Biomedical subjects
Publications and source records attributed to B Friedel.
Two patients, suffering from Osteosarcoma of the distal femur, were operated in 1987. A Rotatoryplasty with resecting the half of the femur and the knee joint was performed. We would like to demonstrate our experiences in the prosthetic fitting in these patients. The Rotatoryplasty improves the prosthetic comfort in these patients cured by above knee amputation in former time.
In 1976 belt usage was made compulsory for front seat passengers in the Federal Republic of Germany. Since 1984, noncompliance incurs a fine of DM 40. In 1984 belt usage was also made compulsory for back seat passengers (noncompliance not being fined). Following the introduction of the fines, the usage rates both for drivers and front seat passengers increased from about 60% to more than 90%. The number of car occupant fatalities has lowered considerably since the introduction of the fine (by about 25%). Approximately 15 to 20 percentage points of this change are probably due to this measure. Major injuries decreased noticeably as well, in particular injuries to the eyes. Belt usage on back seats is still unsatisfactory (20%), although here too, the effect on injuries of the belt is incontestable, taking into consideration occupant interaction.
The McCune-Albright syndrome consists of a combination of fibrous dysplasia of bone and endocrine lesions with abnormalities of pigmentation. The condition is rare and may be missed, as happened in our case. The case showed extreme skeletal deformities, menarche at one year and peculiar histological appearances.
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In the reported case of a severe alkylphosphate poisoning the first EEG-observation at the twentieth day after intake showed marked abnormalities although there was a complete physical and humoral recovery. Progressive normalization of the EEG occured in the following six weeks. Psychopathological symptoms of a mild apathy and slowening of reactions disappeared gradually.
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At the present time, more than 90% of the motor vehicles in the Federal Republic of Germany are equipped with seat belts. On the average, however, only one out of two drivers uses his belt. It has been established that the seat belt, considering the present rate of use, annually protects about 1700 car occupants from fatality and about 30,000 from injuries (resulting in economic savings of approx. DM 1.8 X 10(9)). If all car occupants were to observe seat-belt regulations, this gain in safety might be doubled. Experience of other countries indicates that the introduction of the fine would result in much better compliance with the regulation than has been observed thus far.
1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal) in oral doses of 150 mg/kg caused no essential changes in the EEG pattern in man. Only the alpha-rhythm of the occipital leads was more synchronized and the amplitude somewhat higher. beta-Waves increased slightly, but the delta-waves were not significantly changed. Tramadol induced no measurable alterations in the electronystagmographic recordings of quick voluntary eye movements or follow-up to-and-fro eye movements. In the optokinetic and postrotatory nystagmus, however, there was a moderate decrease in the total amplitude and maximal angular velocity of the slow nystagmic stage. The results of EEG and electronystagmographic investigations indicate that tramadol has a moderate relaxant (central depressant) effect.
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A case of enchondromatosis with an unusual course was observed. The enchondromas originated in the patellae, subsequently with rapidly spreading metaepiphyseal growth on the knee joints and distally on the medial side of the right tibia. Cold-sensitive exanthema, pigment spots, drumstick fingers, watch glass nails, dentition disorders. Since radical surgery on the right femur 8 years ago there has been no recurrence.