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Biomedical subjects

B Friis-Hansen

Publications and source records attributed to B Friis-Hansen.

At least 55 records · Page 3Linked to original sources
PubMed1979

Dietary habits and serum lipids during first 4 years of life. A study of 95 Danish children.

Early infant feeding habits, current dietary intake and serum lipids were investigated in 31 infants, age 6--10 months and 64 children, age 3--4 years. In the infants there was a correlation between serum lipid levels and the amount of saturated fat and the P/S ratio of the diet. No such correlation was found in the 3--4 year old children. Neither was there any correlation between the type and duration of early infant feeding and subsequent serum lipid levels. In both the infants and the 3--4 year old children serum cholesterol concentration correlated with the serum cholesterol concentration in each of the parents.

Adult↗
PubMed1979

Screening for hyperlipoproteinemia in 10,000 Danish newborns. Follow-up studies in 522 children with elevated cord serum VLDL-LDL-cholesterol.

Among 10 440 newborns, 522 with upper 5 percentile values for very low-low density lipoprotein cholesterol in cord serum were selected for follow-up studies. Follow-up was possible in 446 of these 522 families (85%) and familial hypercholesterolemia (FH) was diagnosed in 11. In 273 of the 522 children, serum lipids were determined between the ages of 1 and 2 years and were now found to be normal, except in the 11 children with FH. Furthermore the serum lipids were compared in subgroups of these 273 children divided according to obstetric complications (i.e. low birth-weight, perinatal asphyxia and antepartum betamethasone treatment), which may cause a rise in serum lipids at birth. No differences were found between these subgroups at the age of 1--2 years.

Cholesterol↗
PubMed1979

Arterial blood pressure elevations during motor activity and epileptic seizures in the newborn.

In nine distressed newborn infants, mean aortic blood pressure and motor activity were recorded continuously during the first two or three days of life. Six of the infants had been asphyxiated at birth, the remainder having idiopathic respiratory distress only. The results showed that mean arterial blood pressure varies synchronously with motor activity, reaching maximum values much higher than previously suspected: about 90 or 100 mmHg were recorded in several infants. In three cases focal and/or generalized epileptic seizures occurred during the recording. It was found that in these circumstances too blood pressure increases dramatically, even if the motor component of the seizure is insignificant.

Apgar Score↗
PubMed1979

Hyperlipoproteinemia in newborn infants. A study of 1025 families.

As part of a screening study for the detection of hyperlipoproteinemia in 10,000 newborns, cord serum lipids and lipoproteins were measured in detail in 1025 infants. Elevated cord serum VLDL-LDL-cholesterol could easily be identified by a rapid turbidimetric estimation of cord serum VLDL-LDL. Cord serum VLDL-LDL-cholesterol was found to be significantly higher than normal in premature, asphyxiated and beta-methasone-phenobarbital-ritodrine treated infants. Other obstetric complications, however, were not associated with hyperlipoproteinemia. Furthermore all 2050 parents had their serum cholesterol determined. 3 parents had familial hypercholesterolemia (FH). One child also had FH, though her cord serum total cholesterol and VLDL-LDL-cholesterol were normal. The 2 other children of the 3 FH parents, had normal lipids and lipoproteins both at birth and follow-up.

Cholesterol↗
PubMed1977

Low cerebral blood flow in hypotensive perinatal distress.

Hypoxic brain injury is the most important neurological problem in the neonatal period and accounts for more neurological deficits in children than any other lesion. The neurological deficits are notably mental retardation, epilepsy and cerebral palsy. The pathogenesis has hitherto been poorly understood. Arterial hypoxia has been taken as the obvious mechanism but this does not fully explain the patho-anatomical findings. In the present investigation we have examined the arterial blood pressure and the cerebral blood flow in eight infants a few hours after birth. The 133Xe clearance technique was used for the cerebral blood flow measurements. The study confirmed that perinatal distress may be associated with low arterial blood pressure, and it was shown that cerebral blood flow is very low, 20 ml/100 g/min or less, in hypotensive perinatal distress. It is concluded that cerebral ischaemia plays a crucial role in the development of perinatal hypoxic brain injury.

