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Biomedical subjects

B Dousset

Publications and source records attributed to B Dousset.

At least 145 records · Page 8Linked to original sources
PubMed1988

One liver for two: an experimental study in primates.

The need for liver grafts is critical in countries where brain death is not accepted as a legal criterion for organ retrieval. This experimental study was conducted with nonhuman primates in order to evaluate the feasibility of liver transplantation using a living donor. An original technique was employed to remove the left part of the liver from the donor: transection of the parenchyma was done while the blood flow was kept to the left part of the liver. In the recipients, the graft was placed heterotopically. No blood transfusions were administered to donors or recipients. In spite of a few failures, due to consequences of intraoperative bleeding, several donor operations using this original technique were successful, in the immediate postoperative period as well as several months later. Among the recipients, the large number of early failures suggests that the heterotopic position is probably not the appropriate one and that orthotopic transplantation should be preferred.

Animals↗
PubMed1985

[Evaluation of the performance of an automatic coagulation tester: the Electra 700].

The Electra 700, an automatic coagulation tester recently available in France, was investigated for its performance on routine tests: Quick's test, APTT, thrombin clotting time test, assay of fibrinogen and prothrombin complex factors. Reproducibility was exceptionally good for Quick's test (CV less than 1%), excellent for the other tests (CV less than 3%), acceptability of the various commercial reagents very good, and standard linearity excellent. There was close correlation with manually obtained (electromagnetic B.M.) or semiautomated (KC 10) results (0.9948 to 0.9345). The apparatus is entirely automatic once specimens have been loaded, and it is particularly adapted to dealing with long series of specimens (60 samples). Its original loading system makes it possible to carry out two types of test concurrently, as well as to insert emergency tests. Economically, the cost of disposables and "reagent loss" is satisfactory; however, all tests are carried out relatively slowly, though this is compensated for by the fact that the reactions are completely automatic.

Blood Coagulation Tests↗
PubMedDate not supplied

Relationship of trace element, immunological markers, and HIV1 infection progression.

Trace elements (selenium, zinc, copper), beta 2 microglobulin levels, CD4, and CD8 cell counts have been determined in 80 HIV1 seropositive patients. The study group consisted of 19 females and 61 males with age mean of 35 +/- 10 yr, at stage IV of infection (CDC--Atlanta classification) and treated by AZT. No severe renal or liver diseases or hypoalbuminemia were observed in this group. Se values were significantly lower than in normal adults, 48.3 +/- 17 micrograms/L vs 71 +/- 12 micrograms/L; Zn was moderately diminished, 1 +/- 0.2 mg/L vs 1.2 +/- 0.2 mg/L, whereas copper values were in the normal range, 1.2 +/- 0.3 mg/L vs 1.1 +/- 0.5 mg/L. Se or Zn deficiency was found in 60 and 30 subjects, respectively. Blood Se and Zn decreases were associated in 23 patients. Moreover, all patients showed higher beta 2 microglobulin values than the upper normal limit of 2.4 mg/L. Negative correlations were found between Zn and beta 2 microglobulin (p < 0.005) and between Se and beta 2 microglobulin (p < 0.05). Moreover, there was a positive correlation between Se and Zn values (p < 0.05). Nineteen subjects died 1 yr later (group I), and 61 remained alive (group II). With respect to the clinical evolution, a significant difference between both groups was found in Se and beta 2 microglobulin levels as well as in CD4 cell counts. The correlations previously observed persisted in group II, whereas no correlation was noted in group I. In addition, the patients of group one had significantly lower Se values, which were below 30 micrograms/L in 10 cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Hepatofugal portal flow in advanced liver cirrhosis with spontaneous portosystemic shunts: effects on parenchymal hepatic enhancement at dual-phase helical CT.

BACKGROUND: We investigated whether spontaneous hepatofugal portal flow in advanced cirrhosis affects hepatic enhancement on dual-phase helical computed tomography. METHODS: Fifteen patients with hepatofugal portal flow on Doppler sonography and angiography (group 1) and 15 age- and sex-matched patients with hepatopetal portal flow (control; group 2) underwent dual-phase helical computed tomography. Vascular and liver attenuation values were measured on unenhanced scans and scans obtained during hepatic arterial (HAP; 25 s) and portal venous (PVP; 70 s) phases. RESULTS: Portal vein enhancement was lower during PVP in group 1 than in group 2 ( p < 0.0001). Liver enhancement was higher during HAP and lower and delayed during PVP in group 1 versus group 2 ( p < 0.0001). CONCLUSION: In hepatofugal portal flow, liver enhancement is increased during HAP and compensating for decreased and delayed liver enhancement during PVP, resulting in potential decreased hypervascular tumor conspicuity.

Collateral Circulation↗
PubMedDate not supplied

Hyperacute rejection in liver transplantation: CT findings.

Hyperacute rejection is rare after liver transplantation. We report a case of early graft failure following liver transplantation in a 46-year-old woman. On the 5th postoperative day, progressive loss of graft function occurred. Liver histology showed submassive hepatic necrosis. Computed tomography features showing large geographic areas of necrosis without anatomic distribution were suggestive of hyperacute rejection.

Female↗