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Biomedical subjects

B E Fisher

Publications and source records attributed to B E Fisher.

At least 19 recordsLinked to original sources
PubMed2000

Influence of central set on anticipatory and triggered grip-force adjustments.

The effects of predictability of load magnitude on anticipatory and triggered grip-force adjustments were studied as nine normal subjects used a precision grip to lift, hold, and replace an instrumented test object. Experience with a predictable stimulus has been shown to enhance magnitude scaling of triggered postural responses to different amplitudes of perturbations. However, this phenomenon, known as a central-set effect, has not been tested systematically for grip-force responses in the hand. In our study, predictability was manipulated by applying load perturbations of different magnitudes to the test object under conditions in which the upcoming load magnitude was presented repeatedly or under conditions in which the load magnitudes were presented randomly, each with two different pre-load grip conditions (unconstrained and constrained). In constrained conditions, initial grip forces were maintained near the minimum level necessary to prevent pre-loaded object slippage, while in unconstrained conditions, no initial grip force restrictions were imposed. The effect of predictable (blocked) and unpredictable (random) load presentations on scaling of anticipatory and triggered grip responses was tested by comparing the slopes of linear regressions between the imposed load and grip response magnitude. Anticipatory and triggered grip force responses were scaled to load magnitude in all conditions. However, regardless of pre-load grip force constraint, the gains (slopes) of grip responses relative to load magnitudes were greater when the magnitude of the upcoming load was predictable than when the load increase was unpredictable. In addition, a central-set effect was evidenced by the fewer number of drop trials in the predictable relative to unpredictable load conditions. Pre-load grip forces showed the greatest set effects. However, grip responses showed larger set effects, based on prediction, when pre-load grip force was constrained to lower levels. These results suggest that anticipatory processes pertaining to load magnitude permit the response gain of both voluntary and triggered rapid grip force adjustments to be set, at least partially, prior to perturbation onset. Comparison of anticipatory set effects for reactive torque and lower extremity EMG postural responses triggered by surface translation perturbations suggests a more general rule governing anticipatory processes.

Adult↗
PubMed2000

Deficits in compensatory trajectory adjustments after unilateral sensorimotor stroke.

In a previous study, we demonstrated that the time-course for amplitude specification of goal-directed aiming movements is similar for individuals with and without a unilateral sensorimotor (SM) area lesion. However, subjects with a SM lesion performing with the arm ipsilateral to the side of the brain lesion were significantly less accurate than control subjects in an unpredictable condition. The unpredictable condition requires that subjects both formulate an initial plan for movement as well as adjust the response later as additional information about the target (i.e., the goal) is gained. It has been demonstrated that premovement planning and compensatory adjustments are the processes contributing largely to accuracy in targeted, isometric force responses. A statistical model has been described, which partitions response trajectories into the planned and compensatory adjustment components. The purpose of this study was to apply the statistical model to our previous data to determine if the difference in accuracy in those with unilateral stroke was due to a deficit in premovement planning, compensatory adjustments, or a combination of these two factors. We compared the performance of six subjects with unilateral stroke to that of matched control subjects participating in a timed-response movement paradigm. Subjects rapidly flexed or extended the forearm in order to capture a short (20 degrees) or long (45 degrees) target presented in either a fixed (predictable condition) or a random sequence (unpredictable condition). For individuals with stroke, the limb used was that ipsilateral to the side of the SM lesion. Time to prepare the response was manipulated by varying the time of target presentation relative to an auditory cue for movement initiation. Velocity was derived from the displacement data, and multiple regression was used to determine the effect of premovement planning and compensatory adjustments on end-point accuracy. In the predictable condition, premovement planning contributed to final position more for the subjects with stroke [mean (SEM) = 0.50 (0.02)] than for the control subjects [0.36 (0.03)]. In the unpredictable condition, there were no differences between groups in percent variance due to planning [0.54 (2.1) for the stroke group and 0.45 (2.8) for the control group]. This suggests that the ipsilateral (i.e., intact, undamaged) SM hemisphere significantly participates in the premovement planning of an aiming action. In contrast, for both predictable and unpredictable conditions, compensatory adjustments accounted for a smaller percentage of the variability in final position for the subjects with stroke than for the control subjects [0.09 (2.2) for the stroke group and 0.25 (4.8) for the control group]. Therefore, the less accurate responses for the stroke group can be explained by deficits in the compensatory adjustment component. This suggests a substantial role for SM areas in the preparation and implementation of corrective actions while the effects of the pre-planned action are unfolding. In particular, we discuss the role of the ipsilateral SM areas in relation to parallel feedforward processing in unimanual aiming.

Aged↗
PubMed1999

Organic: What's in a name?

The organic foods industry is booming: by one estimate, the market for organic foods is worth $4 billion annually and is expected to grow at a rate of more than 24% per year. Faced with the threat of pesticide exposures and other food safety problems, many consumers are turning to organic foods in hopes of finding a healthy alternative, but there is currently no consistency in organic food labeling and no guarantee that foods labeled as organic are actually grown and processed in a purely organic fashion. There is also controversy about whether the label "organic" covers such new technologies as irradiation and genetic engineering. As part of the 1990 Farm Bill, the U.S. Department of Agriculture (USDA) is working to develop a proposed rule on organic foods. The rule would regulate the allowable methods, practices, and substances used in producing and handling crops and their processed products. The first draft of the proposed rule, released in December 1997, met with unprecedented opposition, which centered around the fact that the proposal appeared to virtually ignore the recommendations of a standards board formed to assist in the rule's development. Other criticism opposed three practices put forward for comment by the USDA: irradiation, genetic engineering, and the use of sewage sludge in farming. Due to the vehemence of the opposition to its original proposal, the USDA has decided to rewrite the proposed rule. In preparation for that proposal, the USDA Agricultural Marketing Service released three issue papers in October 1998 for public comment. The 10,000-plus comments received in response to those papers will be incorporated into the second draft proposal, due out later this year.

