeding tubes were inserted. There were no known complications. Ninety-nine (74/75) percent of the feeding tubes were positioned in the small bowel. The inability to aspirate insufflated air correctly predicted small bowel intubation with 99% certainty (Sequential Probability Ratio Test, p = .05 and power = .80). This test incorrectly predicted the position of only one feeding tube, the 26th, which was in the stomach. Of the 74 feeding tubes positioned in the small bowel, 13 feeding tubes were in the duodenum and 61 were in the jejunum. CONCLUSIONS: The inability to aspirate insufflated air confirms the transpyloric position of a feeding tube. Other clinical criteria did not successfully predict small bowel intubation. Use of this single test may obviate confirmatory abdominal radiographs in carefully selected patients and may lead to more cost-effective and timely initiation of enteral feedings.

Adolescent↗

Pharmacokinetics of severe theophylline intoxication managed by peritoneal dialysis.

In a patient severely poisoned with theophylline, saturation kinetics were demonstrated at serum concentrations > 35 micrograms/ml with subsequent conversion to first order kinetics (t 1/2 = 5.4 h). Peritoneal dialysis was used to enhance the drug's removal. The mean theophylline clearance was greater for dialysate (5.11 ml/min) than for urine (1.98 ml/min) or gastric fluid (0.32 ml/min). Urinary elimination occurred as a constant first order process (t 1/2 = 4.3 h). Peritoneal dialysis is a valuable early adjunct in the management of severe theophylline intoxication.

Child, Preschool↗

Response to lactating dairy cows to abomasal infusion of amino acids.

Essential amino acids most limiting for milk production and/or secretion of milk protein were determined in five trials involving infusion of amino acids into the abomasum of lactating Holstein cows. Cows were fed corn-based rations containing 10.7 to 11.5% crude protein (dry matter basis) which exceeded standard allowances for energy. All trials were Latin-square designs with 9-day periods. The abomasal infusion of methionine had no effect on secretion of milk, milk protein, or milk fat. Lysine infusion resulted in 16% of the total response in yield of milk protein that was obtained with either the 10 essential amino acids or sodium caseinate while infusion of lysine and methionine together accounted for 43% of the total response. This suggested that lysine and methionine were first and second limiting, or co-limiting, for secretion of milk protein when rations consisting primarily of corn, corn silage, and alfalfa-grass hay were fed. The primary effect was on content of milk protein rather than milk yield. In general, amino acid infusions had no effect on feed intake, milk fat, and nonprotein nitrogen content of milk. Little change occurred in concentrations in plasma of other amino acids when lysine and methionine were infused together. When concentrations were lowered, indicating increased protein synthesis, changes were too small to be statistically significant.

Abomasum↗

Indium (111In)-labelled bleomycin for the detection of intracranial lesions.

Brain scans with 99mTc pertechnetate were compared with scans made after administration of 111Indium bleomycin in 38 patients scanned on 41 occasions. They gave similar results in 34 pairs of examinations, including cases in which both failed to detect the tumour. In seven cases, the two agents differed. In two of these bleomycin distinguished residual tumour from the effects of craniotomy more clearly than did pertechnetate; in three bleomycin apparently detected tumour not seen with pertechnetate, and in two the differences may have been due to technical factors, or are unexplained.

Adult↗

Procidentia and ureteric obstruction.

3 cases of renal failure, due to procidentia, presenting as emergencies are described. The upper urinary tracts of 4 asymptomatic patients with procidentia were investigated; dilatation was found in 1 instance only.

Acute Kidney Injury↗