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Biomedical subjects

B F Jones

Publications and source records attributed to B F Jones.

At least 19 recordsLinked to original sources
PubMed1995

Ancylostoma caninum: metalloprotease release coincides with activation of infective larvae in vitro.

Infective stages of several nematode parasites are known to release proteases in excretory/secretory products. These enzymes are believed to facilitate tissue invasion, although direct evidence is lacking. For these investigations, we employed an assay that uses the resumption of feeding as a marker for early events in the infectious process. When Ancylostoma caninum third-stage infective larvae are stimulated to feed in vitro, they release proteases of approximately 50,000 and 90,000 molecular weight, as determined by substrate gel electrophoresis. The enzymes are inhibited by the zinc chelator 1,10-phenanthroline, but not by the nonchelating isomer 4,7-phenanthroline, indicating that the proteolytic activity is zinc-dependent. Both compounds inhibit in vitro feeding, although inhibition by 1,10-phenanthroline is zinc-dependent, whereas inhibition by 4,7-phenanthroline is zinc-independent. The specific release of proteases associated with the initiation of feeding suggests that the metalloprotease serves an integral function in the transition of the free-living stage to parasitism.

Ancylostoma↗
PubMed1995

Molecular pathobiology of hookworm infection.

Within the past 2 years, progress has been made in the identification, isolation, and cDNA cloning of several macromolecules from hookworms. While the predicted amino acid sequences of some cDNAs resemble those from other nematodes, such as Caenorhabditis elegans, other cDNAs are unique to hookworms. Studies are under way to evaluate the function of these recombinant hookworm polypeptides with respect to the biology of hookworms in experimental animal models. The recombinant polypeptides are also under evaluation as vaccine targets and as natural products used in the treatment of human cardiovascular and autoimmune diseases.

Ancylostomatoidea↗
PubMed1994

Interphalangeal joint arthrodesis.

Interphalangeal joint fusion is a salvage procedure to achieve stability and pain relief and to correct deformity. The multiple fixation techniques for fusion are outlined. Paramount to successful arthrodesis are appropriate preparation of the joint surfaces and careful positioning and coaptation of the bone ends. If this is not accomplished, regardless of fixation technique, a pseudoarthrosis will ensue.

Arthrodesis↗
PubMed1991

Acute renal failure due to acute pyelonephritis.

We report a case of biopsy-proved acute pyelonephritis which caused acute renal failure. Despite appropriate antibiotic therapy, recovery of renal function was slow and incomplete. Renal papillary necrosis was an apparent complication, which the patient may have been predisposed to by alcoholism. Although rare, acute pyelonephritis is an important consideration in the differential diagnosis of acute renal failure because of the need for specific therapy.

Acute Kidney Injury↗
PubMed1990

Analysis of videotaped consultations to certify competence.

The assessment of videotaped genuine consultations in order to provide feedback to the learner is now a well accepted part of postgraduate training for general practice. This article reports on a pilot study which investigates the adaptation of videotape assessment of genuine patient consultations as an alternative to the present simulated patient interview segments of the examination for Fellowship of the Royal Australian College of General Practitioners. In particular, the study addresses: the feasibility and cost of collecting and assessing a suitable range of videotaped consultations using portable videocamera equipment and remote examiners; the interobserver reliability of four independent examiners; and the correlation between scores on two different rating scales. The results demonstrate that the assessment of videotaped genuine consultations has the potential to become a means of end-point assessment of clinical competence. The problem of how to collect videotapes of a suitable range and number of consultations to permit a candidate to demonstrate proficiency needs to be addressed and will be followed up in a trial of the method during 1990.

Australia↗
PubMed1989

Xanthogranulomatous pyelonephritis in a renal allograft: a case report.

We report a case of xanthogranulomatous pyelonephritis in a renal allograft. The kidney was not removed and there was an initial response to antibiotic therapy, with amelioration of toxicity and improvement in renal function. However, the kidney failed 10 months later in association with histological changes of chronic rejection.

Anti-Infective Agents, Urinary↗
PubMed1985

Fracture of the cervical spine in ankylosing spondylitis.

The radiological features, clinical findings and mortality rates of patients with ankylosing spondylitis complicated by cervical trauma have been reviewed. All patients had long-standing disease and half had sustained their fractures as a result of trivial accidents. There were 19 cervical fractures in 18 patients, which were chalkstick in type and occurred predominantly at the 6th and 7th cervical levels. Ten fractures passed through the upper part of the vertebral body, one through the mid-vertebral body and the final eight were through the disc space. The site of the fracture line was related to neurological outcome. Those patients whose fracture line ran through the disc space had significantly less neurological injury and a much better prognosis. Distraction at the fracture site had some relation to prognosis but horizontal displacement and angulation were not found to be of importance. This study confirms that cervical fracture with neurological complications may follow minor trauma in ankylosing spondylitis. The site of the fracture in relation to the vertebral bodies and discs appears to be of some prognostic relevance and careful radiological assessment of all patients with ankylosing spondylitis and cervical injury should be undertaken.

Adult↗