Asphyxia Neonatorum↗
PubMed1977

Cord serum lipid and lipoprotein-cholesterol values in normal and betamethasone-treated newborns of varying gestational age.

Cord serum total cholesterol, very low density lipoprotein-, low density lipoprotein-, high density lipoprotein-cholesterol and triglyceride was determined in 30 AGA infants and 35 SGA infants born between the larger than or equal to 37th less than or equal to 42th week of gestation and in 26 AGA infants born between the larger than or equal to 33th less than 37th week of gestation. In SGA infants significantly higher VLDL-cholesterol and triglyceride values were found than in AGA infants. In AGA infants less than 37 weeks of gestation total cholesterol, LDL-, and HDL-cholesterol concentrations were higher than in AGA infants larger than or equal to 37 weeks of gestation. In 10 betamethasone-treated AGA infants less than 37 weeks of gestation HDL-cholesterol was higher than in 16 untreated AGA infants less than 37 weeks of gestation.

Betamethasone↗
PubMed1976

Neonatal hypertriglyceridemia: a new index of antepartum-intrapartum fetal stress?

The 95th percentile value of cord serum triglyceride concentration in 82 consecutively live born infants was found to be 0.79 mmol/l. This level was arbitrarily used to define neonatal hypertriglyceridemia. A comparison between 78 normotriglyceridemic and 61 hypertriglyceridemic newborn infants showed a significant association between elevated cord serum triglyceride concentration and insufficiency of the placenta, fetal bradycardia, meconium-stained amniotic fluid and one-minute Apgar score less than or equal to 7. A significantly (p less than 0.001) greater number of infants with one or several of these four factors, indicating antepartum and/or intrapartum fetal stress were found to be hypertriglyceridemic at birth. This finding suggests that estimation of cord serum triglyceride which is easy and inexpensive might be of value for a more complete evaluation of the newborn infant, and can serve as a supplement to the Apgar Score system.

Cholesterol↗
PubMed1976

Follow-up of children of drug-addicted mothers.

During a period of 2 years (1971-72) 19 newborn infants were admitted to hospital because their mothers were drug addicts. To evaluate the prognosis in these children, 17 were followed up by a social adviser, a psychologist, and a paediatrician. During the neonatal period 16 of the infants had withdrawal symptoms, for which 11 required medical treatment. One infant died of congenital malformations. Of the surviving 18 infants 14 were discharged to their mothers and 4 went to a children's home. During follow-up, which varied from up to 2 months to up to 2 years 8 months of age, 10 of the children had to be placed in a children's home for a period. No physical abnormalities were found in the children. Motor and perceptual development were normal in 12 but in 3 speech development was delayed. Five mothers ceased to take drugs after delivery and 2 had done so during early pregnancy. The pre- and perinatal complications and the undesirable environment in which the children grow up show the need for a comprehensive treatment programme.

Child Care↗
PubMed1976

Neonatal diagnosis of familial type II hyperlipoproteinemia.

Cord serum prebeta-beta-lipoprotein concentration was measured in a radial immunodiffusion assay in 303 randomly selected, full-term infants whose parental phenotypes were unknown. Six infants had elevated concentrations, that is above a cut-off limit of 197 mg/100 ml (97.5th percentile). Three of these infants suffered from classic type II hyperlipoproteinemia, and this diagnosis was confirmed by family studies at follow-up. The three other infants and their parents were shown to be normolipemic at follow-up. The elevated cord serum prebeta-beta-lipoprotein in these three infants could be explained by highly elevated cord serum triglyceride and/or cholesterol. The 297 infants with normal cord serum prebeta-beta-lipoprotein and their parents were all shown to be normalipemic at follow-up. It is concluded that the measurement of prebeta-beta-lipoportein in cord serum allows the identification of children with familial type II hyperlipoproteinemia, if infants with transient neonatal hypertriglyceridemia and hypercholesterolemia are excluded.

Adult↗