Evaluation of the effect of colloid (Haemaccel) on the bleeding time in the trauma patient.
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Adult↗
Biomedical subjects
B F Jacobson
Publications and source records attributed to B F Jacobson.
Fluoxetine and hemostatic function: a pilot study.
BACKGROUND: Isolated case reports have appeared implicating fluoxetine as a cause of impaired hemostatic function. The authors attempted to investigate this phenomenon. METHOD: The hemostatic function of 10 patients with DSM-III-R major depression was investigated before and after a trial of treatment with fluoxetine. The tests included international normalized ratio, partial thromboplastin time, factors II, V, VII, VIII:C, IX, X, XI, XII, fibrinogen, thrombin time, bleeding time, euglobulin lysis time, protein kinase C, antithrombin, platelet counts, D dimer, lupus inhibitor, and platelet sensitivity studies to the following agonists: adenosine diphosphate, epinephrine, collagen, and arachidonic acid. Hemostatic data on a patient with a drug-related bleeding episode are not available. RESULTS: No significant difference was found in any of the parameters tested. CONCLUSION: This study failed to demonstrate any compromised hemostatic function associated with fluoxetine therapy. However, the possibility of a type II statistical error exists. It is possible that bleeding events may occur as an idiosyncratic reaction to fluoxetine treatment.
Adult↗
Role-model concepts before and after the formal professional socialization period.
Physical therapy students in baccalaureate-degree programs used a forced-choice Q sort of 49 characteristics of physical therapists to describe their concepts of a physical therapy role model at the beginning and again at the end of basic professional training. In ranking the items with the 10 highest mean values (most descriptive) for each sorting, two items represented technical and eight items represented personal characteristics. The same nine items remained highest for both Q sorts. In comparing the high-ranking items to those rankings of sortings performed by recent graduates and by physical therapists, six items were the same. The majority of the correlations between the students' pretraining and posttraining Q-sort scores were significant, with moderate degrees of correlation. The investigator concluded that physical therapy students' role-model concepts were fairly similar before and after professional training. Personal, rather than technical, characteristics best described the physical therapy role model.
Clinical Competence↗
Characteristics of physical therapy role models.
This study examined the personal and technical characteristics used in an investigation of role modeling in physical therapy. Recently graduated physical therapists performed a forced-choice Q sort composed of 49 physical therapist characteristics to describe 1) themselves, 2) their model academic instructor, and 3) their model clinical instructor. A significant difference between the frequency of personal and technical characteristics placed in the Most Descriptive section resulted for the self sort. The 10 characteristics ranked by highest mean values were all personal for self sorts, the majority were personal for the clinical model and combined sorts, and were equally divided between personal and technical for the academic model sorts.
Adult↗
Mechanism of thrombosis caused by sclerotherapy of esophageal varices using sodium tetradecyl sulphate.
The mechanism of thrombosis following intravariceal injection of sodium tetradecyl sulphate (S.T.D.) was investigated with respect to effects on the vascular endothelium, the coagulation cascade, and platelet function. Using an umbilical cord model designed to simulate blood flow over the endothelium, it was found that S.T.D. is a potent toxin for endothelial cells in that brief exposure to even low concentrations of the agent were effective in stripping endothelium over a considerable distance, exposing highly thrombogenic endothelium in the process. Effects on coagulation and platelet function were found to be dependent on concentration. Diluted S.T.D. induced a hypercoagulable state, possibly in consequence of a selective inhibition of the physiological anticoagulant, protein C, and promoted platelet aggregation. Higher concentrations inactivated the coagulation cascade and lysed platelets completely. These results suggest that intravariceal infusion of S.T.D. at considerable dilution may be at least as effective in inducing thrombosis as standard dosage, and possibly more so.
Blood Coagulation↗