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Biomedical subjects

B Dore

Publications and source records attributed to B Dore.

70 records · Page 4Linked to original sources

[Alkaline-urine incrusted cystitis. Clinical aspects and treatment].

The authors report 2 cases of a condition often overlooked by the urologist: incrusted cystitis. It shows up clinically with severe urinary troubles and bladder calcifications. In fact the main finding is calcified plaques in the mucosa causing an inflammatory reaction and mimicking a tumor. Histologic examination of endoscopic biopsies rules out tumor and reveals a calcified necrotic mucosa. A high degree of alkalinity of the urine makes the diagnosis of incrusted cystitis after ruling out tuberculosis and bilharziasis. Acidifying the urine clears up the trouble and brings the bladder mucosa back to normal. According to the literature, 3 factors are necessary for the development of incrusted cystitis: a ureolytic microbe capable of releasing ammonia, alkalinity of the urine resulting from this, and a bladder with lesions of cystitis whatever might be the cause. A number of diagnostic errors are possible, but the most serious one is mistaking it for a calcified malignant tumor of the bladder. For this a biopsy is essential to prove the absence of a tumor. The treatment consists of 3 stages: excision of the calcified plaques (mostly by endoscopy), sterilization of the urine (nalidixic acid would be the best agent) and acidification of the urine.

Aged↗

[Use of data processing cards for information retrieval from medical documents. Case reports, bibliographic references, series of observations (author's transl)].

The authors have given pride of place to an old system, punched cards selectors, which are fairly inexpensive to run, and are very flexible in their use. Each card has a part reserved for identification purposes (a case report number or a dated reference to an indexed list of articles) and another part for identification of a certain number of key-words with their corresponding numerical codings, which are also listed in a thesaurus. These key-words serve both for classifying case reports from each department, and for the bibliographic reference cards. When a series of cases are being studied. However, a new thesaurus has to be established during the course of the study. The 960 possible perforations on the international IBM card are largely sufficient as the number of key-words (case reports or bibliographic card-index codings) is not more than 700 and it is unusual to require more than 900 items during the course of a study. The authors find this system very satisfactory and no longer use large computers.

Dictionaries as Topic↗

[Perineal wound with urethral lesion in man. Two cases].

The author reports two cases of perineal wounds with section of the membranous urethra, one operated upon as a delayed emergency (36 hours) and the other as an emergency via a double hypogastric and perineal approach which permitted the opening of the bladder, anterograde catheterisation of the posterior urethra, liberation of the ends of the urethra and their preparation, mobilisation of the anterior urethra and finally end-to-end suture. Both patients seen with a follow-up of 6 months and one year had an excellent mictional result and preservation of erection. The author emphasises the following: --the need for confirming integrity of the bladder by I.V.U.; --the possibility of operating as a delayed emergency after packing of the wound, under cover of bladder drainage via a suprapubic catheter; --the need for a double hypogastric and perineal approach for lesions of the posterior urethra; --the usefulness of urethral catheter for 5 days and drainage of the urine by cystostomy for 3 to 4 weeks. Neither of the patients required secondary dilatation (at least within the limits of the period of postoperative follow-up).

Adolescent↗

A specific alkaline phosphatase of amphibia integument levamisole effect on short circuit current (SCC).

Using the Ussing chamber technique we have measured the short-circuit current (SCC), and so the ion transport, in the ventral skin of samples of Rana esculenta complex. The animals were not exposed to experimental treatment, and on SCC we have observed the effect of levamisole, administered either on external or internal side. Levamisole 0.0025 mM was ineffective; higher concentrations (0.025 mM, 2.5 mM), which inhibit alPase activity in tissue extracts and sections, induced an increase in SCC measurements and the effect was proportional to the concentration. Levamisole 25 mM produced a rapid and transitory increase of SCC, followed by a very quick decrement of it. Because of the action of Levamisole, "specific inhibitor of alPase activity", on ion transport in Rana skin, we propose that the alPase enzyme is probably involved in ion cutaneous transport and thus in the adaptative osmoregulation in the integument of amphibia.

Alkaline Phosphatase↗

Research on cholesterol, steroidal hormones and liposoluble vitamins by thin layer chromatography in some adipose organs of anuran amphibians. II. Liposoluble vitamins.

By means of thin layer chromatography and selective detection, vitamin A acetate, vitamin E and vitamin E acetate, vitamin D3 and cholesterol were identified in the prepericardic body, adrenal tissue, fat bodies and testis of Bubo bufo, as well as in the prepericardic body of Rana esculenta. On the contrary, liposoluble vitamins could not be isolated from the adipose tissue occurring in the thoracic cavity of Rana esculenta, or in Bufo bufo muscles. The results are discussed in correlation with the histological structure of the prepericardic body and the presumptive identification therein of steroid hormones. Lastly, the functional analogy between the prepericardic body and fat bodies in anuran amphibians and the brown adipose tissue of mammals is also postulated.

Adipose Tissue↗

Researches on the development of Xenopus laevis larvae fed on Tubifex tubifex. I. Presence of liposoluble vitamins in the lipid extract from Tubifex worms.

Vitamin E acetate (alpha-tocopheryl acetate) and related tocopherols, vitamin A acetate (dehydroretinyl acetate), vitamin A alcohol (retinol), and cholesterol were identified by thin-layer chromatography in the lipid extract from Tubifex tubifex worms. Compounds (perhaps vitamin D precursors, or seroidal substances) absorbing short wave UV light and/or reacting with antimony trichloride were also present but not identified. The results are discussed in relation to the growth, metamorphosis and possible appearance of malformations in Xenopus laevis specimens reared on Tubifex alone or on diets integrated with Tubifex. The hypothesis of the presence of tossic substances in Tubifex as a cause of malformations in Xenopus is also discussed.

Animals↗