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Biomedical subjects

B Fryklund

Publications and source records attributed to B Fryklund.

25 records · Page 2Linked to original sources
PubMed1988

Epidemiology of fecal strains of the family Enterobacteriaceae in 22 neonatal wards and influence of antibiotic policy.

The gram-negative fecal floras from 953 infants were studied upon discharge of the infants from 22 neonatal wards. More than 600 distinct phenotypes of Escherichia coli, Klebsiella spp., and Enterobacter spp. were distinguished by high-resolution biotyping. The colonization patterns observed showed considerable local and temporal variation. The major (M) strains (phenotypes), which colonized more than 10% and up to 78% of the infants in a ward (median, 23%), were Klebsiella oxytoca (15 strains), E. coli (4 strains), Klebsiella pneumoniae (1 strain), and Enterobacter cloacae (1 strain). Resistance to beta-lactam antibiotics was more pronounced among M strains than among strains of enteric bacteria colonizing few or single infants only. Local antibiotic policy influenced the colonization patterns. Despite the fact that M strains of Klebsiella spp. were usually resistant to ampicillin as well as to cephalexin and cefuroxime, their local dissemination was associated with the use of ampicillin with or without gentamicin but not with the use of cefuroxime. It thus appeared that in the neonatal setting, ampicillin posed a greater risk of local spread of certain drug-resistant bacterial clones than a newer cephalosporin, such as cefuroxime.

Anti-Bacterial Agents↗
PubMed1987

Use of indwelling urinary tract catheters in Swedish hospitals.

In a survey of 67,774 patient days in 27 Swedish acute care hospitals, an indwelling urinary tract catheter (IUTC) was in place during 12% of patient days. There were marked differences between services (from 2% in rheumatology to 49% in urology), but also between hospitals for the same type of service (general surgery, internal medicine, gynecology, orthopaedic surgery) concerning proportion IUTC days, average duration of catheterization and the indications for IUTC use. The great local variation in IUTC usage for a particular service was usually not correlated with type of hospital (district, county, or regional/teaching), ie, with the mix of patients studied. We propose that the results mainly reflect a variable local impact of infection control and that a much more restrictive use of IUTCs is possible in many wards. This condition would imply a considerable potential for reducing the incidences of urinary tract infection and bacteremia and thus, mortality among hospitalized patients in Sweden.

Aged↗
PubMedDate not supplied

Importance of the environment and the faecal flora of infants, nursing staff and parents as sources of gram-negative bacteria colonizing newborns in three neonatal wards.

Gram-negative bacteria are an important cause of invasive infection among neonates. In this study a novel fingerprinting method was used for the first time to assess the importance of various potential reservoirs of the major gram-negative enterobacteria that colonized 46 consecutive infants in three neonatal special care units during a three to four week period. Such bacteria were isolated from the oropharynx, umbilical cord and faeces in 24%, 33% and 100% of the infants, respectively. Klebsiella/Enterobacter spp. dominated over Escherichia coli and spreading (shared) over sporadic strains. Sixty-one percent of the neonates were colonized with at least one and up to six different strains shown to exist in the ward, mainly in other infants. Environmental reservoirs and the faecal flora of mothers and staff were of minor importance. Vertical transmission occurred in 12% of vaginally delivered infants and in 0% of those delivered by caesarean section.

Age Factors↗
PubMedDate not supplied

Epidemiology and attack index of gram-negative bacteria causing invasive infection in three special-care neonatal units and risk factors for infection.

Of 13 consecutive episodes of gram-negative septicemia (Escherichia coli eight, Klebsiella oxytoca four, Klebsiella pneumoniae one) among 113 infants in three special-care neonatal units studied, five episodes were epidemiologically related according to a novel fingerprinting method for enterobacteria. In ten episodes the invasive phenotype was found in the fecal flora of up to 54% of the fellow infants in the same ward and for periods of up to 70 days. Two units exchanged patients, which further promoted the transmission of invasive strains. The attack index was highest for certain E. coli strains, generally low for K. oxytoca strains, but lowest for other E. coli strains. The infants contracting septicemia had lower birth weight (p = 0.04) or were more often classified as high-risk infants than matched non-infected fecal carriers of the invasive strains (p = 0.04). In summary, gram-negative neonatal septicemia was either due to an apparently high-virulent strain capable of attacking the single full-term infant carrier or a high-colonizing phenotype of lower apparent virulence, which occasionally attacked a high-risk infant among a large number of infants colonized.

Birth Weight↗
PubMedDate not supplied

Cleaning and disinfection of reusable items in Swedish hospitals.

1. In Sweden, every ward has one or two utility rooms equipped with a washer disinfector for cleaning and disinfection of such items as instruments and wash basins, and a flusher disinfector for cleaning and disinfection of bedpans/urinals and emptying of fluids. 2. Thermal disinfection of reusable items is accomplished in a sealed chamber with an efficient, controlled process--which is a simple, inexpensive, and reliable method for high-level disinfection. 3. The use of flusher and washer disinfectors in hospital wards, surgery areas, and critical care units is recommended to minimize the use of single-use items and provide a safer environment for patients and personnel.

Cross Infection↗