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Biomedical subjects

B Covelli

Publications and source records attributed to B Covelli.

12 recordsLinked to original sources
PubMed1989

[Monotherapy, empirical and targetted, with imipenem-cilastatin in sepsis of bacterial origin].

The authors describe an open study in 22 patients with febrile conditions of unknown origin who were treated with imipenem-cilastatin while waiting for routine laboratory and culture tests. These were done immediately at the patients' entry into hospital, after which imipenem-cilastatin treatment was started immediately, and was subsequently confirmed by the isolates and culture tests. The drug was found to be active and to eradicate the responsible organism in all cases. In addition, it was found to be easy to handle and not to give rise to side-effects or changes in laboratory tests.

Adolescent↗
PubMed1989

Evaluation of ciprofloxacin's activity against recent clinical isolates.

The in vitro antibacterial activity of ciprofloxacin, a new quinoline carboxylic acid, was tested against 1671 recently clinically isolated bacterial strains, by measuring the minimum inhibitory concentrations (MIC). Comparisons were made with other quinolones: nalidixic acid, norfloxacin, and other drugs: piperacillin, cefoxitin, cefotetan, ceftazidime, tobramycin, rifampin, tetracycline, chloramphenicol. Ciprofloxacin was very active against the tested species and was the most active drug against all the bacterial strains, with a geometric mean, a MIC50 and MIC90 of 0.27, 0.12 and 2 micrograms/ml, respectively.

Bacteria↗
PubMed1988

Evaluation of in vitro activity of teicoplanin against recent clinical isolates.

The in vitro antibacterial activity of teicoplanin, a new glycopeptide antibiotic, previously named teichomycin A2, has been compared to that of five other chemoantibiotics: netilmicin, clindamycin, rifampicin, enoxacin and vancomycin. The minimum inhibitory concentration (MIC) values against 588 gram-positive strains, 561 facultative aerobes and 27 anaerobes, recently isolated from clinical specimens, were evaluated. Teicoplanin showed the highest activity against all the tested strains, with a geometrical mean of the MICs (GMM), a MIC50 and MIC90 of 0.123, 0.12 and 0.5 micrograms/ml respectively.

Anti-Bacterial Agents↗
PubMed1977

[Biomechanics of vertebral segments. Clinical and prognostical interpretations (author's transl)].

The authors propose a new model to estimate the forces of the intrinsic equilibrium of the segment. Based on the theory of the so-called transient pole, it became possible to describe the momentary movement of an angle relative to its neighbour and to define the way of the intrinsic equilibrium. This transient pole fixes the centre of rotation around which the upper angle moves relative to the lower vertebral body. Normal and pathological cases can be diagnosed at once by use of a special röntgenological appliance in connection with the statistical experience. It becomes possible to calculate the forces and movements acting on a segment.

Biomechanical Phenomena↗
PubMed1976

[Contribution toward determining the inner equilibrium of the spinal column (pivotal point as temporary pole) (author's transl)].

The estimation of the centre of rotation of a spine segment can be shown as a transient pole, which follows the polar curve of the movement of the upper segment of the spine, relative to the lower one. With the help of X-ray, it is possible to evaluate two separate positions of the pole, from the normal position to the medium flexion and from the medium to the extreme flexion of the lumbal segment. Based on these expected values, as well as their intervals, pathological cases can be recognized, which is also shown in an example.

Biomechanical Phenomena↗
PubMed1976

[Can the human posture be explained by biomechanics? (author's transl)].

Up to now, lacking a bio-mechanical model, human posture has only been examined morphologically, although the physics of posture respond to simple laws. With the help of a physical model, based on the hypothesis of a minimal rotating movement of the trunk and head from the spine, this report gives a description of a normal posture. The model can be extended mathematically to establish a computer simulation of each case examined by X-ray, showing which posture would use the smallest amount of ligamentary and muscular force. The above bio-mechanical analyses of the spine as a whole is being further examined and improved mathematically.

Biomechanical Phenomena↗
PubMedDate not supplied

[Bactericidal and potent antiadhesive activity of sulbenicillin].

Sulbenicillin, a wide broad spectrum penicillin, is active against a lot of gram positive and gram negative bacteria. The AA. studied the activity of this molecule against urinary infections causing germs, by evaluating two parameters: his antiadhesive capability and the Killing curves, in comparison with mezlocillin and piperacillin. An inhibition in adhesive capability of test-germs, due to sulbenicillin was obtained. Furthermore, resulting Killing curves showed more rapidity in action for sulbenicillin than for the two others molecules, versus resistant germs, like P. aeruginosa and S. faecalis.

Bacterial Adhesion↗