Agriculture↗
PubMed1999

Most unwanted.

Persistent organic pollutants (POPs) can travel thousands of miles, accumulate in the food chain, and persist in the environment, taking as long as centuries to degrade. POPs are known to play a role in birth defects, cancer, immune system dysfunction, and reproductive problems in wildlife. While the effects of POPs on human health are unclear, many researchers believe that long-term exposure contributes to increasing rates of birth defects, fertility problems, greater susceptibility to disease, diminished intelligence, and certain cancers. Twelve POPs have been identified by the United Nations Environment Programme as requiring urgent regulatory attention. They include the pesticides aldrin, chlordane, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, mirex, and toxaphene. Of the remaining three POPs, polychlorinated biphenyls are industrial products (used in electrical transformers), and dioxins and furans are unintentional by-products of industrial processes.

Aldrin↗
PubMed1999

Turning over a new leaf. Tobacco.

Anticipating a diminishing market for cigarettes and other tobacco products in the future, researchers around the country are studying alternative uses for tobacco plants. The most promising field of research for tobacco involves the genetic engineering of tobacco plants to produce various substances such as industrial chemicals, pharmaceuticals, and consumer product ingredients. Tobacco has been called the "fruit fly of the plant kingdom" because of the ease with which it can be genetically engineered. There are countless possibilities for the use of tobacco, but current efforts are concentrating on engineering tobacco to produce vaccines, human enzymes, and plastics. Tobacco researchers have been successful in expressing bovine lysozyme, an enzyme with antibacterial properties, and insulin.

Biotechnology↗
PubMed1999

Testing their metal.

Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human and animal carcinogens, while many others are suspected to play a role in cancer. Little is known, however, about the mechanisms by which metals cause cancer.

Arsenic Poisoning↗
PubMed1999

Floorward thinking.

From its creation to its disposal, there are environmental and health problems associated with polyvinyl chloride (vinyl), the major component of vinyl flooring. The production of vinyl creates toxic waste that must be dumped or incinerated. Because very little vinyl is recycled, the waste material must also be landfilled or burned. Furthermore, the heavy chlorine content of these materials result in the release of dioxins into the environment. A new flooring alternative to vinyl recently entered the market. Stratica, manufactured by Amtico Company Limited based in Coventry, United Kingdom, is made from polymer resins and offers the durability of vinyl without the environmental impact.

Floors and Floorcoverings↗
PubMed1998

20 years of toxicology.

With over 80,000 chemicals being used in commerce worldwide, it is important to identify the human health effects of these chemicals and the levels of exposure at which they are harmful to humans. In order to address this need, the National Toxicology Program (NTP) was established in 1978; since then, the NTP has become the world's leader in designing, conducting, and interpreting various types of toxicity assays.

Animals↗
PubMed1998

Between a rock and a healthy place.

The Federal Mine Safety and Health Act of 1977 consolidated all federal health and safety regulations of the mining industry-coal as well as noncoal mining-under a single mandate administered by the Mine Safety and Health Administration (MSHA). Today, the agency is striving to reduce the environmental health risks associated with mining.

Air Pollutants, Occupational↗
PubMed1996

The locus of age-related movement slowing: sensory processing in continuous goal-directed aiming.

Prolonged movement times in elderly persons have been well documented; however, the locus of this slowing is uncertain. Kinematic analysis of discrete aiming has revealed deficits primarily in the target approach phase, suggesting inefficient feedback processing. This study investigated age-related movement slowing in a continuous aiming task, for which movements are mediated by feedforward and on-line sensory processes. Two-dimensional video-recordings were made of young and elderly adults performing reciprocal tapping using the right and left hands under three different accuracy conditions. The elderly subjects exhibited more discrete adjustments in the trajectories coupled with longer times in this period. Further, the elderly spent more time reversing direction between target hits, especially in the high accuracy condition. Longer time on target was seen in the left-hand performance of the elderly. Results suggest that the locus of age-related slowing in the performance of continuous aiming may reflect a greater dependence on slower feedback processes instead of rapid, on-line, and feedforward sensory processes. Age-related differences in hand performance may provide further insight into central processing deficits.

Adult↗
PubMed1994

Parents' and children's ratings of sleep behavior, excitement, and tiredness: a 10-week longitudinal study.

In a 10-week longitudinal study, 29 parents and their children kept daily records of the children's sleep behaviors, excitement levels, and tiredness levels. Although the hypothesized increase in sleep behaviors such as sleepwalking and restlessness during the week of Christmas did not occur, children rated as more excitable by their parents and themselves exhibited a higher frequency of sleep behaviors. Positive associations were also found between averaged tiredness ratings and sleep scores. The results support previous findings of an association between arousal characteristics of children and their sleep behavior. Moderate validity coefficients were obtained for parents' and children's ratings of excitement, tiredness, and nocturnal waking.

Arousal↗