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Biomedical subjects

B Foss

Publications and source records attributed to B Foss.

5 recordsLinked to original sources
PubMed1996

Human T lymphocyte activation in the presence of acute myelogenous leukaemia blasts: studies of allostimulated interferon-gamma secretion.

Normal peripheral blood mononuclear cells (PBMC responders) were cultured together with non-irradiated allogeneic PBMC (more than 95% leukaemia blasts) derived from patients with acute leukaemia (referred to as leukaemic PBMC stimulators). Cytokine secretion was determined as cytokine concentrations in supernatants. Both normal PBMC and enriched CD4+ and CD8+ T cells responded to allostimulation with interferon (IFN gamma) secretion. Interleukin-I (IL-1) receptor antagonist and IL-2-neutralizing antibodies decreased IFN gamma secretion. Exogenous IL-1 beta, IL-2 and IL-7 increased allostimulated IFN gamma secretion, whereas decreased levels were seen in the presence of IL-6, IL-10 and granulocyte-colony-stimulating factor (G-CSF). During allorecognition IFN gamma-neutralizing antibodies decreased acute myelogenous leukaemia (AML) blast secretion of G-CSF. We conclude that (i) both CD4+ and CD8+ T cells show allostimulated cytokine secretion in response to allogeneic stimulator cells containing a dominating population of native, cytokine-secreting leukaemia blasts, and (ii) IFN gamma released during this response can modulate the function of allogeneic AML blasts.

Adult↗
PubMed1987

Evaluation study of the booklet "Preschoolers and Poisons".

Accidental poisonings remain a serious problem among young children. The booklet, "Preschoolers and Poisons," is part of the effort to educate the parents and caretakers to create a safe environment for their children. A pre-experimental, pre- and post-test, one group design, was employed with the purpose of determining if mothers of young children seen in St Paul Ramsey Medical Center's Pediatric Clinic had a gain in knowledge about accidental childhood poisoning and its prevention, and if they initiated preventive behavior after reading "Preschoolers and Poisons." The mothers' evaluation of the booklet was also solicited. A personal interview was used to collect data from a convenience sample of 40 mothers. The pre-test took place in the clinic, and the post-test over the phone, with an interim of 2 to 3 weeks. All participants read the booklet; 60% read the whole booklet and 40% read sections of interest. The mothers had a significant increase in knowledge, and a relationship between gained knowledge and age of the youngest child was found. The data showed that the Caucasian mothers in the study had a higher level of knowledge about accidental childhood poisonings and its prevention both before and after reading the booklet. Almost half of the mothers initiated preventive behavior. There was a positive relation between the initiation of preventive behavior and the age of the mother. Evaluations of the booklet were positive. Only 10% noted negative aspects such as the booklet being too short and missing a list of poisonous plants, while 80% identified positive aspects, such as the use of bright colors and the organization by age.(ABSTRACT TRUNCATED AT 250 WORDS)

Child, Preschool↗
PubMed1981

Effects of prostaglandins E1 and E2 on the in vitro production of immunoglobulin by human peripheral blood lymphocytes.

The effects of PGE2 and PGE1 on the response of human peripheral blood lymphocytes to Pokeweed mitogen were studied. Addition of PGE2 inhibited IgM production. This effect was augmented by treating the lymphocytes with 2.0 mug/ml of Indomethacin. Addition of PGE1 alone had little effect but augmentation of IgM production was seen in cultures where the lymphocytes had been treated with Indomethacin and PGE1 then added. The results suggest that PGE1/E2 have a small but measurable effect on in vitro IgM production.

Cells, Cultured↗