New product development: can technique substitute for technology?
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Community Participation↗
Biomedical subjects
B E Meyers
Publications and source records attributed to B E Meyers.
The effect of selected amino acids on gelatin-induced inflammation in adult male mice.
Several studies have indicated to us that certain amino acids may exhibit antiinflammatory activity. In the present study we attempted to evaluate the inhibitory effect of various amino acids on gelatin-induced abdominal inflammation in mice using peritoneal fluid cytology as the diagnostic tool. The L-amino acids tested were tryptophan, phenylalanine, alanine, cystine, hydroxyproline, tyrosine, citrulline, leucine, and valine. Hydrocortisone was used as an antiphlogistic steroid control. Tryptophan, phenylalanine, alanine, cystine, hydroxyproline, and tyrosine all significantly decreased the inflammation. Citrulline and valine, however, both exhibited strong antiiflammatory responses. Based on these results, three related dipeptides were also screened: L-valy-L-alanine, L-valyl-L-tryptophan, and L-tyrosl-L-valine. Valyl alanine was found to produce a strong antiinflammatory effect. In a final test, the combination of the steroid, hydrocortisone, and the amino acid, cystine, was screened for a synergistic effect. The combined treatment inhibited the gelatin-induced inflammation more than either the amino acid or the steroid administered alone.
Amino Acids↗
Chronic occlusion of the rabbit Fallopian tube with silicone polymer.
Investigators have previously reported good retention, antifertility efficacy, and good retrievability with no adverse tissue reactions in rabbit oviducts occluded with silicone rubber for 55 days. The present study attempts to determine the long-term effects of this silicone polymer system installed into the oviducts of 12 New Zealand White rabbits for 7 months. 9 rabbits had both oviducts occluded while 3 had only one oviduct treated. All animals were visualized by X-rays and were mated an average of six times over the experimental period. Oviduct tissue was examined with light and scanning electron microscopy. There was no evidence of inflammation, distortion, or tissue irritation. Good retention and antifertility efficacy were exhibited.
Animals↗
The peritoneal fluid cytology of adult female dogs.
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Animals↗