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B G Rijkmans

Publications and source records attributed to B G Rijkmans.

9 recordsLinked to original sources
PubMed1989

Successful treatment of radiation cystitis with hyperbaric oxygen.

This report describes the results of hyperbaric oxygen therapy in 10 patients with radiation-induced cystitis. Severe macroscopic hematuria was present in all patients and was resistant to current therapy. Previously 8 patients had been treated for bladder carcinoma and 2 for prostatic carcinoma with 60 Gy radiotherapy. Hyperbaric oxygen therapy consisted of 20 sessions of 100% oxygen inhalation at 3 bar pressure for 90 min. In 6 patients the macroscopic hematuria stopped completely and it decreased in the other patients. These 4 patients had recurrent or residual bladder malignancies.

Aged↗
PubMed1984

Six-day canine kidney preservation. Hypothermic perfusion combined with isolated blood perfusion.

Successful 6-day kidney preservation was obtained with a combination of perfusion techniques. Canine kidneys were preserved by hypothermic continuous perfusion in a Gambro machine with albumin perfusate. On day 3 the hypothermic preservation was interrupted by a normothermic perfusion for 3 hr. This intermediate perfusion was performed in a heart-lung machine filled with heparinized blood from non-related dogs. The preserved kidneys were autotransplanted in subsequently nephrectomized dogs. Nine of 11 animals with such preserved kidneys survived in a healthy condition. In the control group with hypothermic perfusion only, one of 8 dogs survived after implantation. In this dog a high serum creatinine concentration was measured after implantation. Kidney function was assessed by determining glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and filtration fraction (FF) during the intermediate blood perfusion in the experimental group and at 1 hr after implantation in both groups. A low FF (less than 0.27) indicated the presence of active functioning tubules in the intermediate blood-perfused group. In this group the GFR, ERPF, and FF values returned to normal within 10 days after implantation. These results show that it is possible to prevent irreversible preservation damage by normothermic blood perfusion. Histological observation indicated that the isolated blood perfusion had a beneficial effect, especially on the tubules of the preserved kidney.

Animals↗
PubMed1983

Six-day kidney preservation in a canine model. Influence of a one-to-four-hour ex vivo perfusion interval.

Continuous hypothermic perfusion (CHP) was improved when interrupted by an interval of ex vivo perfusion. The influence of the length (1-4 hr) of this interval of ex vivo perfusion was studied in a dog model. Kidneys were subjected to CHP for 72 hr, then connected with the donor for 1, 2, 3, and 4 hr, then returned to CHP and, after a total preservation time of 144 hr, autotransplanted. Simultaneous contralateral nephrectomy was performed. Life-sustaining kidney function was obtained in all of the 6 animals in the 3-hr group and in 5 of the 6 in the 4-hr group. Shorter ex vivo perfusion intervals (1-hr and 2-hr) resulted in no survivors and 2 survivors out of 6, respectively. Creatinine levels of animals that received autotransplants of 3-hr and 4-hr ex vivo perfused kidneys returned to near normal values within 10 days after transplantation.

Animals↗
PubMed1982

Functional studies in 6 days successful preserved canine kidneys.

In 2 groups of 6 dogs each the right kidney was removed, flushed with Collins and then perfused in a Gambro preservation machine for 6 days. After this period the kidneys were reimplanted in the neck of the subsequently nephrectomized donor. The only difference in Group 2 was that halfway the 6-day hypothermic perfusion the kidneys were taken from the machine and perfused ex vivo for 3 hours by connections with the femoral vessels of the same donor dog. After implantation, only 1 dog from group 1 survived. All 6 dogs in group 2 survived. A low filtration fraction (less than 0.26) after implantation, measured 1 hour after implantation, correlated well with and predicted life sustaining kidney function. During the ex vivo perfusion in group 2, an improving proximal tubular secretion and water reabsorption was observed.

Animals↗
PubMed1980

Non-heartbeating donors, is it worthwhile?

In view of the shortage of cadaveric organ donors a retrospective study has been performed to determine the results of transplantation of non-heartbeating donor kidneys. Graft and patient survival and renal function in the 60 cases analysed in this study, showed no adverse effect of the use of non-heartbeating donor kidneys. The initial graft function was best after in situ cooling of the kidneys, using an intra-aortic double balloon catheter, followed by machine preservation. It is concluded that nephrectomy of non-heartbeating donors is worthwhile and that these donors should be included in all organ harvesting programmes.

Cadaver↗
PubMed1978

Machine perfusion versus cold storage for preservation of kidneys before transplantation.

Machine preservation was introduced into the Groningen Transplant Group in December 1972. Thirty five of the 90 kidneys transplanted in the following period of four years were preserved on a machine. The other kidneys were preserved by the so-called cold storage method. The advantages and disadvantages of both methods are outlined. Evidence is found in the literature and in this study that cold storage is sufficient for preservation-times up to 24 hours. When the preservation time exceeds this period, then machine preservation may be an advantage. Kidneys damaged by ischaemia were found to have a higher percentage of immediate function when preserved by the machine compared to those preserved by cold storage. There was no significant difference in one-year graft survival for the kidneys preserved by either method. Machine preservation helps to select between viable and non-viable kidneys from non-heartbeating donors. This is especially important in view of the lack of kidneys for transplantation. Therefore, in the opinion of the authors, it is necessary to continue with machine preservation in selected centres and to make the facilities of these centres available to every donor hospital in The Netherlands.

Animals↗