PubMed Health⌕ Search

Biomedical subjects

B Dimitrov

Publications and source records attributed to B Dimitrov.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Treatment of peptic ulcer using proglumide (Milid)].

20 patients with peptic gastric ulcer and 30 patients with peptic duodenal ulcer were treated with Milid (Proglumid). The following results were achieved: in 85% of the patients with peptic gastric ulcer and in 93% of the patients with duodenal ulcer the pain was relieved on the 4th day on the average. In 95-96% of the patients treated the dyspeptic complaints disappeared on the 2-3 day. The endoscopic examination performed on the 20th day revealed full epithelization of the ulcer in 30% of the patients with gastric ulcer and in 43.3% of the patients with duodenal ulcer. Following the treatment course the basic secretion and acid production fell statistically significantly in the patients with gastric ulcer while in the patients with duodenal ulcer the basic and stimulated secretion and acid production were suppressed. The drug Milid does not change the serum gastrin level but suppresses the gastrin secretion in the gastric juice. The Milid treatment leads to an increase of the quantity of the N-acetylneuraminic acid in the gastric juice which partly reflects the cytoprotective action of Milid. The drug can be used in the everyday practice for the treatment of peptic ulcer.

Adult↗
PubMed1989

[Biotidin treatment of duodenal ulcer].

The results of the treatment with the Bulgarian drug biotidin of 30 patients with endoscopically proved duodenal peptic ulcer are presented. The drug was given in a dose of 150 mg twice daily in the course of 20 days. The pain ceased up to the third day in 93.3% of the patients treated and the dyspeptic complaints vanished up to the second day of treatment in 96.6% of the patients. Following the treatment a statistically significant lowering of the indices of gastric secretion (V abd V1) and acid production (BAO, MAO, PAO) was found compared to those before the treatment. Endoscopically full epithelialization was found in 63.3% of the patient, in 33.3% of the patients the size of the ulcer diminished and in only 3.4% of the patients there was no change of the ulcer size. The ulcer epithelialization was related to the initial ulcer size. The results achieved do not differ substantially from those achieved with the English drug Zantac. In the course of treatment with biotidin no side effects were observed and no changes of the basic biochemical indices were found.

Adult↗
PubMed1987

[Treatment of stomach ulcer with the Bulgarian preparation Farmaxolon].

Thirty-four patients with gastric ulcer were treated with the new Bulgarian preparation pharmaxolon-Pharmachim, for 20 days under clinical conditions. A favourable effect on the clinical symptoms by the pharmaxolon treatment was established but the differences with the control placebo group were statistically insignificant. A total of 47.1% from the gastric ulcers were healed after 20-day treatment and in 32.3% were reduced in size but here the difference from the control placebo group was insignificant. Pharmaxolon, with its therapeutic effect equals the related foreign (Biogastrone, Ultranyl, Caved-S) and Bulgarian preparations (Alcid-V), hence it is recommended for the practice. Elevated transitory arterial pressure was observed in 41% of pharmaxolon-treated patients, not necessitating the discontinuation of the treatment. That requires a periodic control of the arterial pressure of the patients, treated with that new Bulgarian preparation.

Carbenoxolone↗
PubMed1987

[Treatment of duodenal ulcer with the Bulgarian preparation gastralgin].

The effect of the new Bulgarian preparation gastralgin was studied in 20 patients with duodenal ulcer. The preparation was given three times daily in the course of 20 days--I bag, 1/2 to 1 hour before meals and in the evening before going to bed. Gastralgin contains in one bag--alginic acid 0.500, sodium alginate 0.500, aluminium hydroxide 0.200, magnesium hydroxide 0.100, calcium carbonate 0.500 and corrigent up to 7g. Favourable effect on the separate symptoms was attained in 50 to 80% after the treatment, epithelialization of the ulcer in 40% and reduction of its size in 25%. No change in gastric secretion was observed. Gastralgin, with its therapeutic effect, is equivalent to the preparations almagel and flatugel and their improved variants. The preparation is well tolerated and gives no adverse effects, hence it is recommended for the treatment of duodenal ulcer.

Adult↗
PubMed1987

[Effect of Pharmachim's cimetidine preparation in 200- and 1000-mg ampules on the gastric secretion of duodenal ulcer patients].

