Biomedical subjects
Publications and source records attributed to B D Buchanan.
A new kindred with elevated levels of serum thyroxine-binding globulin (TBG) as an inherited trait has been reported. Of the twenty-four family members tested, three males and nine females had elevated serum TBG. The pedigree was consistent with an X-chromosome linked mode of inheritance.
Two cases of disseminated atypical tuberculosis are presented in which the infection anteceded by over four years the development of acute granulocytic leukemia on one and Hodgkin's Disease in the other patient. The presence of disseminated atypical mycobacteriosis in the absence of a clearcut underlying illness suggests a "preneoplastic state." It should alert the clinician to the possibility of a neoplastic disorder which may not become clinically manifest for several years.
Three cases of delayed development of pleural effusion under tension, 20 to 30 years after therapeutic pneumothorax, are described. A sudden increase in dyspnea and the radiographic findings of increasing opacity, a change from hypovolemia to hypervolemia of the hemithorax, and mediastinal shift should alert one to this delayed complication. Careful thoracentesis to decompress intrapleural tension effusion can relieve the dyspnea and improve hypoxemia. The potential risks of creating excessive negative intrapleural pressure are presented.