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Biomedical subjects

B Drettner

Publications and source records attributed to B Drettner.

At least 37 records · Page 2Linked to original sources
PubMed1982

Prophylactive treatment with flunisolide after polypectomy.

Twenty-two patients with nasal polyps completed a double-blind study with a new topical corticosteroid, flunisolide. Treatment during three months after operation gave, in comparison with placebo, a statistically significant effect on the symptom of stuffy nose, and on the sum of scores for stuffy nose, runny nose and sneezing. There was no significant effect on rhinomanometry. Side effects were negligible. Three patients in the placebo-group required a further operation within one year but none in the flunisolide group. Prophylactic treatment with flunisolide can be recommended as a complement to other treatment after surgery of nasal polyps.

Administration, Topical↗
PubMed1979

Nasocytologic examination of wood industry workers.

To establish a methodology for field examination for early diagnosis of ethmoidal cancer in workers in the furniture industry, two methods were compared, namely nasal rinsing and direct sample-taking from the middle meatus. The latter method proved superior, resulting in a high number of cylinder cells. This method was tried out in a field survey of 715 furniture workers. No tumours of precancerous changes were revealed. The investigation continues, by exposing the Syrian golden hamster to wood-dust and using, amongst other methods, quantitative nuclear morphometry for evaluation.

Cytodiagnosis↗
PubMed1979

Studies of the effect of peroral fenylpropanolamin on the functional size of the human maxillary ostium.

The effect of peroral fenylpropanolamin on the functional size of the human maxillary ostium was studied in 20 patients suffering from acute rhino-sinusitis. The size of the maxillary ostium was measured by a manometric procedure over a 2-hour period. During the introduction of a known airflow into the sinus for a short while, the pressure increase was compared with a nomogram obtained by model experiments. The introduction of the cannulas into the maxillary sinus caused a swelling of the mucosa in the ostium in the placebo group and initially also in the group receiving fenylpropanolamin, but, after 60 minutes, the latter group had a mean functional ostial size greater than the initial one. These differences were not statistically significant. This seems to be the first objective study of the size of the ostia in the human paranasal sinuses during treatment with a peroral decongestant.

Acute Disease↗
PubMed1977

The invasive pituitary adenoma. A prolactin-producing tumor.

Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, ocular motor signs in two, and epilepsy in two. Most of the patients had symptoms for many years; in two, the tumor was discovered by chance. They all had very high serum-prolactin values. The patients were treated with irradiation, and the prognosis seems to be relatively favorable.

Adenoma↗
PubMed1977

Nasal polyps treated by beclomethasone nasal aerosol.

A double-blind cross-over study of the effect of insufflation of beclomethasone dipropionate 400 microgram per day for four weeks showed favourable results, as verified statistically, concerning nasal blockage at the end of the treatment period. Rhinomanometry also showed that the nasal patency was significantly improved during the beclomethasone period. There was also a tendency, though not statistically significant, for nasal secretion to react favourable. The polyps did not disappear during the active treatment period and short-term treatment with beclomethasone aerosol can thus only be used as an adjuvant to other models of therapy, whether medical or surgical, in nasal polyps. No clinical side-effects of any importance were observed during the study.

Administration, Intranasal↗
PubMed1976

[A clinical method of testing the humidifying capicity of the human nose (author's transl)].

At the beginning attention is drawn to the fact that there is a lack of suitable clinical tests for the measurement of the humidifying and warming capacity of the nose. The great number of testing methods which have been published so far, have been either too complicated to be applied in routine checks or they were too physically strenous, so that this could not be reasonably demanded of the patients. With the help of the clinical method of testing introduced by us one can find out about norm data for the quantitiy of water needed for humidifying the inspired air in healthy persons, as well as examine the influence of pharmacons on the secretion capacity of the nose. In addition to this, pathological states such as atrophic rhinitis, vasomotoric and allergic rhinitis, patients operated with a partial maxillectomy or with total laryngectomy can also be tested as far as the humidifying and warming capacity of the nose ist concerned. In our testing method extremely dry air streams out of a compressed air cylinder with a flow of 8 1/min through a small silicone catheter at the choanal end of one nasal part and is sucked out of the other nostril with a suction flow of 5 1/min, the air passing through a psychrometer modified by us. The excess flow of 3 1/min streams from the naso- into the oropharynx most effectively preventing the air which is to be measured from mixing with the expiratory air saturated with water-vapor. A gas analyzer sensitive to carbon dioxide measures the error possible in this open system which amounts to only one percent of an average mixture with expiratory air. With the help of a psychrometer-normogramme the absolute humidity is determined from the data of the wet and both the dry thermometers. We were testing 22 healthy persons, average age 34, the norm data were established. The result is that for the hole 10 minute measurement period one nasal part needs 1.58 g water for the humidifying of the inspired air. From this it can be calculated that 456 g of water are necessary for humidifying the inspired air through both nasal parts during 24 hours. Compared with other exact methods, which, however, are not suitable for clinical tests (Ingelstedt et al.) our simple and easily workable method correlate very well.

Adult↗
PubMed1975

Investigation of the blood flow in the maxillary sinus.

Plethysmographic measurements of the blood flow in the mucosa of the human maxillary sinus was reported in 1974, but the errors of the method were not completely known. By measuring the absorption of the radioactive gas 133Xe by the antral mucosa simultaneously with plethysmography a comparison between the two methods is possible. A good correlation between the two methods was found in the only subject investigated so far.

Blood Flow Velocity↗