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Biomedical subjects

B E Michael

Publications and source records attributed to B E Michael.

4 recordsLinked to original sources

Psychosocial issues in childhood cancer. An ecological framework for research.

A number of psychosocial issues are evolving as childhood cancer becomes a chronic rather than a fatal condition. These include issues associated with extended hospitalization and social isolation, as well as long-term adjustment to survival that may involve recurrence of disease. Primary emphasis in current research and intervention is placed on how children and their families adapt to long-term survival. This article reviews the scope and limitations of previous research in this area, which focuses on the individual with little reference to the family, school, or social networks or to the interactions occurring among these arenas. An ecological model is suggested as the most useful perspective for enhancing our understanding of the impact of childhood cancer on the child, family, and community. Much of what is already known about how cancer and its treatment affect children and families is consistent with the propositions of an ecological model. The transactional, reciprocal, and interdependent nature of coping behaviors within a family system is perhaps the most obvious indicant of the need for multiple perspectives for understanding how families respond to the pressures of a chronic, but possibly life-threatening, illness. An ecological approach is timely, therefore, in that there is a need for psychological research and intervention directed beyond the immediate context of treatment to extended levels of social interaction and social systems.

Adaptation, Psychological↗

Medullary thyroid carcinoma with radioiodide transport. Effects of iodine-131 therapy and lithium administration.

A 37-year-old woman presented with a neck mass that proved to be medullary thyroid carcinoma by histologic and immunoperoxidase examinations. Serum calcitonin values were greatly elevated (over 100,000 pg/ml). There were widespread metastases in bone and liver. As the peripheral lesions showed only slight response to chemotherapy and local radiation therapy, potential use of radioiodine was studied. The bone lesions showed uptake of both Tc-99m MDP and radioiodide (I-131). Metastatic lesions were similar to the primary tumor in terms of histology, presence of calcitonin, and absence of thyroglobulin. Hence, the patient had a medullary thyroid carcinoma that took up radioiodide in its metastases. Two large oral doses of radioiodide (over 100 mCi each) did not significantly alter the serum calcitonin values, although there was a slight response in the activity of bone lesions. The whole body turnover of radioiodide was rapid (T 1/2 = 0.7 days). Upon oral administration of lithium carbonate, whole-body radioiodide turnover slowed slightly (T 1/2 = 1 day). If this effect were reflected in greater tumor retention of radioiodide (slower release), then agents that block radioiodide egress might have a role to play in therapy.

Adult↗

Visual masking with presentations in same and opposite visual fields: evidence for contralateral masking.

Three experiments were conducted in a preliminary attempt to study the effects of presentations of an informational target stimulus to the right or left visual fields when the target was either preceded or followed by a noninformational masking stimulus and when the mask was presented to the same or opposite visual field of the target. Results indicated that masking was more effective in the same than in the opposite visual field but that masking of the opposite visual field was feasible for both forward and backward masking. Laterality effects were also found for forward and backward masking, with a modest advantage of the right visual field (left hemisphere) in both cases. Limitations of the data and directions for future research were discussed.

Discrimination Learning↗