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B Fellström

Publications and source records attributed to B Fellström.

131 records · Page 8Linked to original sources

A minicomputer system for display and rate analysis in vectorcardiography.

A system has been constructed for recording vectorcardiographic signal with a FM taperecorder. Off-line AD-conversion and analysis of rates and magnitudes of partial vectors are made with a minicomputer. The reason for studying particularly initial vectorrates is that according to our hypothesis these contain valuable information for classification of certain cardiac arrythmias according to supraventricular or ventricular impulse focus. Preliminary results confirm the hypothesis. In vectorcardiography one difficulty is to give an easily comprehensible presentation of the vectorloop. In this study a method for '3-dimensional' display has been developed, using a graphic display processor and varying intensities of the beam. The system is to a high degree man-machine interactive.

Arrhythmias, Cardiac↗

PDGF-BB, but not PDGF-AA, stimulates calcium mobilization, activation of calcium channels and cell proliferation in cultured rat mesangial cells.

The effects of different isoforms of platelet-derived growth factor (PDGF) on cellular growth and on cytoplasmic Ca2+ levels in mesangial cells using a microfluorometric system and the calcium indicator FURA-2 were investigated. A rapid increase of cytoplasmic calcium in response to PDGF-BB was found and in the presence of 1.25 mM extracellular calcium, the resting level of cytoplasmic calcium following the initial peak was significantly increased compared with a calcium-free medium, but was completely attenuated with the calcium channel blocker verapamil (50 microM). PDGF-AA did not cause any increase in cytoplasmic calcium. In growth arrested MC PDGF-BB, but not PDGF-AA, also enhanced cell growth. It is concluded that cultured rat mesangial cells react to PDGF-BB but not to PDGF-AA with a rapid mobilization of intracellular calcium followed by subsequent activation of calcium channels and a stimulation of cell growth. A PDGF-BB driven mechanism for MC proliferation in inflammatory and metabolic glomerular diseases is suggested.

Animals↗