Biomedical subjects
Publications and source records attributed to B G Cherevatov.
The therapeutic efficacy and changes of clinical and hemodynamic indices due to the use of long-action nitrates were studied in 91 patients with chronic ischemic heart disease. The native drug nitrogranulong produces an essential effect on the hemodynamics resulting in a complete disappearance or reduction of stenocardia attacks, increased tolerance to physical loads as evidenced by bicycle ergometric data.
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Rheumon-Gel was used for therapy of 51 patients with rheumatoid arthritis. It has been shown that the drug has a marked antiinflammatory and analgesic action, a positive effect on a number of subjective (pain in the joints and constrained movements in the morning), objective (body temperature, edema and joint function), and laboratory (leucocyte count, ESR, C-reactive protein, titer of antistreptolysin-O and antistreptohyaluronidase) indices and therefore it can be recommended for multimodality therapy of rheumatic patients, particularly of those with rheumatoid arthritis combined with G. I. tract diseases when the use of most of the antirheumatic drugs is counterindicated.
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Seventy-six patients with chronic coronary heart disease of the atherosclerotic genesis were examined using clinical laboratory and instrumental research methods. The blood serum levels of total cholesterol, triglycerides, lipoproteins and bile acids were measured throughout the course of treatment. When hyperlipoproteinemias were divided according to phenotypes, type II hyperlipoproteinemia proved to be most commonly occurring (65.8%). The patients exhibited lower blood serum levels of bile acids as compared to control.
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The so-called safe course of acute myocardial infarction was shown to be associated with reduced left ventricular stroke output, changed phasic pattern of the systole, and peripheral arterial constriction. In infarction-related acute left-ventricular failure, a clear dissociation can be seen between the pumping function of the right and left ventricles. These changes are further aggravated by increased circulating blood volume and pulmonary blood quantity, and lowered arterial and venous flow rate. Paravascular edema adds to generalized vasoconstriction. Hypertension in the pulmonary artery network implies additional effort for right ventricular myocardium and thus prevents blood overflow to lesser circulation veins and left compartments of the heart.
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Explore the source record for details and available documents.
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Explore the source record for details and available documents.
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Explore the source record for details and available documents.
The authors studied an antianginal effect of the angiotensin-converting enzyme, for which purpose they used Capoten at 75 mg daily over two weeks in 24 patients with stable functional class II-III exertional angina. Capoten was shown to be capable of reducing occurrences of angina attacks as well as intakes of tablets of nitroglycerin for the above attacks to be arrested; besides, it lowers systolic and diastolic arterial pressure, enhances exercise tolerance, increase rate of circular shortening of left ventricular myocardium fibres, decreases total peripheral vascular resistance. In conclusion, apart from antihypertensive and positive inotropic action Capoten has a coranolytic effect.