PubMed Health⌕ Search

Biomedical subjects

B Delaloye

Publications and source records attributed to B Delaloye.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Factors aggravating the anemia in chronic hemodialysis: destruction or loss?].

Sixteen out of 78 patients (20.5%) on chronic hemodialysis had a mean hematocrit below 0.20 L x L-1 during a six months follow-up period. Three of the 16 had been previously binephrectomized. Eleven of the remaining patients were investigated by 51Cr labelling of red cells. Blood loss in the dialyzer and blood lines was measured at 2.72 +/- 1.90 ml of red blood cells (0.97-7.31). Occult intestinal blood loss was detected in 2 patients. Clinically latent hypersplenism was evidenced in all patients, as demonstrated by an increased splenic-cardiac ratio (99.5 +/- 38% and a decreased red blood cell half-life (16.3 +/- 2.3 days). Hypersplenism and blood loss during dialysis are two underestimated but major contributory factors in the increased anemia observed in chronically hemodialyzed patients.

Anemia↗
PubMed1977

Extrapancreatic effect of glibenclamide: stimulation of duodenal insulin-releasing activity (DIRA) in man.

Experiments were performed in order to study a possible participation of gastrointestinal factors in the insulinotrophic action of glibenclamide in man. Six healthy volunteers received 5 mg glibenclamide in 50 ml saline orally. Biopsies were taken from the duodenal mucosa before and after administration of the drug. The duodenal insulin-releasing activity (DIRA) was assayed in the extracts of the biopsy material by using an in situ pancreas preparation of rat. The corresponding drug, IRI and glucose levels were measured in peripheral blood. The values of IRI correlated with both the prior elevation of DIRA and the increasing levels of the drug in the blood. These data indicate that glibenclamide might stimulate the release of gut factor(s) which, in turn, could possibly sensitize the pancrease response to the drug.

Adult↗
PubMed1976

Pre-operative localization of hyperfunctioning parathyroid tissue by parathyroid scintigraphy.

In 22 patients who underwent surgery suspected of primary hyperparathyroidism, the surgical findings were compared with the results obtained by pre-operative parathyroid scanning and biochemical screening. Thirteen of 15 parathyroid adenomas were localized by pre-operative scanning, but in five of them a false positive focus was also described. The technique was less useful in primary hyperplasia. Comparable results were reported by other investigators. In both instances the best results were obtained in patients with high parathyroid activity as measured by plasma calcium, plasma alkaline phosphatase and tubular reabsorption of phosphorus (TRP). Parathyroid scintigraphy was especially helpful in the presence of ectopic adenomas and in patients who had undergone previous parathyroid surgery. Unfortunately, the possibility of false positive results makes it unreliable for the diagnosis of primary hyperparathyroidism.

Adenoma↗