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Biomedical subjects

B Dieckhues

Publications and source records attributed to B Dieckhues.

At least 19 recordsLinked to original sources
PubMed1989

[Effect of light on the eye on metabolism and hormones].

Numerous metabolic parameters in serum and urine were examined in 110 cataract patients before and after cataract surgery. The marked reduction in light passing through the eye due to opacities (vision less than 1/10) leads to characteristic metabolic and hormonal disturbances. ACTH and cortisol production decreases, metabolism slows down and due to an adrenal insufficiency for which the pituitary is responsible there are characteristic changes in the cortisol-dependent metabolic processes. In addition, an "energetic action" of the light affecting the hypothalamus via the retino-hypothalamic pathways (the "energetic portion" of the visual pathway) was proved in patients who were blinded by cataract and had metabolic disturbances as a result. Postoperatively, after elimination of the lens opacities, the metabolism and hormones of the same patients returned to normal. As a result of restoration of exogenous light stimulation to the diencephalon-hypophysis system via the retinohypothalamic pathway ("energetic pathway" of the optic system) the metabolism and hormones returned to normal during the patients' stay in the hospital. These comparative investigations in the same patients before and after cataract extraction provide for the first time irrefutable scientific evidence of the influence of light via the eye on the human organism.

Adrenocorticotropic Hormone↗
PubMed1986

[Value of serologic tumor tests in malignant melanoma of the choroid].

In about 350 patients with malignant melanoma of the choroid 32 serological tumor tests, specific as well as nonspecific, were carried out. Significant differences were found in: leukocyte adherence inhibition test (LAI), electrophoresis mobility test (EMT), carcinoembryonic antigen (CEA), acid alpha-1-glycoprotein (AGP), immunoglobin G, vitamin A, copper, and magnesium. For early diagnosis of malignant melanoma of the choroid the LAI test, together with the examination of immunoreactive lymphocyte subpopulations (helper and suppressor cells) proved to be the most valuable.

Antibodies, Neoplasm↗
PubMed1986

[HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid].

In 19 patients with malignant melanoma of the choroid and 11 controls 20 different metabolic parameters of melanin and melatonin metabolism in urine were examined by high-pressure liquid chromatography (HPLC). Significant differences were found in DOPA, DOPAC, MHPG, alpha-keto-glutaric acid, pseudo-uridine, serotonin, OH-tryptophan and homovanillic acid.

Choroid Neoplasms↗
PubMed1983

[Clinical and immunological studies of Behçet's disease].

8 patients with clinically diagnosed Behçet disease were immunologically investigated. Uveitis was present in 7 of these patients. Although uveitis is a rare presentation of Behçet's disease, it tends to be bilateral when it does occur and to involve both the anterior and posterior segments repeatedly. Nowadays it is rare to observe a hypopyon, thanks to early initiation of therapy. In the late stages, recurrent vitreous haemorrhage complicates the course of the disease and can lead to blindness. HLA-B5 can frequently be demonstrated in patients with Behçet's disease. Detailed serological investigations, as measles hemagglutination inhibition test+complement fixation test (CFT), rubella hemagglutination inhibition test, hepatitis HB2 antigen, adenovirus antigen, varicella zoster CFT, mumps CFT, herpes simplex CFT, anticytomegalovirus IgM and IgG, toxoplasmosis immunofluorescence, tuberculosis Middlebrock-Dubois, were unable to uncover a connection with past or present infections. Determinations of haptoglobulin, lactate dehydrogenase, albumin and ceruloplasmin showed nothing worth remarking. Electrophoresis can indicate the duration of the illness. In 1 patient the lymphocyte adherence inhibition test was abnormal.

Adult↗
PubMed1981

[Immunological examinations in Vogt-Koyanagi-Harada disease (author's transl)].

In eight patients with clinical sure Vogt-Koyanagi Harada-syndrome (VKHS) immunological examinations were performed. We tested whether there were signs of former or present infections (measles HHT and complement fixation test (C.F.T.), rubella HHT, hepatitis HBs-antigen, adenovirus AG, varicella-zoster C.F.T., herpes simplex C.F.T., cytomegaly IgM and IgG, toxoplasmosis immunofluorescence, tuberculosis Middlebr. Dubois). In none of all cases we could find HLA B12. The rheumatic tests, LDH, albumin an electrophoresis, coeruloplasmin and haptoglobin were negative. The uveal pigment failed to stimulate the leucocyte cultures from VKHS-patients in leucocyte-migration-inhibition-test and in leucocyte-adherence-inhibition-test.

Adult↗
PubMed1980

The effect of natural and artificial light via the eye on the hormonal and metabolic balance of animal and man.

Color change of the plaice and frog, and development of the testes in duck are induced by light stimuli via the eye. Eliminating experiences on the frog (Hollwich) and on the duck (Benoit) showed that these stimuli-beside vision-use a separate way, the so-called 'energetic portion' of the visual pathway (Hollwich). In compared studies on blind and on temporarily blind patients involved by cataract in both eyes, we found significant low levels of ACTH and cortisol. The levels normalized after cataract extraction. -Furthermore, we studied the influence of strong artificial illumination (3,500 and 3,200 lx) on healthy persons with considerable and, on the other hand, with minimal difference of their spectral composition to daylight. We found stress-like levels of ACTH and cortisol in the first group. These findings explain the agitated mental and physical behavior of children staying the whole day in school under artificial illumination with strong spectral deviation from daylight. Therefore, to avoid mental and physical alterations, the spectrum of artificial illumination should be largely similar to that of natural light.

Adaptation, Biological↗
PubMed1977

[The effect of natural and artificial light via the eye on the hormonal and metabolic balance of man (author's transl)].

Examinations of hormone levels in blind persons compared with almost blind and people with normal vision and hormone evaluation with increased artificial light exposure show a definite stimulating effect of light on the human hormonal balance. The effect of light is mediated by an intact perception of light by the eye over an "energetic part" of the visual pathway (Hollwich 1948) - hypothalamus - hypophysis - peripheral endocrine gland. Increasing the intensity of artificial light with "neon-tubes" (fluorescent tubes) leads to "light stress" proved by increased hormone production - especially the stress hormone Cortisol. The belief that artificial light is the same as natural light and that it can fully replace it, is inappropriate in the medical view and needs correction.

Adrenocorticotropic Hormone↗