Biomedical subjects
B E Cooper
Publications and source records attributed to B E Cooper.
Lights out. New regulations may treat lighting ballasts as hazardous materials.
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Reinvestigation of a Ca2+/calmodulin dependent neurofilament-directed protein kinase activity.
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Correlation of aminoglycoside and vancomycin pharmacokinetic parameters.
OBJECTIVE: To investigate a correlation between the elimination rate constants (Ke) of aminoglycosides (AG) and vancomycin; to investigate the correlation between actual Ke and creatinine clearance (Clcr) for AG versus vancomycin; to investigate the calculated versus actual Ke for AG and vancomycin; and to investigate a correlation between volumes of distribution (Vd) between AG and vancomycin. DESIGN: Retrospective data collection. METHODS: Patients in our institution who received AGs or vancomycin concomitantly or within six weeks of each other were identified retrospectively. Patient subpopulations were identified and analyzed collectively as well as individually. Steady-state serum concentrations of AG and vancomycin (more than four half-lives) were obtained and kinetic parameters (Ke, Vd) were calculated using first-order pharmacokinetic equations. Linear regression was used to determine correlation coefficients. RESULTS: In the total population and all subpopulations, the correlation between Ke of AG and vancomycin was superior to the correlation between Ke and Clcr. The correlations (r2) between Ke for AG and vancomycin in the total, general medicine, oncology, and intensive care units (ICU) populations were 0.572, 0.878, 0.349, and 0.561, respectively. The correlations (r2) between Ke and Clcr for AG in the total, general medicine, oncology, and ICU populations were 0.235, 0.430, 0.005, and 0.238, respectively. The correlations (r2) between Ke and Clcr for vancomycin in the total, general medicine, oncology, and ICU populations were 0.300, 0.407, 0.055, and 0.309, respectively. CONCLUSIONS: The correlation between Ke of AG and vancomycin may be beneficial for predicting Ke of vancomycin when AG concentrations have already been obtained or vice versa, and may give more accurate estimations of dosing intervals and require less time adjusting, ordering, and interpreting concentrations and dosages.
Theophylline-mexiletine interaction: a case report.
Theophylline and mexiletine can be prescribed in patients with chronic obstructive pulmonary disease with coexistent arrhythmias. The drugs have common metabolic pathways that may result in an interaction. A patient who was taking theophylline became toxic after the initiation of mexiletine. Discontinuation of mexiletine led to an improvement in theophylline clearance.
Implementation of an intravenous potassium policy.
This article explains the rationale and method for implementing a hospital policy for administration of intravenous potassium. The potassium policy is also presented. Because of the potential toxicities associated with potassium, it is very important to have established guidelines for safe and effective administration in an institution. This article will assist readers in developing a policy for their institution.
High-dose phentolamine for extravasation of pressors.
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High serum concentrations of mezlocillin in a critically ill patient with renal and hepatic dysfunction.
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Quality assurance: a team approach.
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The growth of microbial film on vertical screens dosed with settled sewage.
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