Gastric secretion was studied in 30 patients with duodenal ulcer. The trial was carried out in the following way: the patients were divided into two groups of 10 patients each. To the first group of 10 patients on the first day of the examination pentagastrin test was performed by subcutaneous application of Acignost (GDR) in a dose of 6 micrograms/kg body mass; on the second day the same dose of Acignost was injected with simultaneous i. v. application of 200 mg of Cimetidin-Pharmachim. To the second group of 10 patients on the first day pentagastrin test was also performed but on the second day the same dose of Acignost was injected together with 1000 mg of Cimetidin. The i. v. application of 200 mg and 1000 mg of Cimetidin-Pharmachim inhibits significantly the gastric secretion and acid production in patients with duodenal ulcer stimulated by Acignost. The inhibiting action of Cimetidin begins 30 minutes after its application and lasts more than an hour and is better expressed by injecting of 1,000 mg than of 200 mg Cimetidin-Pharmachim. Cimetidin-Pharmachim for parenteral application exerts a strong inhibiting action on gastric secretion and acid production. Its use is recommended for everyday practice since its efficacy equals that of the English drug Tagamet (Smith Kline) for parenteral application.

Bulgaria↗
PubMed1986

[Case of sarcoidosis with predominant involvement of the liver and lymph nodes].

After brief literature data, a clinical case is reported with generalized sarcoidoses with predominant affection of liver and lymph nodes. A detailed clinical-laboratory characteristics is presented and the diagnosis has been histomorphologically objectivized. The hepatocytes were electron-microscopically studied and disorders in carbohydrate metabolism established with predomination of glyconeopoiesis. Bacterial-like structures were established in hepatocytes, providing grounds to look for further possibilities in that aspect for throwing light upon the etiology of sarcoidosis. The clinical case presented confirmed the high diagnostic value of liver biopsy in sarcoidosis, even in the cases with obvious extrahepatal localization of the changes. The therapeutic effect attained confirms, once again, the therapeutic possibilities of the corticosteroids, administered in proper doses.

Biopsy, Needle↗
PubMed1986

Somatosensory evoked potentials upon electrical stimulation triggered by voluntary movement.

The autotriggered signal was presented with a varying delay. SEP obtained without movement of the thumb (control series), SEP of autotriggered stimuli and movement-related brain potentials (MRBP) without stimuli were registered. The EEG was recorded from C3 + 2 and C3 = 2. The following results were obtained: the amplitude of all components diminished when the stimulation was autotriggered compared to the control series; the suppression was most pronounced with a stimulus delay about 150-200 ms; the effect of the suppression did not disappear up to 500 ms after the beginning of the movement.

Brain↗
PubMed1985

Brain potentials related to the beginning and to the termination of voluntary flexion and extension in man.

The presence of brain potentials related to the end of a sustained isometric contraction prompted this study. Potentials related to the beginning of simple ballistic flexion of the index finger were compared with isometric contraction, potentials related to the termination of the isometric contraction, and potentials related to ballistic extension of the reposed index finger. The electroencephalograms recorded in 10 healthy volunteers from scalp positions C3+2, Cz, C3-2 were averaged time-locked to the appropriate mechanograms. Both negativity preceding and positivity following execution of movement were better expressed with simple flexion movements. The negativities preceding all four types of movements were of comparable magnitude whilst the positivities differed significantly. These findings were considered as supporting the ideas of general facilitation preceding preparation for action and specific feedback information following execution, the changes being more prominent over postcentral leads. The existence of potentials related to the termination of voluntary sustained isometric contraction implied a separate command for antagonistic muscles.

Adult↗
PubMed1984

[Treatment of duodenal ulcer with Zantac-ranitidine].

The results from the treatment with the preparation Zantac -Ranitidine of 30 patients with duodenal ulcers are reported. The treatment was carried out with 2 X 150 mg ranitidine daily for 20 days. As early as the second or third day after the initiation of the treatment, the pain disappeared in 96,6 per cent, the sense of heaviness and eructation -- in 100 per cent, pyrosis and palpation pain -- in 96,6 per cent an nausea - in 93,3 per cent. All indices of the gastric secretion (V, BAO, MAO and PAO) were reduced with a statistical significance after 20-day ranitidine treatment, as compared with the initial values. Epithelization (healing) of the ulcer was fibroendoscopically established in 73,3 per cent by 20th day, and by 40th -- in 93,3 per cent. The bigger ulcers were more slowly epithelized . Ranitidine was very well tolerated and gave no adverse effects. Better results, with a statistical significance, were obtained with ranitidine treatment of the duodenal ulcer, both as regards the effect on the subjective symptoms and epithelization of the ulcer as compared with the control group.

Adult↗
PubMed1984

Changes in the Bereitschaftspotential due to subsequent voluntary autotriggered stimulus.

