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Biomedical subjects

B Ecanow

Publications and source records attributed to B Ecanow.

At least 19 recordsLinked to original sources
PubMed1979

The role of inert particles in malignant transformations: a hypothesis of carcinogenesis.

Controlled cellular growth exists in an aqueous matrix that undergoes a spectrum of reversible solvent and structural conformational changes. In contrast, malignant tumor formation occurs in an irreversible nonpolar aqueous matrix (coacervate); that is, in a physicochemical sense uncontrollable cell growth exists in a hydrocarbon-like milieu. It is proposed that foreign isoluble particles which locate on cellular surfaces can induce such coacervate structuring. Resultant formation of abnormal film matrices could initiate pathological transformations in the morphology, metabolism, and replication of the affected cells. In short, this abnormal matrix formation may be a critical factor in the development of malignancies, both avascular and vascular stages. It would follow that drugs or other agents capable of disrupting coacervated water matrices could be effective in the treatment of cancer. Experimental studies in our laboratory and clinical data from other sources support this hypothesis.

Adsorption↗
PubMed1977

Water as a nonpolar partition medium.

Coacervates have been suggested as models for cytoplasm since cytoplasm is also essentially an aqueous phase of water-protein-colloid complexes. This study on partition coefficient properties made use of coacervate phases as the nonpolar phases in equilibrium with polar water phases. The partition coefficients of four barbiturates were obtained, and their values correlated with those reported in the literature for systems using organic solvents as the nonpolar medium. These values also correlated with reported values for the absorption ranking of the barbiturates in the rat colon. The partition coefficients of theobromine and theophylline in gelatin-benzalkonium chloride coacervate systems were also found to correlate with the partition values reported in the literature for heptane-water and chloroform-water systems. Is is suggested that coacervate systems form a more realistic model for studying and predicting the absorption characteristics of drugs than do conventional organic solvent-water systems.

Animals↗
PubMed1976

Oxygen solubilization by lung surfactant.

To illustrate the concept of solubilization as a possible mode of gas transport in biological systems, dog lung surfactants in varying concentrations were tested for their ability to solubilize oxygen. The degree of gas solubilization was determined by GC, using a modified tonometer as an absorption chamber. The concentration of surfactant was found to be an essential factor for gas solubilization. Surfactant concentration above the CMC yielded anomalously high gas absorption. Solubilization of the gas is thought to occur by a partitioning effect into the interior of surfactant micelles.

Animals↗
PubMed1976

Filtration rates of pharmaceutical suspension systems.

This study was undertaken to find it a correlation exists between the filtration rate and the Hu/Ho ratio. For this purpose, flocculated and coagulated structures of sulfamerazine were used. Suspension settling profiles and filtration rates, using additives and additive-free sulfamerazine suspensions, were studied. A straight-line correlation was found. Effects of filter bed parameters on refiltration rates were studied, and a relationship was found by the use of the Kozeny-Carman equation. A straight-line relationship existed between the H1/Ho ratio and the filtration rate exhibited by the different suspension aggregates.

Aluminum↗