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Biomedical subjects

B F Hochheimer

Publications and source records attributed to B F Hochheimer.

15 recordsLinked to original sources

Fluorescein angiography of the heavily pigmented iris and new dyes for iris angiography.

An inexpensive adapter mounted in front of the objective lens of a fundus camera permits routine fluorescein angiography of the heavily pigmented iris. Angiograms of these patients whose iris pigment was dense enough that standard methods of iris angiography would disclose little or no information were performed with the use of the adapter. For use in the study of the iris vasculature in the research laboratory, three dyes with spectral characteristics different from those of fluorescein allow angiography of the iris at different wavelengths. Angiograms using these dyes were performed on the eye of a cynomolgus monkey. The angiograms were each taken as close as possible to the same time sequence and show dramatically different filling and staining patterns.

Animals

Retinal light exposure from operation microscopes.

Several popular surgical microscopes were measured for source radiance. A method has been devised for calculating patient retinal exposure from these instruments. Retinal irradiance is seen to be surprisingly high, assuming dilated pupils and clear media. It ranges from 0.10 to 0.97 W/sq cm. This is one to ten times higher than that produced by an indirect ophthalmoscope. There is evidence linking light exposure during surgery to cystoid maculopathy (Irvine-Gass syndrome).

Humans

Retinal damage from light.

Exposure of a monkey retina to the light from a slit lamp for 40 minutes produced a visible retinal change that disappeared after four weeks. Exposures of 20, ten, and five minutes produced no visible changes. Extensive retinal damage was produced in the macula of the other eye of the monkey by a one-hour exposure to the light from an operation microscope. This damage was almost unchanged one year later. Exposure of the monkey retina from the same operation microscope, for the same length of time, with the blue light filtered out, produced a much smaller lesion that, after one year, could not be seen visibly but was detected with fluorescein angiography.

Animals

Indocyanine green dye fluorescence and infrared absorption choroidal angiography performed simultaneously with fluorescein angiography.

The sensory retina of the eye is nourished by two essentially separate blood circulations. The more superficial of these, the retinal circulation, is easily evaluated by direct visualization or routine fluorescein angiography. However, the underlying choroidal circulation, which is attributed with maintenance of the outer layers of the retina is not easily visualized due to the pigment epithelial layer and choroidal pigment. Fluorescence and infrared absorption angiographic techniques using indocyanine green (ICG) dye, which can be used to evaluate the choroidal circulation routinely, are described in this paper. A method is also described which can provide these angiograms simultaneously with standard fluorescein fluorescence angiograms of the retina. Finally, a comparison of all three types of angiograms is made. Limitations to the resolution of fundus details in angiograms imposed by optics of the fundus camera, photographic films, and optics and anatomy of the eye are examined.

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