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Biomedical subjects

B Fixa

Publications and source records attributed to B Fixa.

At least 73 records · Page 4Linked to original sources
PubMed1979

Leucocyte migration inhibition test with two gastric antigens in pernicious anaemia and in simple atrophic gastritis.

Leucocyte migration inhibition test was used for evaluation of cell-mediated immunity in patients with pernicious anaemia (PA) and simple atrophic gastritis (SAG). As antigens microsomal antigen from gastric mucosa of swine foetus and relatively pure hog intrinsic factor (IF) were used. Significant differences were found between PA and SAG with microsomal antigen, but not with IF. It was concluded, that the microsomal antigen might be more active than IF. This observation could contribute to explane the higher incidence of parietal cell antibody than that of IF antibody in PA patients.

Anemia, Pernicious↗
PubMed1979

Non-specific leucocyte migration inhibition of gynaecological carcinoma patients.

Leucocyte migration inhibition in the presence of tumour crude ovarian tissue antigen was demonstrated in 64.51% of ovarian cancer patients, in 58.18% of other gynaecological carcinoma patients and in 19.04% of healthy individuals. Patients with benign ovarian disease showed 12.5% leucocyte migration inhibition. No significant difference was seen between results obtained in the presence of ovarian carcinoma antigen and normal ovary antigen.

Antigens↗
PubMed1978

Skin test reactivity in inflammatory bowel disease in the United States and Czechoslovakia.

Inflammatory bowel disease (IBD) patients in the United States of America (USA) and Czechoslovakia (CSSR) were categorized by clinical, pathological, and radiological criteria as having Crohn's disease (CD) or ulcerative colitis (UC) and were tested with five skin test antigens [Candida, mumps, purified protein derivative (PPD), streptokinase-streptodornase (SK-SD), and trichophytin] at two different dilutions in an attempt to elicit some evidence of anergy. No significant differences were encountered between the USA and CSSR populations or between any patient group and its controls.

Allergens↗
PubMed1978

The cell-mediated immunity in patients with malignant melanoma.

Cellular immunity in 22 patients with malignant melanoma and the blocking effect of their sera was followed by means of the leukocyte migration inhibition test. The migration of peripheral leukocytes from malignant melanoma patients was significantly inhibited in the presence of malignant melanoma antigen in 50% of examined patients and only in 2 cases in controls. The blocking activity of serum on migration inhibition was observed in 3 melanoma patients. From the results of the tests performed related to the two-years-course of the disease the conclusion may be drawn that the prognosis in patients with proved cellular hypersensitivity to malignant melanoma antigen is more favorable than in anergic individuals.

Adolescent↗
PubMed1975

Ageing and autoimmunity.

A total of 483 healthy persons from Czechoslovakia, divided into three age groups (below 40, 41-60 and above 61 years) were examined for eight types of autoantibodies (antibodies to epithelial cells and to colloid of thyroid gland, parietal cell antibodies, antibody to intersititial duct cells of parotis and to adrenal cells, anti-nuclear and anti-mitochondrial antibodies, intrinsic factor antibodies). A significantly increased occurrence was observed in the oldest age group, the results being more manifest in women. A conspicious increase was seen particularly in the thyroid antibodies. The results correspond to those of other authors from different geographic areas.

Adrenal Glands↗
PubMed1975

Ageing and cell-mediated immunity.

The lymphocyte transformation test with phytohemagglutinin as mitogen estimated according to the incorporation of 2-(14)C-thymidine in DNA was used as an indicator of cell-mediated reactivity in 53 healthy subjects. Three age groups were examined: up to 20 years (21 subjects), 21-40 years (10 subjects) and over 70 years (22 subjects). The responsiveness of lymphocytes decreased significantly with age. In the highest age group 12 pathologically low values were found.

Adolescent↗