PubMed Health⌕ Search

Biomedical subjects

B F Bradford

Publications and source records attributed to B F Bradford.

13 recordsLinked to original sources

Usual and unusual radiologic manifestations of acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection in children.

AIDS is being recognized with ever-increasing frequency in children. This article includes a discussion of the common radiographic manifestations of AIDS as well as some rarely encountered problems. It is hoped that with heightened awareness of this spectrum of radiographic findings, radiologists may contribute to a prompt diagnosis of AIDS so that appropriate short-term therapy and counseling may be instituted.

Acquired Immunodeficiency Syndrome↗

Renal metastases from osteogenic sarcoma.

A clinically and radiographically unsuspected ossified renal metastasis from a primary osteogenic sarcoma was identified by computed tomography (CT) and radionuclide bone scan. These imaging modalities play an important adjunctive role in the evaluation and follow-up of patients with primary osteogenic sarcoma.

Adolescent↗

Bronchial laceration in a newborn with persistent posterior pneumomediastinum.

A large posterior pneumomediastinum that compromised the respiratory status and reaccumulated promptly after needle aspiration, aroused the suspicion of airway laceration. Tracheogram was consistent with laceration of the right bronchus. Evacuation of air with chest tube resulted in complete resolution of pneumomediastinum and healing of bronchial tear with no recurrence following removal of chest tube after seven days.

Bronchi↗

Fetal cerebrohepatorenal (Zellweger) syndrome: dysmorphic, radiologic, biochemical, and pathologic findings in four affected fetuses.

Four fetuses with positive family histories for cerebrohepatorenal (Zellweger) syndrome (CHRS) underwent diagnostic amniocentesis or chorionic villus biopsy. Cultured amniocytes or fibroblasts from all of the fetuses displayed abnormal fatty acid ratios, and the parents elected therapeutic abortions. Dysmorphic features in one fetus consisted of micrognathia, proximal implantation of toes, and bilateral talipes equinovarus. Radiologic examination of the fetus confirmed the dysmorphic features and revealed foci of mineralization in the patellae. Biochemical analysis of three of the fetuses demonstrated markedly increased levels of very-long-chain fatty acids, both saturated and monounsaturated, in liver, kidney, adrenal, and brain. Pathologic findings consisted of premature mineralization of patellae; renal cystic tubular dilations; striated cells in adrenal fetal zone and testicular interstitium; dysplastic alterations of inferior olivary nuclei, dentate nuclei, and cerebral cortex; equivocal increases in portal fibrous tissue; and abnormal cytosomes in fetal zone adrenocortical cells, testicular and renal interstitial cells, and brain macrophages. Iron deposition, probably physiologic, was observed only in liver tissue. Distributions of immunoreactive catalase were identical in the fetuses with CHRS and age-matched control subjects. These findings document the accuracy of the prenatal diagnostic test and provide insights into the morphogenesis and pathogenesis of CHRS.

Adrenal Glands↗

Lung abscesses in children: diagnostic and therapeutic needle aspiration.

Three children aged 17 months to 17 years developed right-sided peripheral lung abscesses. Clinical signs were fever and cough. Laboratory cultures were negative, and the patients did not respond to appropriate antibiotic coverage. Under fluoroscopic guidance, purulent material was removed from the abscesses by needle aspiration. The patients became afebrile within 24 hours; none suffered complications of bleeding or pneumothorax. Cultures of the aspirate were positive for microorganisms sensitive to the prescribed treatments. A simple aspiration technique is described and proposed as useful for selected patients when surgical drainage is recommended. There was no morbidity in our cases, and recovery from a typically prolonged course was shortened by the procedure.

Adolescent↗

Primary renal candidiasis in two preterm neonates. Report of cases and review of literature on renal candidiasis in infancy.

Primary renal candidiasis and hydronephrosis were diagnosed in two premature neonates in whom systemic hypertension developed. The clinical course in these patients and in 16 patients with renal candidiasis described in the literature indicated that prematurity, use of broad-spectrum antibiotics, and use of intravenous (IV) catheters are predisposing factors. Anuria and flank mass were the initial manifestations in the reviewed cases. Only four of the 16 patients survived following either antifungal therapy or nephrectomy. Both of our patients survived after antifungal therapy with amphotericin B and flucytosine for systemic effect as well as topical instillation of amphotericin B solution via a nephrostomy. We believe that a high index of suspicion in infants at risk and early institution of antifungal therapy for systemic as well as topical effect can improve the outcome in infants with renal candidiasis.

Amphotericin B↗

Neonatal urinomas: imaging considerations.

Neonatal urinomas can be defined as encapsulated extravasations of urine occurring secondary to congenital obstructive uropathies. Since 1978, four patients with proven urinomas have been studied at the Medical University of South Carolina, three of which had posterior urethral valves and the fourth, a segmental ureteral atresia. They were classified into three major types; subcapsular, diffuse perirenal and localized perirenal. The radiologic and imaging appearances are demonstrated. We found the most efficacious approach for identification of neonatal urinomas to be renal ultrasound, voiding cystourethrography and the Tc-99m DPTA renal scintigraphy.

Ascites↗

Chest physiotherapy fails to prevent postoperative atelectasis in children after cardiac surgery.

In a prospective, randomized study, the effectiveness of chest physiotherapy (CPT) was evaluated in preventing postoperative atelectasis in children after heart surgery. Postoperative clinical variables and chest x-ray findings of atelectasis were compared in two groups: 19 patients receiving CPT and 25 patients not receiving CPT (NCPT). Chest physiotherapy was associated with significantly more frequent (p less than 0.01) and more severe (p less than 0.01) atelectasis than NCPT. Atelectasis was not significantly associated with temperature elevation, age, or presence of preoperative left-to-right shunt.

Child↗

Ultrasonographic evaluation of the gallbladder in mucocutaneous lymph node syndrome.

Hydrops of the gallbladder was diagnosed by ultrasonography in five out of ten consecutive patients with mucocutaneous lymph node syndrome (MLNS). Certain signs and symptoms were correlated with the development of hydrops. Follow-up ultrasonography revealed the return of the gallbladder to normal size in four out of four patients. One patient was lost to follow-up. Hydrops of the gallbladder in patients with MLNS appears to be a self-limiting condition with a benign course.

Child↗