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Biomedical subjects

B E Movshev

Publications and source records attributed to B E Movshev.

At least 19 recordsLinked to original sources
PubMed1994

[Therapeutic plasmapheresis in immune complex diseases].

We studied the dependence of the plasma protein and volume on the exfusion volume, type and composition of the substitution solution in 140 plasmapheresis procedures given to patients with immune thrombocytopenic purpura and bronchial asthma. The change of blood protein system corresponded to the procedure regime. The procedure does not entail adverse reactions if it removes up to 30% of the plasma circulating volume (replacement with salt solution), 50% of the plasma circulating volume (replacement with dextran solution) or 95% of that with replacement with albumin. We have tested 3 simple mathematic models for postplasmapheresis proteinemia and recommend the regression equation Ct = a0 + a1.Co as the most adequate model.

Algorithms↗
PubMed1992

[Blood protein-volume indicators in massive plasmapheresis].

Hyperproteinemia values were studied before and after plasmapheresis in 32 rheumatoid arthritis patients with no manifest circulatory disorders. Mathematical patterns enabling prediction of changes in protein concentration depending on the volume of removed plasma and the type of substitution have been proposed for 3 alternative regimens of the procedure (removal of 0.5 or 1.0 volume of the circulating plasma, and substitution for rheopolyglucin or albumin). The data of independent "examining" sampling (15 patients) have proved adequacy of the linear regression patterns.

Arthritis, Rheumatoid↗
PubMed1992

[Comparative assessment of various programs of plasmapheresis in the combined treatment of patients with rheumatoid arthritis].

Therapeutic efficacy of various plasmapheresis (PA) programmes was comparatively studied in 92 patients with rheumatoid arthritis. PA performed as a placebo (the control group) confirmed the efficacy of PA in the patients with rheumatoid arthritis. The choice of a particular regimen of the procedure depended on the health status of the patient. The programme of PA with the elimination of one volume of the circulating plasma (VCP) turned to be the most effective in the patients with highly active course of the disease while the procedures with the elimination of 1/2 and 1/4 VCP should be used in those with moderate or minimal activity of the disease. The assessment of the therapeutic response should be based on the clinical data, ESR and the contents of circulating immune complexes--the most dynamic laboratory tests.

Adult↗
PubMed1991

[Colloid osmotic pressure and the total protein level in assessing the safety of therapeutic plasmapheresis].

In 117 plasmapheresis procedures provided to rheumatic arthritis patients, the authors studied the changes in colloid osmotic pressure (COP), proteinemia and systemic arterial pressure depending on the plasma volume removed and on the type and volume of the substituting solution. Plasmapheresis carried out in 3 alternative regimens was not accompanied by dangerous exchange in the protein system. The substitution of the removed plasma by albumin and rheopolyglukin ensures an effective maintenance of COP just after the procedure. Since the elimination of polyglucin from the vascular system proceeds quicker than making up for protein deficiency, there is a potential danger of inadequate reduction of COP several hours after the procedure. Simple mathematic models have been proposed for the description of the COP level and proteinemia after plasmapheresis, which can be used for prognosis.

Adult↗
PubMed1989

[The protein-blood volume indices during moderate plasmapheresis].

Quantitative characteristics of changes in the volume of circulating plasma and the amount of circulating protein were studied in rheumatoid arthritis patients before and after plasmapheresis of moderate intensity. Basing on the comparison of the precalculated and estimated parameters the authors have suggested 4 mathematical models equally describing the protein-volemic relationships in the body. Satisfactory correlation has been recorded between the estimated and precalculated values of protein concentration in the plasma after plasmapheresis that enables data collection in a short cut program.

Adult↗
PubMed1989

[Macroproteinemia and the prognostic assessment of blood loss].

The dependence of blood loss quantitative indices (duration, number and volume of exfusions) on the initial state of the blood protein system was studied in experiments with dogs. The true correlation was found between the macroprotein contents in plasma and the duration of the arterial pressure compensation phase at the level of 5.3 kPa (40 mm Hg). Hypermacroproteinemia is evident of low organism stability (resistance) and is an unfavourable prognostic characteristic in experimental blood loss.

Animals↗
PubMed1987

[Mathematical modeling of protein loss during prolonged blood loss].

The dependence of protein losses on the initial condition and experimental conditions were studied in dogs on a model of repeated bloodletting. Various animals have an intensive increase in this value in the beginning and a gradual decrease at later stages. Four mathematical models adequately describing changes in losses depending on the number of bloodlettings and duration of arterial pressure compensation phase have been suggested.

Animals↗
PubMed1985

[Hypotensive activity of the plasma proteins in a normovolemic blood exchange transfusion].

The effect of post-hemotransfusion protein fractions on blood pressure, microcirculation and physiologically active substances has been studied in stimulated blood replacement by homologous animal blood. The in vivo and in vitro experiments have revealed that subfraction of hemotransfusion plasma macromolecular proteins has a prominent antihypertensive effect, leading to blood flow slowing in the microvascular bed. Hemotransfusion plasma proteins possess high serotonin-releasing activity. The involvement of blood proteins and physiologically active substances into the generation of the recepient's response to homologous blood transfusion from several donors and its role in the genesis of post-transfusion complications are discussed.

Animals↗
PubMed1984

[Biotesting of a burn toxin on mice with reticuloendothelial system block].

Experiments on mice with reticuloendothelial system blockade were made to assay the toxic properties of the preparations obtained from the skin of burn and normal rats. As regards the activity level the preparations can be classified with either highly toxic or little toxic. Analysis of the dose-response dependence indicates that toxicity of the extracts is accounted for by at least two different toxins.

Animals↗
PubMed1982

[Therapeutic effectiveness of gamma-globulin on experimental burns].

Experiments on rabbits were made to examine excretory-absorption liver function and the blood kallikrein-kinin system after thermal burn and treatment with gamma-globulin immune to burn skin toxin. Immunotherapy leads to a more rapid and effective recovery of the functional indicators in the burnt animals than in burns without or with the treatment by nonimmune preparations. It was demonstrated that specific detoxification plays an important role in multiple modality treatment of burn disease.

Animals↗