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Biomedical subjects

B De Waele

Publications and source records attributed to B De Waele.

14 recordsLinked to original sources
PubMed1990

Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma.

We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.

Appendiceal Neoplasms↗
PubMed1989

Surgical treatment of a retroperitoneal neurofibroma in von Recklinghausen's disease.

The rare occurrence of a retroperitoneal neurofibroma in a patient with von Recklinghausen's disease is presented. Malignant degeneration of a benign neurofibroma is a common threat in neurofibromatosis and cannot be definitely excluded by actual means. Therefore complete surgical removal of the retroperitoneal mass, even in asymptomatic patients, is advocated.

Humans↗
PubMed1987

Peritoneovenous shunt for pancreatic ascites.

A chronically ill patient with pancreatic ascites was successfully treated with a temporary LeVeen peritoneovenous shunt. This observation supports the use of a peritoneovenous shunt in the treatment of pancreatic ascites which is refractory to medical therapy and not amenable to major pancreatic surgery.

Adult↗
PubMed1985

Nonparallelism of digestive enzymes in rat pancreatic hypersecretion.

During a 4 days' cannulation of the pancreatic duct in conscious rats, pancreatic hypersecretion developed. The enzymic composition of the juice altered with time. Amylase secretion reached a plateau after 24 h, whereas the lipase secretion continued to increase for 48 h. The mean trypsinogen and chymotrypsinogen output was three times greater on the 4th day than during the first 24 h. The intrapancreatic content of the enzymes diminished with a different disappearance rate for each enzyme. After 96 h the pancreas contained only 15% of the initial amounts of amylase; lipase also decreased to 15%, chymotrypsinogen to 32% and trypsinogen to 42% of the basal value. Comparison of the rates of synthesis of enzymes on the 1st and the 4th days of study showed an increase of 89% for amylase, 291% for trypsinogen, 300% for chymotrypsinogen and 759% for lipase. It is concluded that the nonparallel content and secretion of digestive enzymes during the course of several days pancreatic hypersecretion is due to different synthesis rates for each enzyme.

Amylases↗
PubMed1984

Carcinoma of cystic duct leading to obstructive jaundice.

Twenty-one cases of primary carcinoma of the cystic duct have been reported in the literature. Most cases were characterized by a hydrops or cholecystitis, whereas only two patients presented with jaundice. To our knowledge, this is only the third case of obstructive jaundice caused by a primary cystic duct carcinoma. The patient was treated by cholecystectomy with resection of the cystic duct tumor and a portion of the common bile duct. Reconstruction was performed by a Roux-en-Y choledocojejunostomy.

Adenocarcinoma, Papillary↗
PubMedDate not supplied

Gallstone pancreatitis in adolescents.

Two female adolescents, 16 and 18 years of age respectively, had to be operated for gallstone pancreatitis. They represented 2.2% of all patients with this disorder, admitted from 1978 to 1987 in our department. In one patient cholelithiasis was associated with obesity, in the other there was a positive family history of gallstones. Congenital anomalies of the biliary tract, hemolytic disorders, early pregnancy and other predisposing factors were absent. Although unfrequent, gallstone pancreatitis is a serious cause of acute abdominal distress in adolescents which can lead to severe morbidity. Adequate biliary tract surgery is curative.

Acute Disease↗
PubMedDate not supplied

Upper gastrointestinal bleeding due to benign tumours of the stomach.

Benign tumours of the stomach are usually asymptomatic and are discovered incidentally during radiology, endoscopy or pathological examination. In some cases, however, these tumours produce overt clinical symptoms. The authors report eight patients with significant upper gastrointestinal bleeding due to benign gastric tumours, who required surgical resection of their lesion. Histologically, the growths proved to be leiomyoma in five cases, polyps in two and lipoma in one. Surgical treatment consisted in local excision in three patients and subtotal gastrectomy in five patients. Bleeding was stopped in all cases and there was no operative mortality.

Aged↗
PubMedDate not supplied

Retroperitoneal leiomyosarcoma.

The clinical history, radiological investigations, pathologic findings and treatment of four patients affected by retroperitoneal leiomyosarcoma were compared with data of the literature. These tumors have a great tendency to develop local recurrences after excision, but metastases to lymph nodes and distant organs usually occur lately. CT examination of the retroperitoneal space is a sensitive tool in the diagnosis and follow-up. Complete excision of the tumor followed by radiotherapy improves significantly the prognosis. Chemotherapy is advisable only when disseminated metastases appear. No correlation was found between the histologic appearance and the clinical behaviour.

Adult↗
PubMedDate not supplied

Endometriosis of the appendix.

Endometriosis has been encountered in different sites of the gastrointestinal tract. Involvement of the vermiform appendix, however, is rather unusual. Two cases of appendiceal endometriosis are reported in the present study: one patient had symptoms simulating acute appendicitis; in another patient it was an incidental finding during pelvic surgery. There are no clinical signs and findings pathognomonic of endometriosis of the appendix, but the condition may present as appendicitis. At surgery, the diagnosis can only be suspected when it is associated with obvious genital endometriosis. Correct diagnosis is established by microscopic examination of the lesion. Symptomatic endometriosis of the appendix will be cured by appendectomy.

Adenocarcinoma↗
PubMedDate not supplied

Endometriosis and small bowel obstruction.

Pelvic endometriosis, a common disease of the female genital tract, may also affect the bowel, especially the rectosigmoid colon. Involvement of the small intestine occurs very infrequently. A case of small bowel obstruction caused by ileal endometriosis is reported. Correct preoperative diagnosis is very difficult to achieve. The association of gynecologic complaints with intestinal symptoms in women of childbearing age is characteristic, but the clinical history may be extremely variable. Small bowel roentgenography can be helpful and ultrasound examination offers new diagnostic possibilities. Endometriotic obstruction of the small bowel should be treated by resection of the involved segment.

Adult↗