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Biomedical subjects

B Cornelius

Publications and source records attributed to B Cornelius.

2 recordsLinked to original sources

[Cardiogenic shock after adrenalectomy for pheochromocytoma].

A 56 year old patient underwent left-sided adrenalectomy for a benign pheochromocytoma. During surgery, he developed a hypertensive crisis while the tumor was being manipulated. Postoperatively, the patient became hypotensive and developed cardiogenic shock. He remained ventilated and intubated. In the subsequent echocardiography a severely impaired left ventricular function with apical akinesia was observed, while the preoperative echocardiogram was normal. Acute coronary angiography was performed which showed no significant stenoses in the coronary arteries. Apical ballooning was seen in the left ventricular angiogram. On the second postoperative day, echocardiography showed an improved left ventricular function which was almost normalized within the next week. Catecholamine release during a left-sided adrenalectomy for a benign pheochromocytoma was associated with Takotsubo cardiomyopathy complicated by cardiogenic shock.

Adrenal Gland Neoplasms↗

Amphetamine enhances training-induced motor cortex plasticity.

OBJECTIVES: Repetitive synchronized movements lead to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS). Drugs which enhance such plastic changes could be of therapeutical interest, e.g. in patients with cerebral lesions. MATERIAL AND METHODS: We studied the effect of amphetamine on motor performance and plastic changes in the motor cortex as revealed by TMS mapping in healthy humans, who had to train a repetitive synchronized movement over 1 h. RESULTS: Cortical plastic changes observed after 1 h of training were more pronounced with amphetamine, whereas motor performance did not differ between training sessions with and without amphetamine. CONCLUSION: We conclude that amphetamine is able to enhance training-induced motor cortex plasticity. This effect could be due to its known influence on the GABAergic and glutamatergic system, but might also result from its role as an indirect catecholaminergic agonist.

Adult↗