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Biomedical subjects

B Dökert

Publications and source records attributed to B Dökert.

At least 19 recordsLinked to original sources
PubMed1989

[Cimetidine and ethanol].

Cimetidine inhibits hepatic drug metabolism, but its effect on ethanol elimination is less well established. The influence of cimetidine on the kinetics of ethanol is studied with three standardized drinking experiments. Cimetidine had no influence on the absorption or elimination of ethanol. There were significant differences in distribution of ethanol in consequence of inhibition of vascular histamine receptors after cimetidine application.

Adolescent↗
PubMed1989

[Treatment of cholecystolithiasis from the internal medicine viewpoint].

There is no better treatment method for the cholecystolithiasis accompanied by symptoms than the cholecystectomy. In the so-called mute gall an expecting attitude is justified. During the last years for selected patients with gallstones and calculi in the common bile duct, respectively, non-surgical therapeutic methods were developed. So it is possible for carriers of gallstones with slight to moderate complaints to undergo a medicamentous trial of litholysis with chenodesoxycholic acid or ursodesoxycholic acid or above all with a combination of these two bile acids. X-ray-negative calculi of less than 1.5 cm with a functioning gallbladder are the prerequisite. The extracorporeal stoss-wave lithotripsy is a new interesting method as well as the percutaneous or retrograde instillation of methyl-butyl ether. In these cases we are at the beginning, the international development should be pursued with attention. In calculi of the bile duct apart from operative methods the papillotomy and the extraction of calculi more than stood the test. The stoss-wave lithotripsy in calculi of the bile duct, which are to be removed neither by instillation of solvents nor endoscopically is a way out of the difficulty in contrast to the operation. As it is evident from the demonstrated facts the cholecystectomy, as the Swiss surgeon Rewbridge remarked already over 50 years ago, is really not the last answer to the problems of the cholelithiasis. Today it is the point to use the method best suited for the patient.

Chenodeoxycholic Acid↗
PubMed1975

[Immunopathological phenomenona in liver diseases].

More than 400 patients with acute and chronic liver diseases as well as non-hepatic diseases (control group) were examined for the existence of antibodies against mitochondria, smooth musculature and cytoblasts with the help of the immunofluorescence-serological method. The proof of the hepatitis-B antigen was carried out by means of the transmigration-electrophoresis. Auto-antibodytitres larger than 1 : 160 (limiting titres) could be established only in the chronically aggressive hepatitides and the chronically destructing non-purulent cholangitides. Whilst in the chronically destructing non-purulent cholangitides dominate high mitochondrial antibody-titres, in the chronically aggressive hepatitides the antibodies against smooth musculature and/or cytoblasts are dominating. When the hepatitis-B-antigen was present in all groups of diagnosis auto-antibody titres of 1 : 160 were not transgressed. The kind of the antibody-spectrum and the size of the antibody-titres seem to be suitable for the differential diagnosis. High mitochondrial antibody-titres in women are suspicious of a chronically destructing non-purulent cholangitis. High titres of antinuclear antibodies or such ones against smooth musculature might be a reference to the so-called auto-immune form of the chronically aggressive hepatitis. For a still better differentiation of the chronic liver diseases the determination of these antibodies seems to be valuable.

Animals↗