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Biomedical subjects

B E Jensen

Publications and source records attributed to B E Jensen.

9 recordsLinked to original sources

Adherence in the training levels comparison trial.

In the Training Levels Comparison Trial, 197 male coronary heart disease patients were randomized to low or high intensity training with target heart rates, which corresponded to 50% and 85% of the VO2max achieved on the previous exercise test, respectively. Patients were to exercise at their assigned intensity level at three 1-h long supervised sessions per week for 2 yr. This paper reports on two components of adherence: attendance at exercise sessions and achievement of heart rates in the target range. During the first year of training, the average percent of exercise sessions attended (mean +/- SE) for the low intensity group (64.0 +/- 2.5%) was significantly higher than for the high intensity group (55.5% +/- 2.7%). At the end of 1 yr of training, 54% and 37% of the low and high intensity patients, respectively, achieved heart rates within 5 beats.min-1 of their target heart rates. Although the low intensity program was preferable to achieve maximum attendance, attenders on the high intensity program achieved higher heart rates. These results suggest that to maximize the achieved heart rate, it would be optimal to motivate a cardiac rehabilitation patient to train at the high intensity level for a prolonged period of time.

Adult↗

Exercise testing and training in physically disabled men with clinical evidence of coronary artery disease.

A prospective, randomized, controlled clinical trial in patients with coronary artery disease (CAD) and a concurrent physical disability evaluated the effects of a home exercise training program on cardiovascular function and blood lipids. Eighty-eight men between the ages of 42 and 72 years (mean 62) with documented CAD and a physical disability with functional use of > or = 2 extremities including 1 arm were randomized to either a 6-month home exercise training program using wheelchair ergometry or to a control group that received usual and customary care. Both groups received dietary instructions and were requested to follow a fat-controlled diet. Exercise test variables with echocardiography and blood lipids were measured at baseline and at 6 months. The home exercise training group significantly improved both peak exercise left ventricular ejection fraction (p = 0.007) and fractional shortening (p = 0.01) between baseline to 6 months, whereas the control group showed no significant changes. Exercise training effects of decreased resting heart rate (p = 0.03) and decreased peak rate pressure product (p = 0.03) were also found in the treatment group. No exercise-related cardiac complications occurred. Both groups significantly (p < or = 0.01) increased high-density lipoprotein cholesterol levels. These results indicate that physically disabled men with CAD can safely participate in a home exercise training program which may result in intrinsic cardiac benefits. The metabolic cost of activities of daily living imposed on this disabled population may also have a positive effect on high-density lipoprotein cholesterol levels.

Adult↗

Design of the training levels comparison trial.

The Training Levels Comparison (TLC) trial was a grant-supported, multicenter, randomized, controlled clinical trial designed to determine whether cardiac rehabilitation patients would benefit from supervised exercise for a prolonged period (2 years) and whether subjecting patients to a more vigorous exercise program than currently recommended would provide additional cardiac benefit. If high-intensity exercise does not enhance the cardiac benefit, then physical activity should be limited to low-intensity levels that are safer, easier to implement and more adaptable to a greater number of patients. Patients were randomly assigned to either a low-intensity or high-intensity training program. All patients were to attend three 1-hour supervised exercise sessions per week for a period of 2 years. Attendance at exercise sessions and adherence to assigned treatments were monitored throughout the study. Patients were evaluated for outcome measures at 3, 6, 12, and 24 months. This paper reports the study design and methodology for the TLC trial, and should be useful in providing methodologies to facilitate comparison of data from other studies with different levels of exercise as an intervention.

Adult↗

Antibodies to pigeon antigens in pigeon breeders. Detection of antibodies by an enzyme-linked immunosorbent assay.

Antibodies to whole pigeon serum (PS) and pigeon dropping extract (PDE) were investigated in pigeon breeders and controls by an enzyme-linked immunosorbent assay (ELISA). The optimal antigen concentration was in the range of 3-30 microgram protein/ml for both PS and PDE. PDE antibody titres greater than or equal to 10240 were found in three (75%) of four patients with pigeon breeders' disease (PBD) and in 19 (13.6%) of 140 other pigeon breeders (P = 0.011). PS antibody titres greater than or equal to 10240 occurred in all four (100%) PBD patients and in only seven (5.0%) of 140 other breeders (P = 0.0002). In 85 blood donors antibodies in low titres against PS and PDE occurred in 4.7% and 7.1%, respectively. By immunodiffusion three or more precipitin lines were found more often in PBD patients than in other breeders (P = 0.0006), and the highest ELISA antibody titres occurred in patients with precipitating antibodies. No correlation between P blood group phenotypes or anti-P1 antibodies and respiratory symptoms or antibodies to pigeon antigens could be demonstrated.

Adolescent↗

Effects of precision of knowledge of results on performance of a gross motor coincidence-anticipation task.

The purpose of the investigation was to determine the effects from three knowledge of results (KR) precision levels (qualitative; 0.10 sec, 0.001 sec) on the performance of a gross motor coincidence-anticipation task where subjects performed with visual and other sense modality input. Other variables included in the analysis were sex, movement distance, and practice over three blocks of trials. Absolute error (AE), constant error (CE), variable error (VE), and E scores (E) of the subjects from two experiments (N = 90; N = 54) were analyzed with 3 x 2 x 2 x 3 ANOVAs with repeated measures on the last two factors (feedback, sex, movement distance, blocks). Consistent finding from both experiments indicated that, for this gross motor coincidence-anticipation task, the subjects performed as accurately and as consistently when they received qualitative KR as when, in addition, they received more precise KR. Subjects performed with less error on the short as opposed to the long term distance pattern. Males performed with less error on the long movement pattern than females in Experiment 1; however, the only sex difference noted in Experiment 2, when the movement distances were shortened, was that males had a more on-time CE mean score.

Journal Article↗

Training level comparison study. Effect of high and low intensity exercise on ventilatory threshold in men with coronary artery disease.

PURPOSE: To determine whether exercise at low intensity (LO; 50% of peak VO2) or high intensity (HI; 85% of peak VO2) results in improvement of the ventilatory threshold (VT), 186 men with coronary artery disease (CAD) were enrolled in an exercise study for 1 year. METHODS: A symptom-limited exercise test was performed at baseline and the heart rate corresponding to 50% and 85% of peak VO2 was determined. Subjects were randomized to LO or HI intensity exercise. Exercise sessions included 45 minutes of walking/jogging and/or stationary cycling at the appropriate target heart rate and were conducted 3 days per week. The exercise test was repeated at 3 and 6 months. Target heart rates were revised to adjust for training. RESULTS: Both LO and HI resulted in improved VO2 at VT and peak. However, HI resulted in greater improvement than LO. CONCLUSION: Among this population, both HI and LO improve the VO2 at VT and peak, but the improvement is greater with HI. The VT can be a useful adjunct to heart rate and peak oxygen uptake when prescribing exercise.

Anaerobic Threshold↗