PubMed Health⌕ Search

Biomedical subjects

B Engels

Publications and source records attributed to B Engels.

26 records · Page 2Linked to original sources
PubMed1993

[Hypersalivation as a leading symptom of neoplastic meningiosis in highly malignant non-Hodgkin's lymphoma].

Partial remission of a centroblastic non-Hodgkin's lymphoma, clinical stage IV A, in a 79-year-old man was achieved by six courses of chemotherapy with epirubicin, cyclophosphamide and vincristine. The only residual finding was a palpable small cervical lymphoma. After a treatment pause of about 6 weeks increasing hypersalivation set in which ultimately made food intake impossible and led to a breakdown in the patient's general state. Findings in the region of the head, neck, throat and the base of the skull were unremarkable, but cerebrospinal fluid contained 1300/3 cells, almost all of them lymphoblasts. After five intrathecal injections of at first 15 mg methotrexate and 4 mg dexamethasone each, followed by five more with 40 mg cytarabine added to them, the CSF cell count became normal. At the same time salivation clearly decreased and food intake became once again possible. The patient died 5 months later from hypercalcaemia due to osseous infiltrations. Until his death there was no recurrence of the hypersalivation as the cardinal sign of meningeal carcinomatosis.

Aged↗
PubMed1990

[Pharmacokinetics and bioequivalence of two ibuprofen formulations].

In an open controlled randomized cross-over study in 16 healthy male and female volunteers the bioavailability of ibuprofen (CAS 15687-27-1) sugar-coated tablets (Dolo-Dolgit) was tested versus film-coated tablets containing ibuprofen 600 mg. As it results from the AUC evaluation, the bioavailability of both preparations is very good and almost identical. The ibuprofen concentrations achieved after administration of the test preparation, however, are significantly higher (Cmax = 52.03 micrograms/ml) than those achieved after the reference preparation showing a Cmax of 40.32 micrograms/ml. The tmax of 1.0 h is also significantly shorter than after the reference preparation (tmax = 1.5 h). The t1/2 beta after both the test and the reference preparation is within the known range, i.e. 1.8 h and 1.4 h, respectively. Even in long-term treatment with high dosages, administered 3-4 times daily, there is no accumulation of the active ingredient. Concerning the therapeutic relevance, special attention is to be given to the different time-dependent drug concentrations in the central compartment and in the target compartment. Both the higher Cmax and the shorter tmax achieved following administration of the test preparation are of therapeutic relevance.

Adult↗
PubMed1989

Percutaneous ibuprofen therapy with Trauma-Dolgit gel: bioequivalence studies.

The plasma and tissue kinetics of ibuprofen after topical application of 5% Trauma-Dolgit gel were determined in two bioequivalence studies. In eight patients, high ibuprofen concentrations, largely within the therapeutic range, were found in subcutaneous tissue, tendon, muscles and joint capsule. In plasma, however, very low concentrations (decimal exponents below the therapeutically relevant plasma ibuprofen level even after repeated application) were found in nine volunteers. Based upon the comparison of oral and topical ibuprofen forms, the test preparation was found to be bioequivalent and, from a kinetic viewpoint, safe and effective.

Administration, Cutaneous↗
PubMed1983

[Pharmacologic-toxicologic study of an ibuprofen-containing creme].

The antiphlogistic action, the percutaneous penetrability as well as the systemic and local tolerance of cremes with a different ibuprofen content after epicutaneous administration were examined in the rat, the guinea-pig and the rabbit. The antiphlogistic action was dose-dependently assessed on the carrageenin-induced edema of the rat paw and on UV-erythema in the guinea pig. The cotton-pellet test carried out on the rat evidenced only modest efficacy. The percutaneous penetration of ibuprofen after single epicutaneous application was obtained through the assessment of the active principle in the tissues and in the serum. The tests carried out for ascertaining the systemic and cutaneous tolerance did not evidence even after 3 to 4 weeks treatment with the ibuprofen creme any signs of intolerance due to the substance. In the investigation of the mucosal tolerance, the instillation of ibuprofen creme into the conjunctival sac of the rabbit led to strong yet reversible intolerance reactions in the conjunctiva and in the eyelid. Bearing on the results obtained on the whole, ibuprofen creme at 5% can be envisaged for clinical examination for the treatment of circumscribed rheumatic and traumatic diseases.

Administration, Topical↗
PubMedDate not supplied

Effect of trabecular aspiration on early intraocular pressure rise after cataract surgery.

PURPOSE: To evaluate the efficacy of a new trabecular aspiration technique on intraocular pressure (IOP) immediately after cataract surgery. SETTING: University Eye Hospital of Cologne, Germany. METHODS: This prospective, double-masked study comprised 48 of 100 patients having extracapsular cataract extraction (ECCE) who were randomly assigned to a study group. In these patients, 180 degrees of the inferior circumference of the chamber angle was treated with negative suction pressure ranging between 100 and 200 mm Hg. The other 52 patients served as a control group. Intraocular pressure was measured preoperatively and early (5 to 7 hours) and late (12 to 48 hours) postoperatively. RESULTS: There was a significant mean increase in IOP from the preoperative to early postoperative period in both the control group (20.8 mm Hg) and the treatment group (7.4 mm Hg). There was no significant difference between preoperative and late postoperative pressures in either group. A one-way analysis of covariance of the changes in pressure from the preoperative to early postoperative period showed significantly less increase (P = .0041) in the aspiration than in the control group. CONCLUSION: Trabecular aspiration was effective in reducing the amount of IOP increase in the immediate period after ECCE.

Aged↗
PubMedDate not supplied

Primary use of silicone oil tamponade in the management of perforating globe injury secondary to inadvertent local anaesthesia injection for ophthalmic surgery.

Perforating and penetrating globe injuries secondary to peribulbar and retrobulbar anaesthesia are often complicated by vitreous haemorrhage and retinal detachment. We describe the effectiveness of primary silicone oil tamponade in the repair of three perforated globes secondary to local anaesthesia for ophthalmic surgery. Three patients with axial myopia had peribulbar and retrobulbar anaesthesia for extracapsular cataract extraction (two patients) and cryotherapy (one patient). All eyes sustained a vitreous haemorrhage obscuring the view to the fundus. Retinal detachments were detected by B-scan ultrasound. In all eyes, scleral buckling, pars plana vitrectomy and silicone oil tamponade were performed as a primary surgical procedure. All the patients had complete anatomic reposition. In two patients, after two years follow-up, visual acuity was between 6/12 to 6/36 with the retina attached and no proliferative vitreoretinopathy (PVR). The third patient had blind painful eye and enucleation was performed. Primary use of silicone oil tamponade, in the management of perforated globe with retinal detachment due to local anaesthesia injection, is recommended.

Adult↗