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Biomedical subjects

B G LAMSON

Publications and source records attributed to B G LAMSON.

18 recordsLinked to original sources
PubMed1952

Albumin and globulin circulation in experimental ascites; relative rates of interchange between plasma and ascitic fluid studied with C14-labeled proteins.

Plasma containing carbon(14)-labeled albumin and globulin, obtained by feeding epsilon-C(14)D,L.-lysine to a donor dog, has been injected intravenously and intraperitoneally into recipient dogs with experimental ascites. The circulation and interchange of total plasma protein between circulating blood and ascitic fluid have been confirmed and the participation of both albumin and globulin in this interchange has been demonstrated. Labeled albumin tends to reach equilibrium in plasma and ascitic fluid in a shorter period of time (1 to 2 days) than does globulin (2 or more days), after administration of labeled plasma by either route. Evidence is presented that the rate of transfer of albumin across the peritoneal membrane is at least three times faster than that of globulin in terms of weight.

Albumins↗
PubMed1951

Conversion of plasma protein to tissue protein without evidence of protein breakdown; results of giving plasma protein labeled with carbon 14 parenterally to dogs.

Labeled plasma proteins obtained from donor dogs, previously fed epsilon-C(14)-dl-lysine, have been given intravenously to recipient dogs. The disappearance of labeled globulin from the plasma at a rate considerably faster than albumin has been confirmed. Evidence suggesting that the mass of protein in solution in the extravascular, extracellular fluid is approximately equal to the plasma proteins in circulation has been derived from a study of the dilution of labeled plasma protein by repeated injections of non-labeled plasma protein. In a period of 7 days the transfer of C(14) from plasma to tissue proteins amounted to between 30 and 40 per cent of the activity in the labeled plasma protein injected intravenously. The conversion was accompanied by a very small loss of activity in the urine and expired air and the activity remained in the lysine residue of the liver and probably of other tissues. The data presented favor the view that plasma proteins are utilized in the body economy after partial catabolism within the cell area and provide no evidence of complete breakdown to the amino acid level.

Amino Acids↗