[Cholestatic hepatitis and acute kidney insufficiency during treatment with diclofenac].
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Biomedical subjects
Publications and source records attributed to B Delmarre.
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The authors report 11 cases of Hodgkin's disease in which the first sign was due to bone involvement. Such observations are rare and raise diagnosis delays (Means: 5, 6 months in this series). Modern medical imaging techniques (scintigraphy, CT scan, magnetic resonance imaging) are very useful to an earlier diagnosis which will be better confirmed by lymph node biopsy given the poor information yielded by osseous cytology and/or histology. The elective localisation in bones belonging to the axial skeleton seems to support the hypothesis of a contiguous osseous involvement from lymphoïd organs in contact with bones. Evolution with chemotherapy and radiotherapy is very similar to that observed in patients without bone involvement.
Nine cases of systemic lupus erythematosus (S.L.E.) among ivoirian Africans seen over a period of eleven years were studied. The pattern of clinical presentations is similar of that seen elsewhere. Photo-sensitivity is not described as in american Negroes. Death is usually due to severe infection. The incidence of the disease among populations of different african countries are compared. The low prevalence 0,18 p. mille may be a function of failure to diagnose the more mild cases.
In 1986 prevalence rates of anti-HIV1 antibodies in randomly selected asymptomatic gabonese population ranged from 0.2% in rural areas to, 1.8% in Libreville (the largest town). We report the first description of AIDS cases observed in the hospitals of Libreville and Franceville between 1985 and 1987. 23 patients (14 males, 9 females) met the clinical diagnosis criteria for AIDS according to the provisional WHO clinical case definition for AIDS. 21 of them were gaboneses. The mean age of patients was 32.8, only one child was observed (blood transfused sickle-cell anemia). The only risk factor that we observed three times was blood transfusion. The clinical presentation of those cases will be described. 22 were positive for anti-HIV1 antibodies by Western-Blot analysis of their sera, one was anti-HIV2 positive (a congolese man hospitalized in Franceville for severe weight loss and pulmonary tuberculosis).
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A lot of european authors demonstrate that echocardiography is the best examination to objective cardiac localizations in rhumatoïd arthritis (RA). Leleu, in a recent publication thinks that the rarity of systemic localizations during RA in Africans is characteristic. The authors examine the last 15 patients. They never find cardiac involvement and this seems to confirm the clinical impression about 50 previous cases.
Schistosoma mansoni infection was diagnosed in 77 patients among 184 men (41.8%) coming from a regiment which had stayed in an endemic area. When it was recognized, this affection had no symptom in 48% of cases. When symptoms were present, they were general or allergic signs, and digestive troubles. Diagnosis, conjectured by hypereosinophilia, was confirmed by discovery of ova in 34 cases, and, in another hand, by positive immunofluorescence in 43 cases without evidence of parasite. This serological test is the best one for diagnosis, at the outset of disease.
A case of multifocal tuberculosis, similar to historic description of the disease is reported in a clear skinned African. Lungs, bones and joints (vertebreae, sternum, os coxae), liver and esophagus were affected by the disease. The low level of resistance found in the patient could explain this dissemination. Generally, prognosis is not compulsorily bad if the germ is sensitive to an additional chemotherapy which needs to be sufficiently prolonged.
This first case has been found in a polynesian woman, a casual finding of the above condition during a whole heart decompensation. Clinical, biological, endoscopic and therapeutic aspects of Plummer-Vinson syndrome are reviewed.
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The authors report a short but homogenous group of 23 cases (15 men and 8 women) of hepatic amebiasis in Yaoundé (Cameroun), all of them confirmed by immunology. They state 2 isolated fevers, 4 jaundices. Nearly all cases were treated by tinidazole with very fast and evident success. One patient was operated and died. The great interest of immunology is underlined for the diagnosis and we wish its generalization, particularly in tropical countries.