The analgesic action of D-phenylalanine (D-Phe) is well known. It has been demonstrated in hot-plate tests on mice that combining D-Phe with narcotic analgesics already with doses inactive on separate application. In combination with D-Phe, a dose of morphine less by half compared to its unique use does not reduce analgesic activity in rats, but after six weeks of treatment some undesirable side effects like dependence, behavioural disorders and growth retardation are markedly lowered. These results suggest the possibility to design a combined drug similarly effective as well-introduced narcotic analgesics, but better tolerated.

Action Potentials↗

PubMed1988

GU-PACU orientation.

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Ambulatory Surgical Procedures↗

PubMed1985

[Analgesic effect, tolerance development and dependence potential of D-phenylalanine].

In comparison to well-established non-narcotic analgetics, the amino acid D-phenylalanine produces similar, dose-dependent analgesic effects in animal experiments, but acts significantly longer. Neither a tolerance of mice to D-Phe after administration for 10 d nor a development of drug dependence in rats following treatment for 6 weeks could be regarded.

Acetates↗

PubMed1984

[The comparative action of calcium valproate (Convulsofin) with sodium valproate and free acid].

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Animals↗

PubMed1983

[Synthesis and analgesic effect of 2-aryliminomethylquinolines].

2-Aryliminomethylquinolines were synthesized by the condensation of quinoline-2-carbaldehyde with the corresponding anilines. The compounds were evaluated for analgesic activity using the acetic acid writhing test. Some of them showed significant inhibition of the writhing syndrome. The most potent compound 3b was approximately as active as aminophenazone in the writhing and the hot-plate method.

Analgesics↗

PubMedDate not supplied

Epidemic perinatal listeriosis.

During the 11 months beginning in January, 1980, 22 cases of perinatal Listeria monocytogenes infection occurred at three obstetric hospitals in Auckland, New Zealand. Most cases were due to type 1b strains. Since the previous epidemic here in 1969, about one perinatal infection has been diagnosed annually in the same area. Women presented in preterm (11 of 22 cases) or term labor with signs of amnionitis (11 of 22 cases) and associated fetal distress and/or meconium-stained liquor (14 of 19 cases). A mild "flu"-like illness or urinary tract symptoms were common (18 of 22 women). Five fetal deaths occurred. Three were before 20 weeks of gestation. Most liveborn affected babies had early respiratory symptoms (12 of 14 cases). Meningitis occurred in 4 of 14 infants. There was one death. Vaginal carriage of L. monocytogenes was found in only 1 of 750 consecutive asymptomatic pregnant women who were tested at the time of the epidemic. Rectal carriage was found in 25 (3.3%). Pacific Island Polynesians were rectal carriers of L. monocytogenes and were represented among the epidemic cases more often than expected according to birth data (P less than 0.05 and P less than 0.001, respectively). The cause of the epidemic was not discovered but shellfish and raw fish consumption may have played a part.

Adolescent↗

PubMedDate not supplied

Image acquisition context: procedure description attributes for clinically relevant indexing and selective retrieval of biomedical images.

OBJECTIVE: To support clinically relevant indexing of biomedical images and image-related information based on the attributes of image acquisition procedures and the judgments (observations) expressed by observers in the process of image interpretation. DESIGN: The authors introduce the notion of "image acquisition context," the set of attributes that describe image acquisition procedures, and present a standards-based strategy for utilizing the attributes of image acquisition context as indexing and retrieval keys for digital image libraries. METHODS: The authors' indexing strategy is based on an interdependent message/terminology architecture that combines the Digital Imaging and Communication in Medicine (DICOM) standard, the SNOMED (Systematized Nomenclature of Human and Veterinary Medicine) vocabulary, and the SNOMED DICOM microglossary. The SNOMED DICOM microglossary provides context-dependent mapping of terminology to DICOM data elements. RESULTS: The capability of embedding standard coded descriptors in DICOM image headers and image-interpretation reports improves the potential for selective retrieval of image-related information. This favorably affects information management in digital libraries.

Abstracting and Indexing↗