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Biomedical subjects

B Colombo

Publications and source records attributed to B Colombo.

At least 73 records · Page 4Linked to original sources
PubMed1982

Indoprofen in rheumatic patients with acute episodes: a multicentre trial.

The results are reported of an open multicentre trial in 228 rheumatic patients with flare-ups. Fourteen centres adopting the same investigational protocol collaborated in the study. Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i.v. bolus was followed by 200 mg (1 tablet) t.i.d. Subjective (pain) and objective variables were used for reliable assessment of activity. Marked reduction of pain intensity was already noticeable on day 1 of treatment and was followed by progressive improvement in subjective and objective variables for all the diagnoses considered. According to the patients' own overall assessments, results were good or very good in more than 50% of cases. The best outcomes were obtained in low back pain, acute gout and psoriatic arthritis. At the end of treatment only 7.4% of patients experienced no change or deterioration of symptoms. Adverse reactions, consisting mostly of mild and reversible gastrointestinal disturbances, were reported by 9.2% of patients, but only in 1.8% was treatment discontinued. Indoprofen administered according to the above schedule is an appropriate treatment for acute episodes of rheumatic diseases.

Adolescent↗
PubMed1981

The switch from haemoglobin F to A: the time course of qualitative and quantitative variations of haemoglobins after birth.

The time course of the transition from HbF to HbA production in the postnatal period has been studied. The description is based on the time-dependent pattern of total haemoglobin and of HbF observed in an 8 months follow-up of 25 premature newborns. The absolute amount of HbF decreases exponentially from birth to approximately 25 weeks (from 15.56 +/- 0.48 g/dl to 0.66 +/- 0.08 g/dl), at a weekly rate of approximately 16%. On the other hand, HbA shows a biphasic pattern: first it decreases slightly from birth to 6 weeks (from 4.09 +/- 0.32 g/dl to 2. 63 +/- 0.33 g/dl); afterwards it increases exponentially at a weekly rate of 5% up to a plateau value, until HbF is almost completely replaced by HbA. Therefore the total haemoglobin decreases exponentially from birth to approximately constant for the next 6 weeks, and thereafter it increases very slowly. From these data, two distinct phases of postnatal erythropoiesis can be identified: the first (from birth to 6 weeks) is characterized by a decrease in the total amount of haemoglobin produced whereas in the second there is an alteration in the relative proportions of HbF and HbA being synthesized.

Analysis of Variance↗
PubMed1981

Effects of creatine administration on experimental liver fibrosis and on creatine and phosphocreatine content of rat muscle.

Creatine administration has no effect on the induction of liver cirrhosis caused by CCl4 in the rat. The muscle creatine content decreases in rats given CCl4 and this change is not modified by creatine treatment. Administered on its own it depresses the level of muscle creatine in normal rats. Creatinine administration increases the uptake of radioactive creatine by the muscle.

Animals↗
PubMed1979

[The evolution of cardiac impairment in Duchenne's muscular dystrophy. Electrovector-cardiographic, polycardiographic and echocardiographic aspects (author's transl)].

The Authors have submitted to an electrocardiographic, vectorcardiographic, mechanocardiographic and echocardiographic investigation 4 cases with Duchenne's disease, which had already been studied by the Authors several years before. The longitudinal study has demonstrated, above all, the striking capacity of the electrocardiographic aspects of the disease to evolve from a normal to a "pseudo-necrotic" pattern. Such evolution, among other things, provides an important argument against the interpretation that attributes the electrocardiographic and vectorcardiographic changes in the initial stages of the disease to a persistence of a QRS loop of infantile type on a genetic basis. But for rare exceptions, the systolic time intervals and kinetocardiogram, which showed early indicative changes on the first examination, have successively shown easily predictable behavior considering the poor cardiovascular conditions of the patients on the second examination. The echocardiogram has proved useful in demonstrating the morphological and functional changes of the ventricular walls and of the interventricular septum, besides the eventual associated mitral valve prolapse. The echocardiographic evaluation of the left ventricular performance in quantitative terms, however, seems somewhat unreliable owing to the difficulty of obtaining technically good images, due to the thoracic deformity. The dystrophic changes recently observed in the myocardium even at ultrastructural level can probably explain not only the electrocardiographic and vectorcardiographic abnormalities but also the kinetocardiographic and echocardiographic changes. Among the above mentioned theoretical and practical considerations the possibility should be underlined that some cases of cardiomyopathy labelled as "primary" are in fact unrecognized dystrophic cardiomyopathies.

