Awareness of testicular tumours in genitourinary medicine clinics.
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Biomedical subjects
Publications and source records attributed to B G Ferrie.
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The incidence of urethral stricture following aortic graft surgery was investigated retrospectively in a group of 127 men. They had been catheterised prior to their operation with latex catheters. One man had been treated for a stricture 9 months after his operation. Information about post-operative urinary symptoms was obtained from a further 94 surviving patients by postal questionnaires sent at least 12 months following surgery. Eight patients underwent urological review including, where indicated, urethrography under antibiotic cover; 3 patients were identified with urethral strictures, an incidence of 3.2%. This is similar to that occurring after cardiac surgery, and urethral strictures should be considered a hazard whenever catheters are used in surgical procedures.
Forty-five patients awaiting prostatectomy participated in a double-blind study of phenoxybenzamine 10 mg/day for 5 weeks. Objective measurements of peak urine flow, voided volume, residual urine and frequency of micturition and nocturia showed no significant difference between phenoxybenzamine and placebo. Patients taking phenoxybenzamine had a significantly greater improvement in hesitancy and flow symptoms than those on placebo. Side effects occurred in 47.6% of patients on phenoxybenzamine and 22.2% of those on placebo. In this study phenoxybenzamine 10 mg/day was ineffective in patients with benign prostatic hypertrophy.
In an earlier series of 100 men followed up for between 3 and 12 months after coronary artery bypass grafting, the incidence of urethral stricture was 2%. These patients have now been followed up for between 15 and 24 months and the incidence of urethral stricture has risen to 5.2%. Latex catheters were used in these patients. A separate group of 117 men underwent coronary artery bypass grafting and were catheterised with silicone catheters. They were followed up for between 12 and 28 months and no urethral strictures were found. It is recommended that silicone catheters be used routinely for short-term catheterisation in men undergoing cardiac bypass surgery.
Peak urine flow rates were measured in 83 men before coronary artery bypass grafting. The patients were grouped according to the method of Drach et al. [1] into those with normal, equivocal or abnormal flow rates. No cases of urine infection occurred in any of the 3 groups and only 2 patients in the group with abnormal peak flow developed urine retention. This was not statistically significant. Peak urine flow did not appear to be useful in predicting urine retention after coronary artery bypass grafting.
A case of ureterocolic fistula as a result of an impacted lower ureteric stone is reported in which the diagnosis was made on antegrade pyelography.
There were 29 patients under the age of twenty-five years in a series of 230 patients with genitourinary tuberculosis. Younger patients were less likely to have had previous tuberculosis but more likely to have a family history of tuberculosis. Abdominal or loin pain was a more common presenting feature in those under twenty five, and they were less likely to require surgery than older patients.
Two hundred and thirty patients with genito-urinary tuberculosis presenting between 1970 and 1979 were reviewed. In 22 per cent there was a history of previous tuberculosis and a family history in 14 per cent. Night sweats and weight loss were uncommon. The mean duration of medical treatment was 17 months. Surgery was necessary in 49 per cent of patients but reconstructive procedures were only performed in 7 per cent of cases. The mean follow-up period after diagnosis was 46 months. Patients with initial renal calcification were followed-up for a similar time to those with no calcification. Complications during follow-up were no more common in those with initial renal calcification than in those without this feature. With the exception of 1971 and 1972, there was a steady incidence of 20 or so new cases of genito-urinary tuberculosis per year in Glasgow.
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Eleven patients with bladder tumours classified T2 (2 cases), T3 (6 cases) or T4 (3 cases) - and 3 patients with radiation cystitis - were assessed as being beyond the scope of even palliative surgery, severe haemorrhage being present in all cases. One patient was treated by total cystectomy and urinary diversion 21 months after intravesical formalin installation. Palliative haemostatic treatment was instituted in all cases by intravesical instillation of a 10% formalin solution under general anaesthesia. Two patients received 3 and 5 instillations respectively, the former over 3 weeks and the latter over 9 months. The bladder was filled completely and an indwelling catheter introduced, the formalin solution being left in the bladder for from 3 to 20 minutes (mean: 13 minutes). Haematuria was absent after from one to 21 days (mean: 5.3 days) in 13 cases. The 14th patient died before arrest of haemorrhage. Survival after instillation was from 3 days to 32 months (mean 6.8 months). The outcome was fatal within 3 months or less in 8 cases and 6 patients died within 2 months of acute renal failure, one within 3 days of instillation. In 5 cases the treatment with formalin reduced bladder capacity to less than 100 ml. Other complications included acute infection of thigh, ruptured bladder, retroperitoneal fibrosis and severe frequency and nocturia (1 case each), and this procedure should therefore be reserved for terminal cases unable to support more aggressive therapy.
65 men undergoing elective transurethral resection of the prostate under the care of one urologist entered a randomised controlled trial using Cefuroxime. Patients were excluded if they had received antibiotics in a 2 week period before surgery, if they had positive pre-operative urine cultures or if they had been catheterised. 58 patients completed the study. One patient in the antibiotic group and 2 in the control group developed urinary infection. The overall infection rate was 5.17%. The control and antibiotic groups were comparable as regards age and the duration of resection. One patient in the antibiotic group developed an allergic reaction. It is felt that routine antibiotic prophylaxis in patients with sterile urine undergoing elective TUR is unnecessary.
Certain occupations have a high incidence of urinary tract stone disease and in view of the potential nephrotoxic effects of metals and the heavy industry in the Glasgow area, a review of occupations of patients attending our stone clinic was done to discover if patients had been exposed to hot-metal processes. Sixty-three per cent of male patients had been exposed to hot-metal fumes for periods ranging from one to fifty years. A random population of asymptomatic stone formers discovered on epidemiologic screening showed that only 26 per cent of these patients could have had exposure to hot metals. Certain epidemiologic aspects of stone disease are reviewed. Little work has been done on occupational aspects of stone disease, and there is scope for further investigation in this area.
A double-blind cross-over trial of DDAVP was carried out in 22 patients aged between 9 and 16 years. The patients had previously failed to respond to other treatments for enuresis. While DDAVP resulted in fewer wet nights during the 14-day period of active treatment, the results did not achieve statistical significance. This is in contrast to previous reports. The dose in this study was 20 micrograms intranasally. Further studies may be valuable, possibly relating dosage to body weight.
A prospective study was undertaken to assess the incidence of urethral stricture in 105 men undergoing coronary artery by-pass grafting. A pre-operative urological history was taken and peak urine flow rates measured before surgery, and 1 week and between 6 and 8 weeks after operation. All patients were catheterised in theatre with a standard type and size of urethral catheter and details recorded of the by-pass time and the degree of hypothermia. Postoperative urological problems such as urethral discharge and haematuria were noted. In addition, 100 patients completed a postal questionnaire about urinary symptoms between 4 and 12 months after surgery. The overall incidence of urethral stricture was 2%.
An unusually high incidence of urethral stricture has been reported in men who have undergone cardiac surgery (Ruutu et al. 1982, Sutherland et al. 1983). Our experience with this condition in 1983 is reported.
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The results of in-patient bladder training in 65 women with frequency, urgency and urge incontinence are reported. There was a good initial response in 88%. By 6 months the response rate had fallen to 38%. Patients with sensory urgency appeared to do better than those with detrusor instability and it is suggested that bladder training may be indicated as primary treatment in sensory urgency. Eysenck Personality Inventory testing was carried out in 43 patients. The mean neuroticism score was high, with non-responders having a higher neuroticism score than responders. Patients with detrusor instability had a higher mean neuroticism score than those with sensory urgency. Introverted patients appeared to do better than extraverts with bladder training.
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