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Biomedical subjects

B E Glahn

Publications and source records attributed to B E Glahn.

At least 19 recordsLinked to original sources
PubMed1989

Biocompatibility of urinary catheters. Effect on complement activation.

The ability of 2 brands of urinary catheters to activate the complement system in vitro as a marker of biocompatibility was investigated. Pieces of a silicone/latex catheter and an all-silicone catheter were incubated in human serum. Complement activation was tested in 2 enzyme immunoassays, one evaluating C3 activation and the other the terminal complement complex (TCC) formation. The silicone/latex catheter caused considerably more complement activation in both assays than did the all-silicone one. The findings are in agreement with previous results of tissue toxicity tests. The methods presented may prove valuable for the practical purpose of testing the biocompatibility of urinary catheters.

Biocompatible Materials↗
PubMed1988

Influence of drainage conditions on mucosal bladder damage by indwelling catheters. I. Pressure study.

Clinical observations suggest the occurrence of a hydro-dynamically generated negative pressure wave in termination of bladder evacuation in patients with an intermittently clamped indwelling catheter. This in-vitro study confirmed the assumption. At circumstances like those of a bedridden person with a conventional urinary drainage system the transitory suction at the site of the catheter eyes reaches negative peak pressures of about 150-180 cm of water when catheters on a latex base are used and about 300-350 cm by catheters of 100% silicone, which is a less compliant (elastic) material. Catheters, drainage tubes and the combined function were analyzed regarding factors influencing this hydro-dynamical phenomenon, which may occur in some situations of straight drainage too. Clinical aspects are discussed. A noxious effect on the bladder mucosa is demonstrated in a subsequent study. It is concluded that the basal hydro-physical laws involved in bladder drainage by indwelling catheter need more attention.

Animals↗
PubMed1988

Influence of drainage conditions on mucosal bladder damage by indwelling catheters. II. Histological study.

A previous study demonstrated a strong but short-lasting suction through the catheter eyes by a hydro-dynamically generated negative pressure fluctuation terminating bladder evacuation in some frequently occurring circumstances of indwelling catheter drainage. This report regards the biological effect. Fifteen successive evacuations on such drainage conditions in each of 4 anesthetized pigs were followed by cystectomy and histological examination. All bladders presented small swollen areas, histologically showing localized mucosal elevations dominated by edema of lamina propria and submucosa, occasionally with urothelial thinning or defects. Drainage with suction prevented in 3 animals caused normal bladders. The changes were similar to those following hydro-statical suction and much like those of the "polypoid cystitis" so commonly occurring with indwelling catheters. This suggests both types of suction by ordinary drainage as a major pathogenetic factor in the latter condition. The clinical significance and the occurrence during regimes of straight drainage or intermittent clamping are discussed.

Animals↗
PubMed1981

[Aids in urinary incontinence].

A broad variety of incontinence aids should be available as the needs of the individual patient are different. The various major types of aids are described. The correct choice of aids for any patient depends on a combination of factors: aid, patient factors, and environment. Thorough knowledge of the various aids, their use, advantages, and limitations is needed. A well-organized aid-distribution centre makes an acceptable cost/benefit balance possible.

Catheters, Indwelling↗
PubMed1979

Giggle incontinence (enuresis risoria). A study and an aetiological hypothesis.

Questionnaires answered by 99 student nurses concerning bladder responses to laughter showed that roughly 25% had experienced such reactions at some time in their lives and about 10% could still register such phenomena at the end of their second decade. Giggle incontinence is not a condition confined to an "all or nothing" response of complete micturition. The evidence seems to indicate that the condition is due to some inborn and quite ordinary trigger mechanism exposed by physiological variations in sensitivity or specific control.

Adolescent↗