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Biomedical subjects

B Emeryk

Publications and source records attributed to B Emeryk.

At least 19 recordsLinked to original sources
PubMed1990

[Reactivity of periodontal vessels in children with insulin-dependent diabetes].

The morphological changes of capillaries and small vessels in diabetes are preceded by functional disturbances. The purpose of the work was assessment of the reactivity of parodontal vessels in children with insulin-dependent diabetes. The study was done in 50 children with this diabetes aged 7 to 17 years, and 45 healthy controls (without parodontal changes). The photoplethysmographic method was used. Nitroglycerine test of Böhme was carried out estimating the pattern of the so called inclination time before and after sublingual nitroglycerine administration. The capillaries of the diabetic children reacted more strongly to nitroglycerin than those of controls. It is concluded that children with diabetes of recent onset have functional vascular disturbances in the parodontium. Photoplethysmography is a simple non-invasive method useful in the assessment of early vascular disturbances in the parodontium of children.

Adolescent↗
PubMed1990

Pseudoselectivity of the neuromuscular block in ocular myasthenia: a SFEMG study.

The patients with pure ocular myasthenia presenting no signs of neuromuscular transmission defect on classical supramaximal repetitive stimulation were studied using SFMG method. Only those patients were selected to the study in whom the diagnosis of the ocular myasthenia was confirmed by the clinical criteria arranged so as to exclude ophthalmoplegia of the other nature. The series comprises 20 patients in whom the results of the supramaximal repetitive stimulation with the recording from the proximal muscles and with the evaluation of posttetanic phenomena were normal. SFEMG examination was performed in the clinically intact EDC muscle and in 17 patients an elongated jitter, sometimes with blocking was found. Among those three patients with normal results two were in full clinical remission, so there was only one patient presenting the symptoms of ocular myasthenia in whom the neuromuscular transmission defect was absent in the EDC. The results justify an admission that the neuromuscular block in ocular myasthenia is only apparently selective; in fact it concerns all the muscles with a different severity and may be detected if properly sensitive diagnostic methods are applied.

Adolescent↗
PubMed1990

Disintegration of the motor unit in post-polio syndrome. Part I. Electrophysiological findings in patients after poliomyelitis.

CN EMG and SF EMG were performed in 12 patients many years after acute poliomyelitis, without symptoms of post-polio syndrome. In 19 muscles with clinical symptoms and in 11 clinically normal muscles chronic neurogenic changes of a similar degree were observed. Fibre density was increased in both groups of muscles. In muscles with clinical symptoms complexes of single fibres with increased jitter and blocking were more frequent than in muscles without clinical manifestations. It seems that the reinnervation after acute polio is a continuing process and thus complete stabilization and integration of the motor unit cannot be achieved.

Action Potentials↗
PubMed1990

Disintegration of the motor unit in post-polio syndrome. Part II. Electrophysiological findings in patients with post-polio syndrome.

The aim of the study is to investigate the motor unit abnormalities in late postpolio muscular atrophy (PPMA) as compared to those found in patients who had polio 20-30 years prior to examination without any new clinical signs. The quantitative concentric needle EMG and a single fiber EMG techniques were employed. Spontaneous activity, the parameters of individual motor units potentials (MUP), number of complex potentials and their stability, jitter and blocking as well as fiber density (FD) have been evaluated. In PPMA patients (5 subjects) we found in newly weakened muscles: spontaneous activity, high percentage of complex potentials, increased jitter, increased FD. The EMG findings in muscles previously affected but without any signs of progression have been similar. In the patients with stable nonprogressing postpolio muscle atrophy (12) all MUP-s parameters indicated changes similar to PPMA but less marked in initially affected muscle with complete or incomplete recovery as well as sometimes in initially clinically unaffected muscles. These findings suggest that the signs of ongoing reinnervation processes persist many years after polio and that PPMA occurring later in life represents disintegration of the previously reinnervated motor units. It is still unclear whether this disintegration depends on decompensation by different factors of fully reinnervated motor units or whether most of the motor units after polio never regained a stable reinnervation.

Adult↗
PubMed1985

Do true remissions in myasthenia really exist? An electrophysiological study.