Adolescent↗
PubMed1979

On some cardiological aspects of Steinert's disease (myotonic dystrophy).

The authors investigated 10 ambulant patients with myotonic dystrophy, under 40 years of age (mean 22.3 years) and free of subjective heart complaints. Not only Ecg alterations but also kinetocardiographic changes and anomalies of the systolic intervals were rarer and milder than those found in patients with other neuromyopathies, namely Friedreich's disease and Duchenne's disease. This observation suggests that, at least in older patients, not all the cardiac alterations usually attributed to myotonic dystrophy are really imputable to the disease. On the other hand, the observed echocardiographic alterations (reduction of per cent systolic-diastolic variation of internal diameter of the left ventricle and/or the ejection fraction) apparently indicate an early tendency to modification of left ventricular function in patients with myotonic dystrophy. Since other authors have found cardiac anomalies in this disease before the onset of any neurological manifestations, the possibility emerges that some cases of myocardial disease interpreted as "primitive" might in reality be secondary to undetected myopathy.

Adolescent↗
PubMed1978

Heterogeneity of hereditary methaemoglobinaemia: a study of 4 Cuban families with NADH-Methaemoglobin reductase deficiency including a new variant (Santiago de Cuba variant).

NADH-methaemoglobin reductase deficiency has been found in 4 Cuban families; 3 subjects carried the mild form of the deficiency while in 2 sibs of the fourth family the deficiency was associated with neurological involvement. The parents in this family were consanguinous and the sibs were shown to be homozygous for a new fast electrophoretic variant. It was named Diaphorase Santiago de Cuba.

Adolescent↗
PubMed1978

Hb J Camaguey alpha 2 141(HC3) Arg replaced by Gly beta 2: a new abnormal human hemoglobin.

An electrophoretic fast-moving hemoglobin was found in a Cuban family of Spanish descent. Structural studies demonstrated a replacement of arginine by glycine at alpha 141(HC3). This change is not associated with clinical symptoms, although the substitution is in one of the residues involved in the stabilization of the deoxy form of the hemoglobin molecule.

Amino Acids↗
PubMed1977

Haemoglobin J Guantanamo (alpha 2 beta 2 128 (H6) Ala replaced by Asp). A new fast unstable haemoglobin found in a Cuban family.

Haemoglobin J Guantanamo (alpha 2 beta 2 128 (H6) Ala replaced by Asp) was found during a screening from abnormal haemoglobins in three members of a Cuban family, of negro ancestry. The substitution in this variant is located at the alpha 1 beta 1 contact. This explains the slight instability and the mild haemolytic anaemia and morphological abnormalities found in the carriers of this variant. The instability of haemoglobin J Guantanamo indicates that the presence of Asp at the position beta-128 (H6) weakens the alpha 1 beta 1 contact.

Alanine↗
PubMed1977

Haemoglobin Porto Alegre in a Cuban family.

During a screening programme for abnormal haemoglobins in Habana, one case of Hb Porto Alegre was found in 23 000 cases analysed. The ability of this variant to polymerise in vitro and the absence of clinical features in the carriers have been confirmed. These observations are now explained by the findings of high levels of glutathione in the red cells of subjects heterozygous for Hb Porto Alegre: it is suggested that the increase of glutathione is responsible for the absence of in vivo polymerisation and accounts for the lack of clinical symptoms.

Adolescent↗