The third generation cephalosporins.
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Biomedical subjects
Publications and source records attributed to B Farber.
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Four patients on long-term follow-up for Hippel-Lindau syndrome (HLS) are presented. All had undergone nephrectomy for renal carcinoma; in 2, carcinoma subsequently developed in the remaining kidney. Because of the tendency of these tumors to develop bilaterally, wide local resection is preferable to radical nephrectomy if the tumors can be diagnosed when small and noninvasive. CT is currently the most accurate method of regularly screening patients with HLS for asymptomatic renal carcinoma.
Pelvic lipomatosis is a rare condition which may be associated with obstructive uropathy. The radiologic features may be stimulated by pelvic malignancy and, in the past, surgery has often had to be performed for confirmation of the diagnosis. A case is described in which computed tomography (CT) provided definite proof that the pelvic organ displacement was due to excessive fat. It is considered that CT may obviate the need for further workup or surgery in these patients unless exploration is required for the relief of ureteric obstruction.
Data from 10,559 men and women, age 30-64, participating in the morning and afternoon in a Chicago Health Department multiphasic screening project, were used to determine the effects of time of day and time since last meal on the values for plasma glucose one and two hours following oral challenge with 100 gm. of glucose. Mean plasma glucose values and rates of suspect glucose intolerance (based on several cutpoints) were sizeably higher in the afternoon than in the morning. In addition, plasma glucose values increased with time elapsed since the last meal, up to 10 hours postprandially. Thereafter, both one- and two-hour plasma glucose values tended to exhibit a decline. Analysis of covariance confirmed that fluctuations in glucose tolerance were related to time of day and time since last meal, but the effects of each parameter were exerted independently.
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