To answer the question whether true remissions in myasthenia gravis occurred, 20 patients were studied with a history of evident, typical myasthenia but in full clinical remission. Two control groups served as a comparison: one of 10 healthy volunteers and the other of 10 patients with generalized, presently active myasthenia. In 17 of the 20 patients in remission single-fibre EMG (SFEMG) abnormalities were found, indicating some subclinical disturbances of neuromuscular transmission (in 3 cases the results were overtly pathological, in 11 cases moderately pathological, and in 3 cases slightly pathological). The abnormalities found in the remission group were much less distinct than those in the group with clinically symptomatic myasthenia. A case illustrates these findings: a man in full remission following thymoma extirpation in whom the SFEMG revealed subclinical disturbances of the neuromuscular transmission. Three weeks later a full clinical relapse occurred. The results obtained suggest that in the majority of patients the remissions are only apparently complete. A pathological jitter in a patient in remission calls for special attention: the patient must be spared any immunological stimuli such as vaccination, injections of sera, infections etc.; no drugs can be given which may increase the neuromuscular block; an immunosuppressive course of treatment should be considered; prognosis should be reconsidered.

Adolescent↗
PubMed1982

[Evaluation of treatment of myasthenia with thymectomy (author's transl)].

The paper describes the effectiveness of treatment of myasthenia with thymectomy in 136 patients operated on, observed in hospital and 107 examined by questionnaire on late results after 10 years. Exclusive of myasthenia with thymoma, cures were obtained in 26.4%, marked improvement in 19.6%, moderate improvement in 21.4%, improved motor strength in 27.1%, and deterioration was observed in 3.8%. The assessment was based mainly on the amount of cholinergic drugs taken. Early mortality rate was 2,4%, and late mortality 1,9%. Relation of postoperative complications/respiratory and crisis of both kinds to mortality and intraoperative pleural injury also surgical approach and anatomic variants of the thymus were discussed. An influence of the number of proliferating centers on prognosis in myasthenia after thymectomy was nor demonstrated. Thymectomy in a generally accepted and most effective method of treatment in myasthenia.

Adolescent↗
PubMed1979

Nerve conduction in the Guillain-Barré-Strohl syndrome.

Fifty cases of the Guillain-Barré-Strohl syndrome were investigated clinically and electrophysiologically--20 in the acute phase, and 30, as a matter of followup, many years after. The sural nerve was biopsied in six cases. There was no evident correlation between clinical symptoms and slowing of motor and sensory conduction. Nerve conduction velocity became slower after the beginning of clinical improvement. The electrophysiological abnormalities concerned both sensory and motor fibers despite the frequent absence of clinical sensory manifestations. The so-called long nerves were involved earlier and more markedly than the so-called short nerves. Conduction velocity and distal latency were equally affected. A slight electrophysiological defect was noticeable even many years after the acute phase of the syndrome, in completely symptoms free patients. Some correlation existed between conduction velocity changes and histological findings.

Acute Disease↗
PubMed1976

Evaluation of results of thymectomy in myasthenia gravis.

The results of thymectomy carried out in 150 cases of myasthenia gravis are discussed. In a group of 123 cases followed for 1 to 5 years after the operation, full remission was observed in 24.4% of cases, significant improvement in 36.6%, slight improvement in 24.4% and no improvement in 8.1%, while deterioration occurred in 1.6% of patients. No correlation was found between the result of the operation and the age and sex of patients, but better results were achieved in those treated surgically rather soon after the onset of symptoms. This correlation was particularly evident in the group with full remissions. The results obtained in the cases without thymic tumors were better than in the cases with tumors. No correlation was noted between the results of the operation and the histological characteristics of the thymus in the group with thymic hyperplasia and in the group with thymic atrophy. The surgically treated group (150 cases), compared with the conservatively treated group (75 cases), showed the superiority of the surgical method (lower rate of death and deterioration, higher rate of improvement and remission). In discussing the indications for surgical treatment the authors emphasize that advances in anaesthesiology in recent years have reduced the risk of operation. It is suggested that the indications for surgical treatment should be expanded and operations should be performed as early as possible after the onset of clinical manifestations without regard to the age and sex of the patient. Operation should not be considered in cases belonging to group 1, 2a (sometimes 2b) only, with duration of the disease over 8-10 years and with little or no progression of the process, if the presence of a thymic tumor has been excluded.

Adolescent↗