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Biomedical subjects

B F Nazarov

Publications and source records attributed to B F Nazarov.

6 recordsLinked to original sources
PubMed1990

[Assessment of fluid balance and several hemodynamic parameters in lung surgery using the method of impedance plethysmography].

The hemodynamic effects of different modes of controlled ventilation (CV) were studied by means of impedance plethysmography in 52 anesthetized patients during surgery on the lungs, trachea, and bronchi. To adapt this investigation technique to the conditions of the operating room, a specially designed device was applied for extracorporeal measurement of electric resistance of the blood flow. It was found that impaired transcapillary exchange of fluid in the lungs and its accumulation in the interstitial spaces were secondary to the operated lung collapse irrespective of the composition of the inhaled gas mixture used for the controlled ventilation of the contralateral lung. A differential approach to the ventilation of the dependent and independent lungs using the conventional and high-frequency CV modifications allows for an optimal compensation for the damaged transcapillary exchange of fluids in the lungs, is most physiological, sparing, and organ-saving.

Body Fluids↗
PubMedDate not supplied

[Assessment of unbalance in water compartments of patients with gestosis].

The water-sector misbalance was studied in 53 puerperants. The method of bio-impedance spectrometry was made use of to determine the total body water, extra-cellular- cellular- and interstitial water as well as the circulating blood volume. The levels of extra-cellular and interstitial water were found to be reliably higher in patients with moderate gestosis on day 1 after delivery versus healthy subjects. Stable trends towards normalizing the volumes of extra-cellular and interstitial water were registered by day 5. As for patients with sever gestosis, a reliably increasing total body water as well as extra-cellular and interstitial water persisted in them by day 5 after delivery versus the controls.

APACHE↗
PubMedDate not supplied

[Postpartum emergencies: some aspects].

The critical states occurring during pregnancy, labor, and early puerperium were analyzed. Seventy puerperas treated at intensive care units (ICU) were examined. The patients were divided into 5 groups: 1) those with preeclampsia (n = 15); 2) eclampsia (n = 22); 3) massive blood loss (n = 17); 4) pyoseptic complications (n = 10); 5) acute respiratory failure (n = 6). The APACHE II scale severity was 22 +/- 5.3 scores. The mean age of puerperas is 29.2 +/- 7.2 years. Total mortality was 14.3%. Parametric and non-parametric statistic methods were used to analyze the reasons for referral of the patients to ICU, their age composition, the association of an outcome to the time of their referral to ICU, the duration of stay there and at hospital, mortality, the time of controlled ventilation, the incidence of multiorgan failure. The common reasons for referral of the puerperas from maternity homes to ICU were eclampsia, preeclampsia, and massive blood loss. Acute respiratory distress syndrome (52.9%), encephalopathy (44.3%), coma (47.1%), and intestinal insufficiency (38.6%) were predominant in the pattern of multiorgan failure in intensive care obstetric patients. When emergencies occurred in puerperas, earlier referral from maternal homes to ICU caused a reduction in mortality from 33.% at referral on day 3 after their occurrence to 23.5% at referral on day 2, and to 11.5 at referral on day 1.

Adult↗
PubMedDate not supplied

[Use of the solutions of hydroxyethyl starch and reamberin in the combined treatment of severe gestosis].

The effects of the solutions of hydroethyl starch (HES) and reamberin on hemodynamics, metabolism, and water-sector disorders were studied in patients with severe gestosis. The study covered 42 puerperas who were divided into 3 groups: 1) 10 patients with severe gestosis and normal acid-alkali balance (AAB); 2) 10 with severe gestosis and metabolic acidosis; 3) 22 pueperas with physiological single pregnancy (a control group). Group 1 patients were given infusions of 6% HES solution, 5-6 ml/kg; Group 2 received in addition to 6% HES solution in the above dose infusions of 1.5% reamberin solution, 5 ml/kg. In patients with severe gestosis, hemodynamic, water-sector, and metabolic monitoring on puerperal days 1-5 were found to identify changes in oxygen supply and consumption, water balance, and AAB. In Group 1 patients, HES infusion on days 1-2 after delivery decreased the content of systemic water, extracellular and interstitial fluid, increased oxygen supply; in Group 2, combined infusion therapy with GES and reamberin on puerperal days 1-2 led to an increase in oxygen supply and consumption and a reduction in interstitial hyperhydration and to normalization of AAB.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Lipid peroxidation processes in the blood of patients during thoracic surgery].

Lipid peroxidation processes (malonic dialdehyde, parameters of induced Fe(2+)-chemiluminescence) have been studied in 22 patients operated on for diseases of the lungs and mediastinum and 15 patients subjected to heart surgery for ischemic disease. It has been shown that the severity of the disease depends on the activity of lipid peroxidation and the presence of a toxic product, malonic dialdehyde, in the blood plasma. The incidence and severity of postoperative complications were also higher in patients with intensive lipid peroxidation. The necessity of preventive therapy with antioxidants both in the pre- and postoperative periods has been substantiated.

Hematologic Tests↗