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Biomedical subjects

B Cribier

Publications and source records attributed to B Cribier.

10 recordsLinked to original sources
PubMed1992

Staphylococcus aureus leukocidin: a new virulence factor in cutaneous infections? An epidemiological and experimental study.

Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus (SA) exotoxin, which kills human granulocytes and monocytes in vitro. Among 43 SA strains from cutaneous infections, 12 were PVL producers, whereas among 49 blood culture strains, only 1 produced PVL. Most PVL-producing strains (11/22) came from 22 primitive cutaneous infections, especially furuncles and abscesses, while only 1 PVL-producing strain came from 21 secondary infections of dermatoses such as bullous or pruritic diseases. Intradermal injections of PVL in rabbits induced edema, erythema and necrosis; histopathological changes at the injection sites consisted mainly in leukocytoclasis and vascular necrosis. All changes were dose dependent, and previous immunization of rabbits partially neutralized PVL-induced effects. Production of PVL in vivo after injections of bacteria seems to be low, and the histopathological lesions induced in the rabbit skin do not appear to be specifically related to PVL activity. However, PVL is a good candidate as a new virulence factor in cutaneous SA infections.

Animals↗
PubMed1992

Renal impairment probably induced by etretinate.

A 83-year-old patient had been treated for pityriasis rubra pilaris with 70 mg etretinate daily. He developed acute renal impairment, with creatinine levels reaching 73 mg/l on day 7. After discontinuation of etretinate, all biological changes were reversible. Although renal impairment is not considered as retinoid side effect, the chronology of renal changes is very suggestive of etretinate responsibility.

Acute Kidney Injury↗
PubMed1992

[Immunohistochemistry of nodular vasculitis. A possible role of delayed cellular hypersensitivity].

The physiopathogenesis of nodular vasculitis is still unknown: there is probably an initial Arthus' phenomenon responsible for the lesions of the deep vessels, but the frequent recurrences and the long time duration of the hypodermic nodules are still not understood. Dendritic protein S100 positive cells had previously been observed within hypodermal granulomas. The purpose of this study was to confirm these observations in a large group of nodular vasculitis, and to compare the expression of S100 protein in other vascular diseases and in pure panniculitis. Immunohistochemical staining for S100 protein was performed on paraffine-embedded samples: 45 cases of nodular vasculitis, 21 of panniculitis, 10 of superficial leucocytoclastic vasculitis, 10 of periarteritis nodosa, and 10 of erythema nodosum were analyzed by means of optic microscopy. Numerous dendritic S100 protein positive cells were found within hypodermal granulomas in most of the cases of nodular vasculitis, but these cells were absent in the 3 cases of initial deep leucocytoclastic vasculitis lesions of nodular vasculitis. The mean percentage of these cells was 4.5 p. 100 in the hypodermal inflammatory areas; they were observed mainly around vascular lesions. Hypodermal dendritic cells were absent or less numerous in all other cases, and a high number of such cells seems to be observed only in nodular vasculitis. Because of their dendritic morphology, and the high expression of S100 protein, these cells could be interdigitated cells, which are known to present antigens to T-lymphocytes. They could play an important role in generating the chronicity of nodular vasculitis, by a mechanism of delayed cell-mediated hypersensitivity, after the initial lesions caused by immune complexes.

Dendritic Cells↗
PubMed1991

[Multiple infundibuloma].

A 42-year-old man presented with multiple hypopigmented macules, 4 to 10 mm wide, irregularly shaped and symmetrically distributed on the neck and face, with a 10 years duration. Histological examinations showed a plate-like epithelial proliferation below the epidermis. The cells had a pale cytoplasm, with few PAS positive granules. In the lower part of the proliferation the peripheral cells were palisading and surrounded by a dense elastic network. Serial sections showed connections with the normal outer root sheath of the neighbour follicles, and with the epidermis. This pattern is very characteristic of Mehregan's tumor of follicular infundibulum. Four distinctive presentations of this tumor can be observed, in spite of its rarity: multiple macules of the upper chest or face (4 cases have previously been described), tumors of follicular infundibulum occurring in Cowden's disease or in the natural course of organoid nevi, and the most common solitary form of the face. With their striking clinical features, the eruptive or multiple forms of this tumor should be recognized as a distinctive clinical entity. Possible transformation into basal cell carcinoma has been described in one of these cases, and long time supervision should be recommended.

Adult↗
PubMed1990

[Bazin's erythema induratum: obsolete concept and terminology].

In 1855 Ernest Bazin, who had noted hard, deep and violaceous nodules on the legs of young women, created his famous "erythema induratum" classified among the "erythematous benign scrofulides". Some forty years later, identical lesions were observed associated with tuberculosis; Colcott-Fox called them "érythème induré de Bazin", and ever since that time erythema induratum has been presumed to be of tuberculous origin. In 1900, Darier spoke of "tuberculids" for erythema induratum, and Bazin's "scrofulides" were abusively translated as "tuberculids". In the early 20th century many authors described such skin lesions without any evidence of tuberculosis and later on many papers tried to deny this "systematic" association, but the idea that erythema induratum is caused by tuberculosis still lingers on in 1990. There are many arguments against a tuberculous aetiology, but although very few cases in large series are really associated with tuberculosis many patients have been treated with specific antituberculous agents. For numerous authors, erythema induratum in "tuberculous by definition". In 1945 Montgomery et al. created the "nodular vasculitis" concept. The clinical features are very similar to those of erythema induratum but the disease is certainly not of tuberculous origin. This new pathology has been well developed by French and Spanish authors (Bureau, Duperrat, Vilanova). Despite repeated efforts to separate these two "entities" no clinical or histological data are available to distinguish between erythema induratum and nodular vasculitis. The real meaning of "erythema induratum" is far from being clear: in old publications and sometimes in recent textbooks one can find the same name followed by of Bazin, Whitfield or Hutchinson. Some authors call the disease tuberculids, and other believe it is a true cutaneous tuberculosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Diagnosis, Differential↗