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Biomedical subjects

B Faibisoff

Publications and source records attributed to B Faibisoff.

10 recordsLinked to original sources

Reconstruction of large cranial defects in the presence of heavy radiation damage and infection utilizing tissue transferred by microvascular anastomoses.

Six cases of large defects of the scalp, skull, and dura following tumor ablation and radiation are presented. Each was accompanied by chronic infection in the irradiated defect. Efforts to reconstruct the resulting defects with local flaps were not successful. One-stage reconstruction was then accomplished in each case utilizing a latissimus dorsi musculocutaneous or myo-osteocutaneous free flap transferred by microvascular anastomoses. The versatility of the latissimus dorsi musculocutaneous and/or osseous flap allows single-stage reconstruction of these complex defects.

Adult↗

Wegener's granulomatosis in childhood: cutaneous manifestations as the presenting signs.

Wegener's granulomatosis (WG), characterized by a necrotizing granulomatous vasculitis, is a rare systemic disease particularly infrequent in children. We report an unusual case of WG in a 16-year-old male patient in whom the cutaneous manifestations were the presenting signs that preceded the upper respiratory symptoms by several months. In addition, the finding of a calcified pulmonary lesion has never been reported in association with WG. Accurate diagnosis of early skin lesions is important in view of the available effective therapy. Clinical and pathologic features of WG and treatment are reviewed.

Adolescent↗

Dysplastic nevus syndrome (B-K mole syndrome).

Six cases of dysplastic nevus syndrome were diagnosed at this institution. Two cases of the familial form of the dysplastic nevus syndrome (B-K mole syndrome) are discussed in detail to demonstrate the clinical pattern and variance of the genetic expressivity. The reader is also alerted to the possibility of a melanoma occurring in a clinically nonaffected offspring, as a de novo melanoma. Recommendation for comparative photographic documentation and possibly improved means of treatment are discussed.

Dermabrasion↗

Muscle coverage of pressure points--the role of myocutaneous flaps.

Although myocutaneous flaps have evolved into a primary method for managing pressure sores, their value in reducing the recurrence rate by padding the pressure point is open to question. The use of muscle to cover a pressure point violates the normal soft-tissue coverage of a bony prominence and introduces a tissue that is exquisitely sensitive to ischemia. Clinical follow-up of patients who have had myocutaneous flaps for closure of pressure sores demonstrates almost total muscle atrophy. Although skin coverage is stable, the muscle bulk of a myocutaneous flap is not retained beyond one to two years. The long-term value of myocutaneous flaps in reducing the recurrence rate of pressure sores requires careful follow-up in major series of cases.

Adult↗

Management of severe forearm injuries.

A review of principles and an operative guideline for repair of severely mutilating injuries to the forearm have been set forth. These concepts and their application have been illustrated in a series of clinical cases. The following key concepts have developed from these clinical experiences: 1. The surgeon must evaluate each case based upon the potential for return of sensation and function. One cannot justify the statement that a replanted arm is always superior to a prosthesis, even if its only purpose is cosmetic. 2. Care must be taken in the emergency room to evaluate the entire patient, and not to ignore other injuries while concentrating on a mangled extremity. 3. The crush-avulsion nature of injuries seen in a large referral center necessitates aggressive debridement of damaged soft tissue and bone. Wounds that have avulsion of skin, muscle, and nerve throughout the length of the arm do not lend themselves to repair. Destruction of an elbow joint generally precludes repair. 4. A well stabilized skeleton is essential before definitive soft tissue repairs can be performed. 5. Vascular repairs are meticulously performed using magnification. All vessels are reconstructed in an effort to recreate the original anatomy. 6. Wide destruction of muscle and tendon is frequent necessitating ingenuity in connecting proximal motor units to distal tendon. After repair, early active motion of the extremity is emphasized. 7. Perhaps the strongest contraindication to reconstruction of a severely damaged upper limb is avulsion of the nerves throughout the length of the forearm. Sharply divided nerves can be repaired by group fascicular suture. Crushed, divided nerves do well with accurate epineural approximation. Crushed nerves with epineural continuity ar best treated by observation and secondary grafting as required. 8. Primary coverage of areas denuded of skin is by split graft of local transposition flaps. More sophisticated techniques may be used at a later time (myocutaneous flaps or free flaps) if further reconstruction is contemplated. 9. Dressing must be carefully applied without constricting the extremity. A protective plaster is applied beginning from above the elbow and ending in a bonnet over the hand; this allows the recovery room nurse to monitor the vascular status of the repair. 10. The physiotherapist and occupational therapist are integrated into the perioperative care. Active range of motion exercises are begun as soon as the third day after the operation. Lightweight static and dynamic splints help to restore mobility.

Adolescent↗

Free flap transfers for upper extremity reconstruction.

Ihre clinical cases are presented using different donor sites for free flap transfer to the upper extremity. The advantages and disadvantages of the 3 donor sites namely Iliofemoral, dorsalis pedis and latissimus dorsi are discussed.

Adolescent↗

The nerve gap: suture under tension vs. graft.

Conduction velocities and amplitudes of evoked responses were used in experimental models to compare reinnervation through nerve gaps sutured under tension or bridged with nerve grafts. The best results were obtained when end-to-end suture was done without tension. Regeneration through mildly stretched nerve repairs was equivalent to applying a properly tailored graft. Minimal axonal activity was exhibited by severely stretched repair sites.

Axons↗

Expanded polytetrafluoroethylene as a microvascular graft: an experimental study.

The patency rates of expanded polytetrafluoroethylene (PTFE) vascular grafts with internal diameters of 1.0-3.0 mm were evaluated in three different species (dogs, rabbits, and rats). An overall 2-week patency rate of 14 (23%) of 60 was obtained, with the exception of 10 (83%) of 12 grafts 1.8 mm in diameter inserted in the carotid arteries of rabbits. The presence of numerous variables in the structural properties of PTFE may explain the variable results reported in the literature and this study. Heparinization did not improve the results, nor did modification in suture technique. At the present time, PTFE cannot be considered an equivalent to or a substitute for autogenous vein grafts in microvascular surgery.

Animals↗