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Biomedical subjects

B Eichel

Publications and source records attributed to B Eichel.

12 recordsLinked to original sources
PubMed1991

Unaltered pharmacokinetics after the administration of high-dose etoposide without prior dilution.

The pharmacokinetics of etoposide following a new method of administration was determined. Undiluted etoposide was given at a dose of 30 mg/kg as part an intensified conditioning regimen prior to bone marrow transplantation. A terminal half-life of 3.4 +/- 0.7 h and a volume of distribution of 15.4 +/- 9.6 l were found (n = 8); the AUC was 764 +/- 302 micrograms h ml-1. As compared with those obtained in other pharmacokinetic studies using etoposide diluted in normal saline, our data reflect full systemic bioavailability and unaltered pharmacokinetics. The application of undiluted etoposide makes the therapy easier and less time-consuming and avoids a high fluid volume and a high saline load.

Acute Disease↗
PubMed1991

Ethmoid surgery complications and their avoidance.

The purpose of this report is to review the complications that two experienced operators have encountered during the past 20 years. The techniques employed by the authors are similar. Three thousand intranasal non-endoscopic procedures accumulated between the co-authors were further evaluated to explain why complications could occur. There were five dural injuries in this series that were managed conservatively. Periorbital ecchymoses were seen in 9% of the cases with no permanent adverse sequelae. Approximately 0.5% of the patients had postoperative bleeding. Conclusions that the authors reached were as follows. 1) A complication as a result of ethmoid sinus surgery can occur with any technique and in the hands of any surgeon. 2) Training and experience plus knowledge of the ethmoid anatomy may help reduce the absolute number of complications. 3) Early recognition of a complication and its appropriate management can help decrease the relative severity of the complication. 4) The surgeon should terminate a procedure when visualization and localization are compromised.

Ethmoid Sinus↗
PubMed1985

Ethmoiditis. Pathophysiology and medical management.

The ethmoid labyrinth occupies the key anatomic position of the entire sinus complex. A series of cases is presented to illustrate radiographically the importance of the ethmoid sinus in various histopathologic states and the need for therapy to be directed to this location.

Adult↗
PubMed1969

Tobacco smoke toxicity: loss of human oral leukocyte function and fluid-cell metabolism.

The human mouth has been utilized as a new and significant in vivo open bioassay system for tracing undesirable substances present in tobacco smoke, in an exact milieu where the smoking "problem" begins and must be dealt with directly. The associated in vitro closed test systems described herein have provided new, sensitive bioassays that help to explain the in vivo effects.

Biological Assay↗
PubMedDate not supplied

Comparison of trimethoprim-sulfamethoxazole with ampicillin in acute infectious exacerbations of chronic bronchitis: a double-blind crossover study.

Two separate acute bacterial exacerbations of chronic bronchitis or chronic asthmatic bronchitis were treated in 20 patients in a double-blind crossover study. One course of treatment consisted of 320 mg of trimethoprim (TMP) plus, 1,600 mg of sulfamethoxazole (SMZ) daily and the other of 2 g of ampicillin daily; each drug was given for 14 days. Patients were observed initially, twice a week during therapy, and weekly after therapy. Observations that were recorded included graded chest symptoms and physical findings, vital signs, pulmonary function, hematologic parameters, and objective sputum measurements (daily volume, purulence, differential quantitative cytology, quantitative bacterial counts, physical properties, levels of lactate dehydrogenase with its isoenzymes, levels of myeloperoxidase, and presence of deoxyribonucleic acid fibers). Both antibiotic regimens were effective in resolving these acute bacterial exacerbations. Paired t-test analysis revealed few and minor differences between TMP-SMZ and ampicillin during therapy, although three patients did not complete TMP-SMZ therapy because of adverse reactions. However, the period between the two bacterial exacerbations was significantly longer after ampicillin therapy. Innovative in this investigation are the study design and the objective quantitative measurements of inflammatory response and bacterial populations in sputum.

Acute Disease↗