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B D Andresen

Publications and source records attributed to B D Andresen.

31 records · Page 2Linked to original sources
PubMed1979

Identification and synthesis of a methylated catechol metabolite of glutethimide isolated from biological fluids of overdose victims.

Urine samples from victims severely intoxicated by glutethimide were hydrolyzed enzymatically. TLC, GLC, and mass spectral analyses revealed a methylated catechol metabolite of the parent drug. Two synthetic pathways are described for the preparation of 2-ethyl-2-(3-methoxy-4-hydroxyphenyl)glutarimide and 2-ethyl-2-(3-hydroxy-4-methoxyphenyl)glutarimde. Comparisons of GLC and mass spectral data to a compound isolated from the body fluids of glutethimide overdose victims conclusively identified a new 3-methoxy-4-hydroxyphenyl metabolite of glutethimide in humans.

Catechols↗
PubMed1977

Toxicity of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide in human urine.

A novel metabolite, alpha-phenyl-gamma-butyrolactone, isolated from the urine of a glutethimide overdose victim, was synthesized and tested for biological activity in mice. Interperitoneal injections of this lactone caused severe toxicity at moderate dose levels. These results point to another metabolite of glutethimide contributing toxicity to patients severely intoxicated by the parent drug. An improved synthesis as well as complete spectral data of this lactone are also presented.

4-Butyrolactone↗
PubMed1976

Synthesis and characterization of a catechol metabolite of glutethimide (Doriden) in human urine.

A metabolite of glutethimide, 2-ethyl-2-(3,4-dihydroxyphenyl)-glutarimide, previously identified in enzymatically hydrolyzed human urine of overdosed victims was prepared synthetically and its chemical and spectral data compared to the proposed material. Results of these comparisons confirm the presence of a catechol metabolite of glutethimide in the urine of patients severely intoxicated by the parent drug.

Catechols↗
PubMed1976

Synthesis and characterization of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide, phenobarbital and primidone, in human urine.

A novel metabolite, alpha-phenyl-gamma-butyfolactone has been isolated in urine samples of patients severely intoxicated by either glutethimide, phenobarbital, or primidone. This lactone was prepared synthetically and its spectral data and chromatographic properties were compared to those data obtained from the urine samples of drug overdosed victims. The results of these comparisons confirm the presence of this lactone in human urine following the ingestion of large amounts of the parent drug.

Glutethimide↗
PubMed1975

Phenolic metabolite, 2-ethyl-2(4-hydroxphenyl)-glutarimide in human urine following chronic ingestion of glutethimide (Doriden).

Urine samples from comatose patients, identified as having taken large amounts of the drug, glutethimide, were analyzed using gas chromatography, mass spectrometry, thin layer chromatography, and nuclear magnetic resonance spectrometry in order to identify metabolites of the parent drug. The phenolic compound 2-ethyl-2-(4-hydroxphenyl)-glutarimide was fully characterized as a new metabolite in human urine. Also 2-ethyl-2-(3-methoxy-4hydroxyphenyl)-glutarimide was proposed as a new metabolite of the parent drug. Other polar metabolites of the parent drug were also detected and partially characterized.

Chromatography, Gas↗
PubMed1975

Definitive characterization of the para-hydroxyphenyl metabolite of glutethimide in human urine.

The compound, 2-ethyl-2-(4-hydroxyphenyl)-glutarimide was prepared synthetically. Spectral data is presented which identifies this compound to be a metabolite of glutethimide isolated from enzymatically hydrolyzed human urine, following an overdose of the parent drug. New data supporting the structure of a minor metabolite, 2-ethyl-2-(3-methoxy-4-hydroxy)-glutarimide, is considered. Finally, gas chromatographic techniques have been perfected and are presented which yield complete purification of new metabolites of glutethimide.

Chromatography, Gas↗
PubMedDate not supplied

Chemical and elemental comparison of two formulations of oleoresin capsicum.

In-custody deaths following the application of pepper spray weaponry by law enforcement personnel have increased in California over the last few years. Oleoresin capsicum (OC), an oily extract of hot peppers, is the active ingredient in the spray, but little detailed information on product mixtures is available. Since OC extracts contain a multitude of natural compounds at irregular concentrations, there could be considerable, variation in overall chemical composition among the different formulations of both 'natural' and 'synthetic' OC preparations. This was confirmed by organic and inorganic analyses performed on OC sprays produced by two manufacturers licensed for distribution within the state of California. The results indicated that the differences could lead to considerable inconsistency in weapon effectiveness, and suggested that more comprehensive studies are warranted.

Aerosols↗
PubMedDate not supplied

Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine.

The metabolism and excretion of acebutolol-d6, [1-(2-acetyl-4-n-butyramido-phenoxy)-2-hydroxy-3--[2H6]isopropylaminopropane] has been studied in the rat. Metabolites were characterized by thin-layer and gas chromatography, mass spectrometry, and the direct comparisons of metabolites to synthetic standards. Approximately 60% of the parent drug was excreted unchanged. Two major metabolites, an acetamide and an aniline, were identified in urine samples at relative concentrations of approximately 10% and 30%, respectively. The aniline analog of acebutolol was also identified in human urine.

Acebutolol↗