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B Cueni

Publications and source records attributed to B Cueni.

13 recordsLinked to original sources
PubMed1977

[Combined form of chronic aggressive hepatitis primary biliary cirrhosis].

15 patients with primary biliary cirrhosis (PBC) and 109 patients with chronic aggressive hepatitis (CAH) have been followed. Features of PBC, namely the generalized pruritus, massive rise in alkaline phosphatase, antimitochondrial antibodies and high levels of IgM-globulins, were present in 7 patients with CAH. This group was treated with immunosuppressive drugs for 1-2 years. Clinical, biochemical, immunological and histological parameters were used to assess the therapeutic effect. The pruritus improved and there was a statistically significant reduction in the IgG-hyperglobulinemia. Some resolution of the piecemeal necroses was seen. However, in judging these changes the sampling error must be taken into account. The unknown agent attacks both the hepatocytes and the epithelial cells of the bile ducts. The immunosuppressive treatment protects the liver cells from further damage while the progressive destruction of the bile ducts remains uninfluenced. The results suggest that the smallest possible dose sufficient to suppress the activity of CAH must be selected.

Alkaline Phosphatase↗
PubMed1977

[Dihydralazine-induced acute hepatitis with IgM deficiency].

Two patients with IgM-deficiency developed acute, recurrent HB3-Ag negative hepatitis with bridging necrosis following ingestion of low daily doses of dihydralazine. The association between the drug and the liver disease appears probable, as recurrence of hepatitis followed each exposure. One patient developed high titers of antimitochondrial antibodies and the other low titers of antibodies against smooth muscles. The relationship between IgM-deficiency and dihydralazine hepatitis is not clear. Investigation of patients with IgM-deficiency for drug hypersensitivity and liver disease may provide additional information.

Acetylation↗
PubMed1977

[Early diagnosis of hepatic duct carcinoma].

8 patients with carcinoma of the hepatic duct are presented. Despite symptoms during the long anicteric period (2-13 months, x 15 months) the diagnosis was never established until the patients became jaundiced. Early in the course of the diseases all of them reported upper abdominal pain and intermittend diarrhea, and the test for occult blood in the stool was positive. Initially there may be no biochemical evidence of cholestasis. Liver biopsy may at an early stage reveal pseudoxanthoma cells as an index of long-lived, local mechanical cholestasis.

Abdomen↗
PubMed1976

[Liver metastases: diagnostic value of blood tests, scintiscanning, and laparoscopy (author's transl)].

In 90 patients with known extra-hepatic malignancy the liver was examined for metastases. The diagnostic value of clinical information, blood examinations, 99mTc scintiscan, and laparoscopy for the diagnosis of the liver metastases was evaluated. Clinical data (age, sex, time since onset of symptoms and localisation of primary tumor) are of no diagnostic value. The most reliable blood tests are alkaline phosphatase (AP) and GOT. The probability of liver metastastases rises with increasingly abnormal values of AP and GOT. However, the probability is not much greater in cases with highly abnormal values than in cases with only moderate elevation of AP and GOT. Diagnostic accuracy of AP is optimal by using a cutoff point of 76 U/l (sensitivity 79%, specificity 64%). Bilirubin, prothrombin time, haemoglobin and blood sedimentation rate are of very little value. Combinations of AP with these blood tests does not improve diagnostic accuracy. Therefore, it is not useful to determine more blood tests than AP alone. Informed reading of liver scans has a specificity of 75% and a sensitivity of 91%. Blind reading of scans has a sensitivity of 94% and a specificity of 95%. This diagnostic accuracy cannot be improved by additional blood tests. Laparscopy has a sensitivity of 85% and a specificity of 95%. Scanning and laparoscopy are complementary methods. When optimal diagnostic accuracy is required both methods should be used.

Adult↗
PubMed1975

[Pleural effusion: a symptom of acute and chronic hepatitis].

3 cases of acute and 2 of chronic aggressive hepatitis associated with pleural effusion are presented. Pleural effusion in this setting is a rarity and always occurs in the early phase of acute hepatitis or during exacerbations of chronic aggressive hepatitis. It disappears with normalization of liver function tests. The exudate is rich in protein (3-4 g %) and contains lymphocytes as well as erythrocytes. In 2 cases Australia-antigen (HBs) could be documented. An immunological mechanism is suggested.

Acute Disease↗
PubMed1975

[Chronic hepatitis].

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Antibodies, Antinuclear↗