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Biomedical subjects

B G Lukichev

Publications and source records attributed to B G Lukichev.

At least 19 recordsLinked to original sources
PubMed2001

[Course of heart failure in patients with terminal chronic kidney failure on chronic hemodialysis].

AIM: To evaluate peculiarities of the course of cardiac failure (CF) in initiation of hemodialysis therapy (HT) in patients with terminal chronic renal failure (CRF) and 24 months after HT; to elucidate CF causes late in HT. MATERIAL AND METHODS: Cardiohemodynamics was studied in 152 patients with terminal CRF during 2 years of HT. RESULTS: At initiation of HT, cardiohemodynamics was characterized by hyperkinetic syndrome, high total peripheral resistance, weak left ventricular systolic function, diastolic dysfunction. Chronic HT for 2 years led to attenuation of hyperkinetic syndrome, improvement of left ventricular systolic function, highly increased bypass blood flow along the arteriovenous fistula. The correction of the blood flow along the arteriovenous fistula arrested manifestations of CF in all the patients. CONCLUSION: Drugs with positive inotropic action are contraindicated in patients with terminal CRF on chronic hemodialysis having CF. Regular measurements of blood flow along the arteriovenous fistula are recommended for early detection and correction of increased bypass blood flow.

Adolescent↗
PubMed1996

[Structural-metabolic features of uremic gastroenteropathy].

Concentrations of uremic toxins in the blood and jejunal juice of 72 patients with chronic renal failure (CRF) were studied as well as morphologic changes in biopsies from jejunal mucosa and submucosa, activity and location of acid and alkaline phosphatase as markers of intracellular and transmembrane transport. It was found that maximal excretion of uremic toxins in the jejunum occurs in CRF stage IIA and IIB. In terminal CRF excretion of uremic toxins delays from their concentration in the blood. This process is related with changes in enzymic processes. Histologically, all the examinees exhibited signs of chronic enteritis.

Chronic Disease↗
PubMed1991

[The factors that determine the manifestation of uremic poisoning during the development of chronic kidney failure].

To specify factors determining the intensity of uremic intoxication, 86 patients with chronic glomerulonephritis were examined without regard for exacerbation at different stages of chronic renal failure. Microcolumn gel chromatography was used to measure the content of medium-size molecules in the blood serum, urine, gastric and intestinal juice of the patients and 22 mongrel dogs before and after bilateral nephrectomy. It has been established that as the mass of acting nephrons decreases, the content of "medium-size" molecules in the blood serum and intestinal juice rises, being unchanged in gastric juice. At the same time the urinary clearance of the given group of substances declines. It is assumed that in stage I chronic renal failure, enhancement of the excretion of "medium-size" molecules in the proximal third of the small intestine is made for by hyperfiltration of intact nephrons. The appearance of the clinical symptomatology in stage II and III chronic renal failure is determined by intensification of absorption of uremic toxins by the intestine, associated with a fall of their urinary clearance. The necessity of early administration of the low-protein diet combined with enterosorbents is stressed.

Animals↗
PubMed1984

Haemoperfusion in the treatment of chronic renal failure in patients on haemodialysis.

The paper is concerned with materials characterizing physicochemical properties of haemosorbents of varying grades. Adsorption of different uraemic toxins was studied. The possibility of microembolization of internal organs and tissues with haemosorbent particles was explored in the course of prolonged treatment with the use of haemosorption. Different approaches to connecting the sorption column to the dialyzer were examined to disclose an optimal variant. The authors report the results of applying haemosorption in patients who had received haemodialysis therapy to prevent complications. The blood response to the prolonged haemosorption treatment was analyzed. It is recommended that long-term (6-7 hours) sessions of haemosorption might be performed using carbons having high sorption capacity.

Adolescent↗
PubMedDate not supplied

[Mechanism f kidney participation in maintaining osmotic and ion homeostasis in chronic renal failure].

In examination of patients with chronic renal failure (CRF) at glomerular filtration rate below 30 ml/min and blood serum ion concentration within limits of normal values hyperosmia has been found. Under the natural regimen essential differences have been revealed neither in variation limits of renal excretion of ions nor osmotically active substances in CRF patients as compared with healthy controls. Diuresis correlated with renal excretion of osmotically active substances. It is shown that a decrease in reabsorption of osmotically active substances depends on secretion and excretion of prostaglandin E2. A suggestion is made about the role of prostaglandins in regulation of renal tubular function at terminal CRF stages.

Adolescent↗
PubMedDate not supplied

[Enterosorption in experimental acute kidney failure].

The paper provides the results of 32 experiments on 22 mongrel male dogs with a view to measuring creatinine levels in the lumen of various intestinal segments before and after bilateral nephrectomy and evaluating the effects the enterosorbent brand SKN administered into isolated portions of the intestinal tube on alteration of intraluminal concentrations of creatinine, serum creatinine, and "middle-sized" molecules. Four parts of the intestine were identified: (1) proximal; (2) middle and (3) distal portions of the small intestine, and (4) the large intestine up to the anal sphincter. Two days following bilateral nephrectomy, creatinine levels were increased in the proximal, middle, distal portions of the small bowel and in the large bowel by 18, 11, 5, and 1.4 times, respectively, as compared to the baseline creatinine concentration in the intestinal parts mentioned. The administration of the enterosorbent into the different intestinal parts revealed that with its 6-hour exposure, the most potent effect (lower concentrations of creatinine and "middle-sized" molecules in serum) was observed in the proximal portions of the small bowel. This phenomenon is likely to be attributable to greater vascularization and the maximal creatinine and "middle-sized" molecule concentration in these intestinal portions. With this, it was shown that the higher baseline concentrations of serum creatinine and "middle-sized" molecules were, the more actively they absorbed on the charcoal enterosorbent brand SKN in the intestine.

Acute Kidney Injury↗
PubMedDate not supplied

[Antidiuretic hormone inhibitor in the cells of the frog bladder and its sorption].

The water flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0,049 +/- 0.017 to 1.31 +/- 0.29 mcl/cm2 min in the presence of hemosorbent SKN in the solution of the frog bladder serous membrane and from 0.054 +/- 0.015 to 0.67 +/- 0.15 mcl/cm2 min without a sorbent. The effect of polyethylene glycol 400 hyperosmotic solution on the water, cAMP and theophylline penetration was not intensified after hemosorbent use. ADH inhibitor-binding substances are present in the blood serum. The data obtained allow one to conclude that ADH enhances the water penetration, stimulating at the same time the release of the inhibitor, lowering its interaction with the receptor. Such a selfregulation is absent in the presence of hemosorbent, absorbing ADH inhibitor.

Absorption↗