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B F Wu

Publications and source records attributed to B F Wu.

8 recordsLinked to original sources
PubMed1990

Effect of selenium on aflatoxin hepatocarcinogenesis in the rat.

The effects of selenium (Na2SeO3) on aflatoxin B1 (AFB1)-induced hepatic neoplasia were studied in the rat. Putative preneoplastic foci and nodules composed of basophilic, eosinophilic, and clear cells developed early. Basophilic foci were seen first; in the later stages basophilic and eosinophilic nodules predominated. At each stage the AFB1 + Se groups showed fewer and smaller foci and nodules than the AFB1 - Se group. The number of foci in the AFB1 + 3 ppm Se group and their mean area were smaller than those in the 6 ppm Se + AFB1 group. At the end of the experiment hepatocellular carcinoma (HCC) was found in 11/18 rats (61%) of the AFB1 - Se group. HCC was not found in either of the groups given AFB1 + Se. We conclude that Se had an inhibitory effect on the initiation and promotion stages of AFB1-induced preneoplastic foci and nodules. Se also prevented progression of these nodules to HCC even after cessation of AFB1 administration. The inhibitory effect of Se at 3 ppm was greater than at 6 ppm. The 6 ppm Se group also showed evidence of toxicity.

Aflatoxin B1↗
PubMed1982

Uveal melanoma in China.

We reviewed 65 cases of uveal melanoma from the Shanghai Eye, Ear, Nose, and Throat Hospital between 1956 and 1979. These 65 cases occurred at a rate of 4.5 cases per 10,000 inpatients on the ophthalmology service. Uveal melanoma is more frequently encountered in China than previous reports have suggested. In China, as in the United States, uveal melanoma is the most frequently occurring primary intraocular neoplasm in adults. We observed a strikingly younger age distribution of our cases; almost 20 percent of cases in our series involved patients between the ages of 19 and 30. The largest number of cases was seen in the fifth decade. However, only 5 cases (8 percent) were seen in the sixth decade. Fundus lesions, which were observed to stimulate choroidal melanoma, are similar to those encountered in the United States. One contrast was the importance of inflammatory lesions in the differential diagnosis of choroidal melanoma. Management of cases was surgical in all instances. A lower percentage of spindle cell tumors and a higher percentage of epitheloid tumors were seen than in most Western series.

Adult↗
PubMed1982

Uveal tuberculosis.

Ocular tuberculosis should be considered in the differential diagnosis of panophthalmitis, uveitis, and intraocular neoplasms. We have presented 6 cases illustrating some of the clinical and pathological characteristics of two types of ocular involvement, acute tuberculous panophthalmitis and ciliary body tuberculoma. The former should be entertained when panophthalmitis or uveitis occur in debilitated patients with obvious systemic tuberculosis foci. Ciliary body tuberculoma should be suspected in relatively healthy individuals with a history of tuberculosis and an intraocular mass. The diagnosis is confirmed by positive cultures or the identification of the organism by acid-fast stains. Typical histopathology in the appropriate clinical setting is sufficient to start specific antituberculous therapy, which should be used in all cases.

Adolescent↗