The Bereitschaftspotential (BP) has been studied in two different tasks: simple voluntary isometric flexion/opposition of the thumb and same movement, followed by a mild electrical shock over the median nerve, autotriggered by the movement itself. When the two tasks were organized in separate series, the subject being told about the outcome of the movement beforehand, it was found that: The BP started later; Its amplitude was smaller; The maximum negatively (N2) was smaller, when expecting electrical shock compared to simple voluntary contraction. The decrease was more pronounced over the postcentral areas. When the sequence of the autotriggered electrical shocks was equiprobably intermixed with the simple voluntary presses in single series it was found that virtually no difference existed between different potential measures. This differential influence of equal physical requirements with different subjective sequels upon the potentials related to voluntary movements implied the preferential role of the subject's attitude and state of preparedness upon the brain potentials. Both the elevated stress level and the selective suppression in specific cortical areas might take place in tasks with predictable unpleasant electrical shock.

Action Potentials↗
PubMed1983

[Treatment of duodenal ulcer with biomet].

The results are reported from the treatment of 30 patients with the Bulgarian preparation biomet, which is a blocker of histamine H2-receptors. The treatment lasted 20 days with 3 X 20 mg biomet, after meals, and 400 mg in the evening before going to bed. Pains disappeared in 86,6 per cent with biomet treatment, pyrosis--in 95,8 per cent, eructation--in 95,3 per cent, nausea--in 84,7 per cent, vomiting--in 100 per cent of the patients, etc. (the clinical symptoms completely disappeared in 76,7 per cent after the treatment and were substantially reduced in 16,7 per cent). A statistically significant reduction of the basic parameters of gastric secretion and acid output occurred after biomet treatment as compared with the initial values. The fibroendoscopic study of the duodenal ulcer, after the treatment, revealed a complete epithelization in 52 per cent and diminished ulcer size--in 44 per cent. No pronounced adverse effects were observed during biomet treatment. The Bulgarian preparation biomet is fully equivalent to the English Cimetidine (the latter being more expensive) and should find a broad application in the treatment of duodenal ulcer.

Adult↗
PubMed1983

[Treatment of peptic ulcer with Alcid V].

The results from Alcid V treatment are reported, carried out in the course of 20 days on 39 patients with duodenal and 20 patients with gastric ulcers. A group of 20 patients with duodenal and 10 with gastric ulcers, treated with placebo served as a control under the conditions of double-blind experiment. The pains completely abated in 84 per cent of the patients with gastric ulcer, the pyrosis in 100 per cent, eructation--in 92.3 per cent and the ulcer--in 68.42 per cent, and in the patients with duodenal ulcers--76.9 per cent, 93.10 per cent, 94.3 per cent and 40.62 per cent respectively. As regards the clinical symptoms of gastric ulcers, very good effect was obtained in 76 per cent and good effect--in 24 per cent; in the cases with duodenal ulcers--70.49 per cent and 15.38 per cent respectively. The discrepancy between the effect on the clinical symptoms and on the ulcers (the changes of the latter being endoscopically determined) between the Alcid V treated patients and the control group with placebo are statistically significant. In both groups the gastric secretion (determined by pentagastrin test) is not substantially changed as compared with the values prior to the treatment. Alcid V in the dose administered and the duration of the treatment induced no adverse effects and no essential changes in the biochemical indices; it was well tolerated and could find its application in the treatment of ulcer disease.

Anti-Ulcer Agents↗
PubMed1983

[Clinical trial of the preparation Verbascan in treating gastrointestinal and biliary diseases].

The therapeutic results are presented from the peroral administration of the new Bulgarian preparation Verbascan (spasmolytic, cholinolytic and analgesic), 10 mg three times daily, to 50 patients: with duodenal ulcer--20, with cholelithiasis 10 and dyskinesia of biliary ducts and colon--10 each. In case of duodenal ulcer, the clinical symptoms were very well influenced after 20-day treatment in 65.5 per cent, well in 15.1 per cent, poorly--in 12.5 per cent and without effect in 12.5 per cent and the ulcer faded in 50 per cent, considerably reduced in size in 20 per cent and with no change--20 per cent of the treated (the effect on the ulcer was better, with statistical significance, as compared with the control placebo group). Gastric secretion was not substantially changed by the treatment carried out. The pain and dyspeptic complaints in cholelithiasis were favourably affected in 60 per cent of the treated but the peroral intake did not cope the cholelithiasis crises, rapidly and effectively. Verbascan eliminated and reduced the pains in half of the patients with dyskinesia of biliary ducts and colon, but it had no effect in the pains in the other halt. Verbascan was well tolerated, with no adverse effects, with a favourable ulceroprotective effect, hence it could be used in the treatment of the duodenal ulcer, cholelithiasis and dyskinesia of the biliary ducts and colon with moderate pains.

Alkaloids↗