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Biomedical subjects

B Fearon

Publications and source records attributed to B Fearon.

At least 19 recordsLinked to original sources
PubMed1990

Malignant nasopharyngeal tumors in children.

From 1964 to 1984, 25 children with malignant tumors of the nasopharynx were seen, and their progress was followed at The Hospital for Sick Children in Toronto. Two types of malignancies: rhabdomyosarcoma and lymphoepithelioma were most prevalent with eight cases apiece. The presenting signs and symptoms were related to local and/or regional manifestations of disease. No child presented with signs or symptoms related to distant metastatic disease. The diagnosis and treatment of this series of patients are described briefly. The advent of combined treatment modalities in the past decade has improved the prognosis for nasopharyngeal tumors, especially for the rhabdomyosarcomas; in general, however, survival rates are still poor, approximating 50%.

Child↗
PubMed1988

Interferon alfa-n1 (Wellferon) in juvenile onset recurrent respiratory papillomatosis: results of a randomized study in twelve collaborative institutions.

Sixty-six patients with clinically severe juvenile-onset recurrent respiratory papillomatosis (RRP) were entered into a 12-month randomized crossover study to evaluate interferon alpha-n1 Wellferon (WFN) as an adjuvant to CO2 laser surgical excision. Eligibility required disease onset to be before age 16, and an endoscopic excision requirement of at least three operations in the 6 months immediately prior to entry. Patients were randomized to Observation versus WFN at a dose of 5 MU/m2 daily for 28 days and three times weekly for 5 months. The patient groups were comparable in extent of disease at entry. Total extent of disease was determined by a composite score derived from the number of diseased anatomic sites and extent of surface area and lumen encroachment present at each site. Standard endoscopic excisions were performed every 2 months and clinical courses compared on a basis of composite scores determined at each endoscopy. Statistically significant improvement occurred in the patient group which received WFN. We conclude that interferon alpha n-1 is an effective adjuvant to surgery in RRP management.

Adolescent↗
PubMed1987

Choanal atresia and associated anomalies.

The authors have studied 130 cases of choanal malformation. They found 53 bilateral atresias, 51 unilateral atresias and 26 cases of choanal stenosis. Fifty-seven of these cases were associated with other anomalies and 38 had at least two features of the CHARGE association (C, colobomas; H, heart defects; A, atresia choanae; R, retarded growth; G, genito-urinary defects; E, ear defects). The pathogenesis of choanal atresia in regard to the abnormal migration of neuroectodermal cells is discussed.

Abnormalities, Multiple↗
PubMed1984

Vocal cord palsy in pediatric practice: a review of 71 cases.

Seventy-one cases of vocal cord palsy were seen over a 20-year period at the Hospital for Sick Children in Toronto. Forty-four percent of the cases had a bilateral vocal cord palsy. The etiology, management and outcome of all the cases are reviewed. Of the acquired vocal cord palsies, 64% recovered spontaneously. Only 29% of the congenital vocal cord palsies recovered spontaneously. An important consideration in the management of children with vocal cord palsy is the possibility of late spontaneous recovery or compensation. There should, therefore, be no hurry to perform surgical procedures to permanently lateralize the vocal cords or arytenoids.

Abnormalities, Multiple↗
PubMed1982

Laryngeal foreign bodies in children.

Laryngeal foreign bodies (F.B.) in children are relative rare, especially in infants under one year of age, and the diagnosis and removal are difficult. The history, the clinical and radiologic findings can be misleading. Seventeen patients with laryngeal F.B. (10 of them under one year of age) are presented, and the diagnostic problems and treatment are discussed. Foreign bodies were either objects of a sharp and thin quality, e.g. an eggshell fragment, or large, e.g. a piece of meat, causing apnea and death.

Bronchoscopy↗
PubMed1981

Anesthesia and pediatric endoscopy.

An inhalation anesthetic technique applicable to all kinds of endoscopy in children is described. It provides maximum visualization for the endoscopist, permits pressurization of the airway, does not require exceptional or unusual skills, and can be successfully managed by an anesthetist utilizing universally recognized techniques of inhalation anesthesia.

Anesthesia, Inhalation↗
PubMed1980

Treatment of subglottic hemangioma with the carbon dioxide laser.

Congenital subglottic hemangioma is a potentially life-threatening lesion usually presenting in the first three months of life. Over the years, multiple treatment modalities have been advocated. However, none has been uniformly successful, and morbidity and mortality remain high. With the advent of the carbon dioxide surgical laser, it soon became apparent that this was an ideal tool for the pediatric larynx. The already documented properties of the laser have led to the application of this form of tissue destruction in 11 patients with subglotic hemangioma. This modality has proven to be a safe, effective and rapid means of treating this troublesome lesion.

Female↗
PubMed1979

Orbital-facial complications of sinusitis in children.

Although complications of sinusitis in children have lessened remarkably since and advent of antibiotics, nevertheless they still occur. In a 25-year period at the Hospital for Sick Children, 6,770 patients with the diagnosis of sinusitis were reviewed and 159 of these had orbital-facial complications. Surgical intervention was necessary in 17 to prevent more serious complications. Although there were no deaths in non-malignant disease, two patients developed permanent optic atrophy, presumably because of delayed surgical drainage. On occasion, malignant disease may simulate inflammatory processes.

Abscess↗
PubMed1979

Pediatric adenoidectomy and tonsillectomy--personal viewpoints.

A report on experience with adenoidectomies, tonsillectomies, and adenotonsillectomies carried out at the Hospital for Sick Children, Toronto in the period 1968-75. Operations were performed on 25,443 patients during this period. Reasons for the reduction in T&A operations in recent years are considered, and views are expressed regarding when such operations are indicated, age of patient for surgery, the allergic child, cleft palate patient, the presence of quinsy, cardiopulmonary changes, subluxation of cervical spines, anesthesia, and postoperative care and complications.

Adenoidectomy↗
PubMed1976

Surgical correction of subglottic stenosis of the larynx. Clinical results of the Fearon-Cotton operation.

Thirty-five cases of subglottic stenosis were treated by one of the authors during the 6-1/2 year period January 1970 to June 1976 inclusive. Six of these failed to respond to routine management by repeated dilatation or were considered unlikely to do so. These cases were treated by a new operation, the experimental aspects of which have been previously described. Two of the six cases have been successfully extubated and two others will be so in the near future. An analysis of the problems encountered and some possible solutions are presented, as is a brief description of the operative procedure. The carbon dioxide gas laser would appear to have an important part to play in the management of glottic and subglottic webs, but its value has yet to be proven.

Cartilage↗
PubMed1976

Laryngeal papillomatosis in children.

Thirty-one cases of juvenile papillomatosis of the larynx treated in the Department of Otolaryngology at the Hospital for Sick Children are reviewed. The incidence, pathology, and etiology of laryngeal papillomata are described. Various types of treatment reported from the literature are discussed. Favorable results have been attained by careful frequent endoscopic removal of papilloma lesions using forceps, the cryoprobe, or the carbon dioxide laser. With the use of the operating microscope, the tumor population is reduced and this may allow the circulating antibodies to be more effective on the residual tissue. Tracheotomy is avoided unless near obstruction is present. Decannulization is not advisable until the danger of obstruction from regrowth of the tumor is passed.

Bronchoscopy↗