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Biomedical subjects

B G Novikov

Publications and source records attributed to B G Novikov.

17 recordsLinked to original sources

[Mechanisms of adenohypophyseal development in birds].

It was established by micrurgical methods that the second step of adenohypophysis morphogenesis related to the submergence of the Rathke pouch epithelium in the proliferating mesenchyme takes place due to high adhesivity of cells of the anterior wall of adenohypophysis anlage towards diencephalon base independently submerging in the mesenchyme. Cell adhesion ensures the direct contact of both the formations on the basis of which characteristic relationships between hypothalamus and adenohypophysis arise during development.

Animals↗

[Seasonal dynamics in the function of avian pituitary gonadotropic cells].

The investigations showed that differentiation and functional activity of gonadotropocytes in ducks at different phases of a sexual cycle change in complete conformity with the quantitative changes of gonadotropic hormones in the hypophysis and peripheral blood. Intensification of the function of gonadotropocytes and an increase in the content of gonadotropins in blood and hypophysis correspond to activation of gonads. The refracteriness of gonads is accompanied by involution of gonadotropocytes and inhibition of synthesis and secretion of gonadotropins in them.

Animals↗

[Treatment of epithelial tumors of the upper urinary tracts].

The authors present the results of different operative treatments of tumors of the upper urinary tracts (UUT). A total of 116 patients with UUT tumors were examined and treated from 1990 to 2002 (age 19-80 years, mean age 61.3+/- 1.3 years; males 82, females 34). Tumors of the renal pelvis and the ureter were detected in 76 (65.5%) and 40 (34.5%) patients, respectively (8.0 and 4.3% of a total number of patients with tumors of the kidneys and UUT). 107 (92.2%) patients were operated. Nephroureterectomy and ureterectomy with resection of the urinary bladder were performed in 73 (68.2%) patients, TUR of the urinary bladder wall, ureteral ostium with pelvic part of the ureter and nephroureterectomy (including endovideosurgery) in 22 (20.6%), nephroureterocystectomy in 4 (3.7%), resection of the pelvic ureter with Boari's operation in 5 (4.7%), nephroscopy, ureteroscopy with removal of urothelial tumor in 3 (2.8%) patients. Postoperative complications (most of them infectious-inflammatory) developed in 10 (9.3%) patients. Lethality was 0.9%. Tumor recurrences occurred in 27 (25.2%) patients within 5-year follow-up. 15 (14.0%) patients were reoperated. 5-year survival reached 67.0%. Conventional and radical method of treating patients with tumors of the renal pelvis and ureter is nephroureterectomy with urinary bladder resection and its modification. In invasion of the tumor in the muscular layer of the bladder wall surgery should be extended and supplemented with cystectomy. Conservative surgical interventions are indicated in tumors of the sole kidney, bilateral process, benign or surface tumor of the urothelium.

Adult↗

[Age changes in the structure of adenohypophysical gonadotropocytes and hypothalamic arcuate nucleus neurocytes].

The results of cytochemical and electron-microscopic examinations show a similarity for age- and season-dependent changes in hormone secretion of the adenohypophysial gonadotropocytes and the arcuate nucleus function of the hypothalamus in geeze. Transition to sexual maturity and the reproductive period are connected with the intensive evacuation of secretory granules from the above-mentioned structures. The period of sexual quietness is characterized by the absence of secretory granules in the neurocytes of the arcuate nucleus and by a slow evacuation of secretion from gonadotropocytes.

Aging↗